Pathological attenuation of the right prefrontal cortex activity predicts speech and limb motor timing disorder in Parkinson’s disease

Behroozmand, Roozbeh; Johari, Karim

doi:10.1016/j.bbr.2019.111939

Cited by 8 publications

(5 citation statements)

References 46 publications

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“…PD patients, in comparison with healthy controls, exhibited poorer control over the duration of speech events, 27 higher oral motor coordination variability, longer speech initiation times, more errors on a speaking task, lower scores on a speech comprehension task, 28 and longer motor reaction times. [29][30][31] Our study provides deeper insight into these results by demonstrating that the group of PD patients with speech disorders has longer reaction times than those without speech disorders.…”

Section: Reaction Times-comparison Within Subpopulations Of Pd Patientsmentioning

confidence: 67%

Impaired Timing of Speech-Related Neurons in the Subthalamic Nucleus of Parkinson Disease Patients Suffering Speech Disorders

Tankus¹,

Lustig²,

Fried³

et al. 2021

Neurosurg.

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BACKGROUND Our previous study found degradation to subthalamic neuronal encoding of speech features in Parkinson disease (PD) patients suffering from speech disorders. OBJECTIVE To find how timing of speech-related neuronal firing changes in PD patients with speech disorders compared to PD patients without speech disorders. METHODS During the implantation of deep brain stimulator (DBS), we recorded the activity of single neurons in the subthalamic nucleus (STN) of 18 neurosurgical patients with PD while they articulated, listened to, or imagined articulation of 5 vowel sounds, each following a beep. We compared subthalamic activity of PD patients with (n = 10) vs without speech disorders. RESULTS In this comparison, patients with speech disorders had longer reaction times and shorter lengths of articulation. Their speech-related neuronal activity preceding speech onset (planning) was delayed relative to the beep, but the time between this activity and the emission of speech sound was similar. Notwithstanding, speech-related neuronal activity following the onset of speech (feedback) was delayed when computed relative to the onset. Only in these patients was the time lag of planning neurons significantly correlated with the reaction time. Neuronal activity in patients with speech disorders was delayed during imagined articulation of vowel sounds but earlier during speech perception. CONCLUSION Our findings indicate that longer reaction times in patients with speech disorders are due to STN or earlier activity of the speech control network. This is a first step in locating the source(s) of PD delays within this network and is therefore of utmost importance for future treatment of speech disorders.

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Section: Reaction Times-comparison Within Subpopulations Of Pd Patientsmentioning

confidence: 67%

Impaired Timing of Speech-Related Neurons in the Subthalamic Nucleus of Parkinson Disease Patients Suffering Speech Disorders

Tankus¹,

Lustig²,

Fried³

et al. 2021

Neurosurg.

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“…The reason why we only found significant differences in the imaging parameters on the right side is still not well explained. A previous study showed that pathological attenuation of neural activities within the right-lateralized cortical network is a neurophysiological biomarker of speech and limb movement timing deficits in PD ( 41 ). There is another study which found that memory-impaired PD patients demonstrated a more significant reduction in D2 receptor binding in the right medial temporal lobe compared to healthy controls and PD patients with no MCI ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

The mechanism of impaired delayed recall verbal memory function in Parkinson's disease with orthostatic hypotension: a multiple imaging study

