Insecticides are chemical compounds that are extensively used for pest management in agriculture, urban and household environments as well as in the medicine to control different diseases such as typhus and malaria amongst others. The purpose of the current study was to investigate the toxicity effects of the compound insecticide (Acetamiprid with Thiamethioxam) on the development of Broiler chicken embryo Ross 308. Two hundred and fifty fertile eggs were divided into six groups as follows: control groups one was injected with distilled water and the other four groups were injected into the yolk sac with 100µl/egg from Acetamiprid with Thiamethioxam at concentrations (360, 540, 900 and 1800ppm). The morphological features were studied on the days 10 and 21 of incubation. The results showed that the four concentrations caused reduction in the weight of treated embryos and significant increase in the mortality. In addition, there were clear abnormalities in both ages (10 and 21) including over growth in the brain, twisted cleft beak, wry neck, eye deformation, ectopia visceral, delayed retraction of yolk sac, abnormal limbs, and broken legs. Microscopically, the liver tissue showed different changes at both incubation periods (10th day and 21st day) including necrosis and degenerative changes of hepatocytes with congestion of central vein and sinusoids with mononuclated inflammatory cells infiltration. To conclude, the current study revealed that Acetamiprid with Thiamethioxam caused significant morphological and histological changes in chicken Ross 308.