Pathological, biological and clinical characteristics, and surgical management, of elderly women with breast cancer

Molino, Annamaria; Giovannini, Monica; Amato, Alessandra; Fiorio, Elena; Mercanti, Anna; Mandarà, Marta; Caldara, A.; Micciolo, Rocco; Pavarana, M.; Cetto, Gian Luigi

doi:10.1016/j.critrevonc.2006.01.007

Cited by 65 publications

(41 citation statements)

References 39 publications

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“…The current study has supported this idea to some extent. In contrast, a number of studies indicated that older subjects are often diagnosed with high-risk tumors in comparison with younger ones (Molino et al, 2006;Botteri et al, 2010). In our series of patients, we found considerable differences in BC features among younger and older ones.…”

Section: Discussioncontrasting

confidence: 78%

“…Previous studies showed that BC has become the most 6906 on the recent changes in age distribution for primary and secondary prevention of BC (Mousavi et al, 2008;Harirchi et al, 2010). Aging is considered as one of the main risk factors for developing new BC events (Gennari et al, 2004;Molino et al, 2006;Benz, 2008). Almost, 50% of BC occurs in women ≤65 years and more than 30% in women ≤70 years in developed nations (Yancik et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Trends in Epidemiology, Clinical and Histopathological Characteristics of Breast Cancer in Iran: Results of a 17 Year Study

Afsharfard

Mozaffar²,

Orang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Lower stages (0 and I) were more frequent among the oldest patients while nearly 50% of patients aged ≤40 had tumor stage III. We also observed a significant decreasing trend in the mean LN count (p<0.05) and blood vessel invasion (p=0.023) from younger to older age groups. Conclusions: More aggressive disease for younger age groups, earlier peak incidence age and high rate of advanced BC at the time of diagnosis among Iranian women, were the main findings of this study.

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Section: Discussioncontrasting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Trends in Epidemiology, Clinical and Histopathological Characteristics of Breast Cancer in Iran: Results of a 17 Year Study

Afsharfard

Mozaffar²,

Orang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…According to our study, histological types of breast cancer were as follows: 79% IDC, 7% ILC, 10% IMC and 4% other rare forms. Positive expression of ER and PR was higher in ILC's than in IDC cases (25)(26)(27)(28). It is thought that hormone replacement therapy results in increase of tumors of especially ILC histology due to this increase in expression of hormone receptors (29).…”

Section: Discussionmentioning

confidence: 97%

“…Moreover, the fact that 48% of breast cancer cases detected in this prospective clinical study were in the 40-49 years age group, the KSDB (Cancer Control Department) adjusted the existing age limit for screening from 50-69 years to 40-69 years of age as of 2012. "Invasive ductal carcinoma" is the most common histological type of breast cancer, constituting 49 to 75% of invasive breast cancer according to various studies (25)(26)(27)(28). According to our study, histological types of breast cancer were as follows: 79% IDC, 7% ILC, 10% IMC and 4% other rare forms.…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer in Turkey: Clinical and Histopathological Characteristics (Analysis of 13.240 Patients)