et al. 2023

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IntroductionOrthostatic hypotension (OH) frequently accompanies autonomic dysfunction and is an important risk factor for cognitive impairment in Parkinson's disease (PD). However, the association between different cognitive functions and OH in PD patients is not yet fully understood.MethodsThis study aimed to evaluate the scores of different cognitive domains and multiple parameters using different imaging techniques on PD patients with or without OH. A total number of 31 PD patients with OH (n = 20) and without OH (n = 11) were recruited from the Department of Neurology, Beijing Xuanwu Hospital for this study. All patients underwent beat-to-beat non-invasive blood pressure recordings and an active standing test to evaluate neurogenic OH and a global neuropsychological test to assess cognitive function. All patients underwent dynamic cerebral autoregulation (dCA) measurement, brain magnetic resonance imaging (MRI), and brain 18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT).ResultsThe results showed that OH patients had poor delayed recall verbal memory when compared with the PD patients without OH (1.75 ± 1.59 vs. 3.10 ± 1.73, p = 0.042). The dCA test indicated a significant difference in the right very low-frequency (VLF) gain between two groups (1.27 ± 0.17 vs. 1.10 ± 0.26, p = 0.045) and the brain 18F-FDG PET/CT indicated a significant difference in the SUV (right medial temporal lobe) to SUV (occipital lobe) ratio (0.60 ± 0.08 vs. 0.67 ± 0.11, p = 0.049). Meanwhile, these two imaging parameters were negatively correlated (p < 0.001). Furthermore, the score of a delayed recall verbal memory in the OH group was positively correlated with the right medial temporal lobe to occipital lobe ratio (p < 0.001) and was negatively correlated with the right VLF gain (p = 0.023).DiscussionPD with OH patients had poor delayed recall memory, which might have been caused by the decreased metabolic dysfunction of specific medial temporal lobe due to the impaired dCA ability.

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“…Moreover, these two modalities demonstrate similar spatiotemporal patterns of pre‐movement EEG activity (Johari & Behroozmand, 2017a, 2020). In neurological conditions such as PD, both speech and limb movement are often concurrently impaired—albeit to varying degrees—suggesting that common neural substrates support speech and limb functions (Behroozmand & Johari, 2019; Rusz et al., 2017). Understanding inhibitory mechanisms of speech versus limb movement is particularly important for informing studies that aim to improve speech and limb movement deficits in neurological conditions.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, these two modalities demonstrate similar spatiotemporal patterns of pre-movement EEG activity (Johari & Behroozmand, 2017a. In neurological conditions such as PD, both speech and limb movement are often concurrently impaired-albeit to varying degrees-suggesting that common neural substrates support speech and limb functions (Behroozmand & Johari, 2019;Rusz et al, 2017).…”

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confidence: 99%

Theta oscillations within right dorsolateral prefrontal cortex contribute differently to speech versus limb inhibition

Johari,

Berger

2024

J of Neuroscience Research

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Evidence suggests that speech and limb movement inhibition are subserved by common neural mechanisms, particularly within the right prefrontal cortex. In a recent study, we found that cathodal stimulation of right dorsolateral prefrontal cortex (rDLPFC) differentially modulated P3 event‐related potentials for speech versus limb inhibition. In the present study, we further analyzed these data to examine the effects of cathodal high‐definition transcranial direct current stimulation (HD‐tDCS) over rDLPFC on frontal theta ‐ an oscillatory marker of cognitive control ‐ in response to speech and limb inhibition, during a Go/No‐Go task in 21 neurotypical adults. Electroencephalography data demonstrated that both speech and limb No‐Go elicited prominent theta activity over right prefrontal electrodes, with stronger activity for speech compared to limb. Moreover, we found that cathodal stimulation significantly increased theta power over right prefrontal electrodes for speech versus limb No‐Go. Source analysis revealed that cathodal, but not sham, stimulation increased theta activity within rDLPFC and bilateral premotor cortex for speech No‐Go compared to limb movement inhibition. These findings complement our previous report and suggest (1) right prefrontal theta activity is an amodal oscillatory mechanism supporting speech and limb inhibition, (2) larger theta activity in prefrontal electrodes for speech versus limb following cathodal stimulation may reflect allocation of additional neural resources for a more complex motor task, such as speech compared to limb movement. These findings have translational implications for conditions such as Parkinson's disease, wherein both speech and limb movement are impaired.

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Pathological attenuation of the right prefrontal cortex activity predicts speech and limb motor timing disorder in Parkinson’s disease

Cited by 8 publications

References 46 publications

Impaired Timing of Speech-Related Neurons in the Subthalamic Nucleus of Parkinson Disease Patients Suffering Speech Disorders

Impaired Timing of Speech-Related Neurons in the Subthalamic Nucleus of Parkinson Disease Patients Suffering Speech Disorders

The mechanism of impaired delayed recall verbal memory function in Parkinson's disease with orthostatic hypotension: a multiple imaging study

Theta oscillations within right dorsolateral prefrontal cortex contribute differently to speech versus limb inhibition

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