Abstract:Batch safety tests (BSTs) of veterinary vaccines are conducted using small laboratory
animals to assure the safety of vaccines according to several criteria, including clinical
signs and change in body weight. Although the latter is used as an evaluation index in
BSTs, there have been no reports on the internal changes that affect body weight during
the test period. Therefore, we analyzed BST via pathological examination of the tested
animals. Here, BSTs were performed for 176 batches using mice and 126 batche… Show more
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