Özmen

2014

J Breasth Health

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Objective: Breast cancer is the most common type of cancer and the leading cause of cancer related deaths in women in Turkey, as elsewhere around the world. However, detailed and systematic demographics, data on clinical and pathological characteristics, and treatment were largely unavailable in Turkey until now. This paper is intended to provide an analysis of clinical and pathological data on women registered in the National Breast Cancer Database (Ulusal Meme Kanseri Veri Tabanı Results: A total of 13,240 patients with breast cancer since April 07, 1992 were included in the study, and 99% of them were female. Female breast cancer patients whose requisite parameters had been completely entered in the database were included in the analysis. The mean age was 51.6 years (±12.6; range 12-97), 17% of them were younger than 40 years of age, and 45% were premenopausal. According to an analysis of age groups at diagnosis, the frequency of cancer peaked at the 45 -49 age group with 16.7%, declining to 7.6% in the 65-69 age group, and then rose again. Most of the patients (78.7%) had invasive ductal, 7.8% were invasive lobular cancers, 9.8% were invasive mixed cancers (invasive ductal + invasive lobular), and 4% were other histological types (e.g. inflammatory, intracystic papillary, mucinous, etc.), respectively. Half of them (50%) had grade III histology. According to an analysis of pathological stages of all breast cancers (stage 0 -IV), 5% were stage 0, 27% were stage I, 44% were stage II, 21% were stage III, and 3% were stage IV breast cancer, respectively. The mean tumor diameter was 2.5 cm (±1.6; range 0.1-20 cm). The rates of lymphatic stages were pN0 50%, pN1 28%, pN2 15%, and pN3 7%, respectively. ER, PR, and HER-2 receptors were positive in 70%, 59%, and 23% of patients. A subtype analysis of tumors showed that 62% were type luminal A. This was followed by subtypes luminal B (15%), triple negative (15%), and HER-2 positive (8.5%). Conclusion:As a conclusion patients with breast cancer in our breast cancer registry program were younger, and had more advanced disease, and worse prognostic factors than patients in developed countries.

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“…Treatment-related morbidity plays a significant role in the application of curative treatment in elderly patients; older patients are more likely to prefer an improvement in their current quality of life rather than a potential increase in survival (Yellen et al, 1994). As a consequence, elderly patients generally receive less aggressive and intensive treatment (Vrana et al, 2013;Wildiers, 2008;Thapa et al, 2013;Molino et al, 2006;Phua et al, 2010). However, more than half of elderly BC patients are undertreated, which significantly reduces their cancer-related survival (Wyld and Reed, 2007;Bouchardy et al, 2003;Bland et al, 1999;Yood et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Distinct Postsurgical Management in Young and Elderly Breast Cancer Patients Results in Equal Survival Rates

Oran

Yankol²,

Soybir³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Although breast cancer (BC) is one of the most common malignant diseases in women, the majority of the studies describing the characteristics of BC in elderly patients have been limited to survival assessments or tumor features, without using younger BC patients as a reference group. The aim of our study was to describe and compare tumor characteristics and management patterns in elderly versus younger breast cancer patients in Turkey. Materials and Methods: We retrospectively analyzed 152 patients with invasive breast cancer who underwent surgery in our institution between 2002 and 2012. Patients were divided into 2 groups according to age at the time of diagnosis. Results: There were 62 patients in the elderly group (≥65 years) and 90 patients in the younger group (<65 years). Compared to the younger group, tumors in the elderly group were more likely to be larger (p=0.018), of lower grade (p=0.005), and hormone receptor-positive (p>0.001). There were no significant differences regarding histology, localization, lymph node involvement, or types of surgical procedures between the 2 groups. Comorbidities were more common in elderly patients (p<0.001). In addition, elderly patients were more likely to receive hormonal therapy (p<0.001) and less likely to receive radiotherapy (p=0.08) and chemotherapy (p=0.003). There was no difference in survival and locoregional recurrence rates between the groups. Conclusions: The results of this study demonstrate that breast cancer in elderly patients has more favorable tumor features, warranting less aggressive treatment regimens after surgery.

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Pathological, biological and clinical characteristics, and surgical management, of elderly women with breast cancer

Cited by 65 publications

References 39 publications

Trends in Epidemiology, Clinical and Histopathological Characteristics of Breast Cancer in Iran: Results of a 17 Year Study

Trends in Epidemiology, Clinical and Histopathological Characteristics of Breast Cancer in Iran: Results of a 17 Year Study

Breast Cancer in Turkey: Clinical and Histopathological Characteristics (Analysis of 13.240 Patients)

Distinct Postsurgical Management in Young and Elderly Breast Cancer Patients Results in Equal Survival Rates

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