Pathological and epidemiological investigations into listerial encephalitis in sheep

Kumar, Hardeep; Singh, Balwant; Bal, Mandeep Singh; Kaur, Kamalpreet; Singh, Randhir; Sidhu, Pritam K.; Sandhu, Karamjeet S.

doi:10.1016/j.smallrumres.2006.05.010

Cited by 22 publications

(28 citation statements)

References 12 publications

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“…Cattle appear to be less susceptible to the infection than small ruminants [4]. Occasionally, listeriosis may occur as an outbreak, particularly in sheep and goats [101, 104, 111, 113, 125, 127] (and own observations). The mortality rate is high despite antibiotic treatment [102].…”

Section: Listeriosis In Ruminantsmentioning

confidence: 99%

Rhombencephalitis Caused byListeria monocytogenesin Humans and Ruminants: A Zoonosis on the Rise?

Oevermann

Zurbriggen

Vandevelde

2010

Interdisciplinary Perspectives on Infectious Diseases

125

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Listeriosis is an emerging zoonotic infection of humans and ruminants worldwide caused by Listeria monocytogenes (LM). In both host species, CNS disease accounts for the high mortality associated with listeriosis and includes rhombencephalitis, whose neuropathology is strikingly similar in humans and ruminants. This review discusses the current knowledge about listeric encephalitis, and involved host and bacterial factors. There is an urgent need to study the molecular mechanisms of neuropathogenesis, which are poorly understood. Such studies will provide a basis for the development of new therapeutic strategies that aim to prevent LM from invading the brain and spread within the CNS.

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Section: Listeriosis In Ruminantsmentioning

confidence: 99%

Rhombencephalitis Caused byListeria monocytogenesin Humans and Ruminants: A Zoonosis on the Rise?

Oevermann

Zurbriggen

Vandevelde

2010

Interdisciplinary Perspectives on Infectious Diseases

125

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“…There are many pathogenic spp of Listeria known to be excreted in faeces and vaginal secretions which can act as a source of infection in the environment. The listeric infection in animals is mainly transmitted by consumption of spoiled silage, aborted materials and vaginal secretions in which these bacteria multiply readily, resulting in outbreaks, especially in the sheep (Low and Donachie, 1997;Kumar et al, 2007). In our study, the pathogenic and non-pathogenic spp.…”

Section: Discussionmentioning

confidence: 81%

“…Of these, L. monocytogenes is a well-known cause of abortion, encephalitis and septicaemia in animals and human beings (Rocourt and Seeliger, 1985;McLauchlin, 1987;Kumar et al, 2007). The other pathogenic spp, L. ivanovii was isolated from cases of abortion, still birth and neonatal septicemia in sheep and cattle ( Jose et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

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Isolation and Characterization of Listeria spp. from Organized and Migratory Sheep Flocks in India

Keelara¹

2015

Adv. Anim. Vet. Sci.

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| In the present investigation, a total of 880 clinical samples comprising blood (n=215), vaginal swabs (n=220), fecal swabs (n=220), placenta (n=10) and sera (n=215) from ewes with abortion or history of abortion as well as from apparently healthy ewes of organized and migratory flocks were collected for screening listeric infection by isolation, serological and molecular diagnostic methods. 23 different isolates were recovered which comprised of 15 L. monocytogenes, 2 L. ivanovii and 6 other listeriae. Among these, four haemolytic isolates (L. ivanovii-2 and L. monocytogenes-2) were found pathogenic based on hemolysis on sheep blood agar, CAMP test, PI-PLC activity, virulence-associated genes (prfA, plcA, actA, hlyA and iap) as well as by in vivo pathogenicity tests namely, chick embryo and mice inoculation tests. Indirect plate ELISA revealed 41.96% seropositivity for antibodies against listeriolysin O in ewes with abortion or history of abortion and 26.21% in apparently healthy ewes, which after adsorption of sera with Streptolysin O (SLO) reduced to 18.75% and 9.70% in respective groups. On over all basis, out of 215 sheep sera, 74 (34.42%) sera showed positivity for ALLO, which was reduced to 31(14.42%) following adsorption with SLO, indicating the need for sera adsorption for removing the cross-reactivity. The study had significant implications in understanding the epidemiology of listeric infection in migratory flocks.

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“…Antibodies against LLO have also been detected in apparently healthy goats (Barbuddhe et al, 2000b). The outbreaks of listerial encephalitis were reported in the migratory flocks of sheep in Punjab (Kumar et al, 2007). Vishwanathan and Uppal (1981) isolated L. grayi from the brain of a sheep that died after exhibiting signs of the cerebral form of listeriosis.…”

Section: Resultsmentioning

confidence: 99%

Isolation and Characterization of Listeria Monocytogenes from Goat Brain

Shivasharanappa¹

2014

Adv. Anim. Vet. Sci.

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Caprine listeriosis caused by Listeria monocytogenes is a disease of zoonotic importance. Listeriosis involves central nervous system of goat which is manifested in various clinical signs. A total of 69 brain samples from different breeds of goat collected from the postmortem cases and slaughter house were examined for the presence of pathogenic Listeria. Twenty one brain samples were found positive for listeria by cultural, biochemical, phenotypic and genotypic characteristics. Among these, nine isolates were characterized as Listeria monocytogenes. The isolates were positive for the hly and actA virulence genes by PCR assay. All the isolates belonged to 4b, 4d and 4e serovar group using multiplex PCR based serotyping. No characteristic pathological lesions of listeriosis have been found in the brain. The isolation of L. monocytogenes is important with regard to food safety and public health, representing a possible link between the animals, environment and human infection. All copyrights reserved to Nexus® academic publishers

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Pathological and epidemiological investigations into listerial encephalitis in sheep

Cited by 22 publications

References 12 publications

Rhombencephalitis Caused byListeria monocytogenesin Humans and Ruminants: A Zoonosis on the Rise?

Rhombencephalitis Caused byListeria monocytogenesin Humans and Ruminants: A Zoonosis on the Rise?

Isolation and Characterization of Listeria spp. from Organized and Migratory Sheep Flocks in India

Isolation and Characterization of Listeria Monocytogenes from Goat Brain

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