Pathological cell assembly dynamics in a striatal MSN network model
Astrid Correa,
Adam Ponzi,
Vladimir M. Calderón
et al.
Abstract:Under normal conditions the principal cells of the striatum, medium spiny neurons (MSNs), show structured cell assembly activity patterns which alternate sequentially over exceedingly long timescales of many minutes. It is important to understand this activity since it is characteristically disrupted in multiple pathologies, such as Parkinson's disease and dyskinesia, and thought to be caused by alterations in the MSN to MSN lateral inhibitory connections and in the strength and distribution of cortical excita… Show more
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