Pathologic Triggers Related to LUTS and BPH

Mirone, Vincenzo; Rocca, Roberto La; Franco, Marco; Venturino, Luca

doi:10.1016/b978-0-12-811397-4.00002-0

Cited by 4 publications

(8 citation statements)

References 77 publications

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“…5-Alpha reductase converts androgens to estrogen and dihydrotestosterone (DTH). Estrogen has a key role in the growth and increase in prostate cells through oxidative function and after being combined with DTH, it can cause an additional effect on BPH [8]. Finasteride treatment reduces 5-alpha reductase function and decreases DTH blood level and, thereby, reduces oxidative stress and preserves the body's antioxidants.…”

Section: Discussionmentioning

confidence: 99%

“…The aromatase enzyme and 5-alpha reductase activity increase with age [6]. This enzyme is responsible for the conversion of androgens to estrogen and dihydrotestosterone [7,8]. As a result, testosterone levels decrease, but this hormone's metabolites (estrogen and dihydrotestosterone) increase.…”

Section: Introductionmentioning

confidence: 99%

“…As a result, testosterone levels decrease, but this hormone's metabolites (estrogen and dihydrotestosterone) increase. Estrogen plays an important role in the growth of a cell and in increasing prostate cells [8]. Dihydrotestosterone works locally by binding to androgen receptors in the cell nuclei, and signals the transcription of growth factors that are mitogenic to the epithelial and stromal cells [9].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Juniperus communis L. seed extract on benign prostatic hyperplasia induced in male Wistar rats

Akbari

Azadbakht

Megha³

et al. 2021

Afr J Urol

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Background Benign prostatic hyperplasia (BPH) is a common disease which causes various health problems for elderly men such as urinary retention, recurring urinary tract infection and bladder stones. The aim of this study is to evaluate the therapeutic effects of Juniperus communis L. seed extract (JCS) on BPH in male Wistar rats. Methods To this end, 30 rats were divided into 5 groups (N = 6): group 1 (vehicle), group 2 (disease control), group 3 (standard medicine; 10 mg/kg finasteride), and groups 4 and 5 were treated with 300 mg/kg and 600 mg/kg of the hydroalcoholic JCS seed extract, respectively. Groups 2, 3, 4 and 5 received testosterone enanthate to induce prostatic hyperplasia. At the end of experimental period (28 days), prostate glands were cut off under anesthesia. Histopathological examination was done and biochemical parameters such as Malondialdehyde, Glutathione and protein carbonyl were also measured. Their body weights were also observed during the study. At the end of the experiment, prostate weights and prostate specific antigen (PSA) levels were measured. Prostate index, inhibition prostate weight and inhibition prostate index were also calculated. Results Both histopathological examination and biochemical parameter results showed significant improvements in rats treated with finasteride and 600 mg/kg JCS extract (p < 0.01). In addition, PSA levels showed significant decrease in comparison with the disease group. But acute toxicity test indicated that using JCS extract resulted in an increase in liver enzymes (ALP, LDH, SGOT, SGPT). As a result, the extract should be used with caution. Conclusions Oral administration of JCS extract is effective on preventing testosterone-induced benign prostatic hyperplasia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Juniperus communis L. seed extract on benign prostatic hyperplasia induced in male Wistar rats

Akbari

Azadbakht

Megha³

et al. 2021

Afr J Urol

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“…The activation of these enzymes increases with age. Due to the decrease in testosterone levels and the increase in its metabolites and the role of estrogen on prostate cell proliferation, the risk of getting BPH increases [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Therapeutic Effect of the Traditional Herbal Medicine Atrifil and Oshagh Gum on Testosterone-Induced Benign Prostatic Hyperplasia in Wistar Rats

Akbari

Azadbakht

Gaurav

et al. 2022

Advances in Urology

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Benign prostatic hyperplasia (BPH) is a common disease that affects elderly men with various complications. This study evaluates the effects of an Iranian traditional herbal medicine “Atrifil and Oshagh gum” on BPH in male Wistar rats. Atrifil is a combination of three medicinal plants: Emblica officinalis Gaertn, Terminalia chebula Retz, and Terminalia bellerica Retz” extracts, and Oshagh gum is Dorema ammoniacum D. Dono gum. In this study, 30 male Wistar rats were divided into five groups: normal control, disease, finasteride, and extract with 300 and 600 mg/kg groups. The extract is a combination of hydroalcoholic Atrifil extract and Oshagh gum. All groups received intramuscular testosterone enanthate to induce BPH except the normal control group. On the twenty-eighth day, prostate glands were separated. Histopathological changes were observed. Furthermore, the prostate-specific antigen (PSA) and prostate weights were measured. The binding propensities of finasteride, equol, and flavonoids present in this extract such as quercetin, rutin, and kaempferol for 5α-reductase, estrogen receptor alpha and beta, and estrogen-related receptor gamma were assessed using in silico docking approach. Histopathological evaluation, biochemical parameter, and PSA level results indicated significant inhibition of accruing and progression of BPH in groups treated with 600 mg/kg extract ( p < 0.01 ). Furthermore, molecular docking showed that rutin had a high affinity to bind the receptors 5α-reductase, estrogen receptor beta, and estrogen-related receptor gamma even more than finasteride, and on average, quercetin had a higher affinity to all these receptors. In the end, it can be concluded that Atrifil and Oshagh gum is effective in preventing BPH.

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“…The major symptom observed in ageing males is the lower urinary tract symptoms (LUTS) which is a sign of BPH. The reason behind BPH histological condition is obstruction caused in bladder outlet which further obstructs prostate (Mirone et al 2018 ).…”

Section: Introductionmentioning

confidence: 99%

In-silico and in-vivo evaluation of sesamol and its derivatives for benign prostatic hypertrophy

Shah

Nandakumar

et al. 2021

3 Biotech

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Pharmacological treatment for BPH includes 5-α reductase inhibitors as Finasteride and Dutasteride as a monotherapy or in combination with antimuscarinic drugs, alpha-blockers, 5-phosphodiesterase inhibitor drugs. Androgen receptor inhibitors revealed several adverse events as decreased libido, erectile dysfunction, ejaculatory dysfunction, and gynecomastia. Hence, the emergence of complementary and alternative medications having safety profile—preferably, edible natural products—would be highly desirable. In-silico studies based on Maestro Molecular Modelling platform (version 10.5) by Schrӧdinger, LLC was used to identify the lead molecules. The in-vivo activity studied on rats gave the positive results. The findings based on experiments as antioxidant parameters showed the potential to quench the free radicals. The significant results were also seen in prostatic index and histopathological studies supported the above findings. Based on these data, sesamol and derivative have proven efficacy in protecting against testosterone induced BPH.

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Pathologic Triggers Related to LUTS and BPH

Cited by 4 publications

References 77 publications

Evaluation of Juniperus communis L. seed extract on benign prostatic hyperplasia induced in male Wistar rats

Evaluation of Juniperus communis L. seed extract on benign prostatic hyperplasia induced in male Wistar rats

Evaluation of the Therapeutic Effect of the Traditional Herbal Medicine Atrifil and Oshagh Gum on Testosterone-Induced Benign Prostatic Hyperplasia in Wistar Rats

In-silico and in-vivo evaluation of sesamol and its derivatives for benign prostatic hypertrophy

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