Pathological and Immunopathological Studies on Naturally Infected Cases of Porcine Circovirus-2 in Kerala

Abstract

Porcine circovirus-2 (PCV2) is one such emerging viral pathogen of concern as it is involved in the

Myeloid to Erythroid (M: E) ratio in the evaluation of bone marrow cytology of Porcine Circovirus type 2 affected pigs

“…A numerical decrease of erythroid cells and mild increase of myeloid cells were noticed on bone marrow cytology. The M: E ratio in PCV-2 positive animals was 1.2: 1 whereas that in apparently healthy pigs was 0.9:1. previous reports of Keerthana et al (2017) and Sairam et al (2019). In the present study, cases suggestive by gross and histopathological lesions were confirmed by PCR.…”

“…The pooled tissue samples from mesenteric lymph nodes, tonsils, lungs and bone marrow (Keerthana et al, 2017) were collected and investigated. Lymphoid organs and nonlymphoid organs were collected in 10% neutral buffered formalin for histopathological evaluation (Suvarna et al, 2019).…”

“…Profound alteration of the immune system is characteristic of for PCV-2 infections. Microscopically, there was lymphoid depletion in T and B cell areas and histiocytic infiltration in lymphoid organs and presence of multinucleated giant cells (Keerthana et al, 2017;Sairam et al, 2019). These changes in the lymphoid organs are well documented.…”