Pathologic role of nitrergic neurotransmission in mood disorders

Ghasemi, Mehdi; Claunch, Joshua D.; Niu, Kathy

doi:10.1016/j.pneurobio.2018.06.002

Cited by 28 publications

(14 citation statements)

References 557 publications

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“…It is unclear whether the above psychiatric symptoms are a direct consequence of the CNS viral infection (i.e. viral meningoencephalitis), cerebrovascular accidents, hypoxia, and the immunological and inflammatory responses, which may play important roles in major depressive disorder ( Ghasemi et al, 2019 ; Wohleb et al, 2016 ) and psychosis ( Ferrando et al, 2020 ), or whether they are related to increased psychosocial stress of this severe and potentially fatal disease and difficulties accessing to health care related to the pandemic infection ( Zhou and Yao, 2020 ). This has been posing increased challenges in the treatment of infected patients, especially those in the ICU, requiring accurate multidisciplinary approaches and early interventions to decrease overall morbidity and mortality ( Ojeahere et al, 2020 ).…”

Section: Psychiatric Manifestationsmentioning

confidence: 99%

SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation

Keyhanian

Umeton

Mohit

et al. 2021

Journal of Neuroimmunology

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117

146

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Since the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a growing body of evidence indicates that besides common COVID-19 symptoms, patients may develop various neurological manifestations affecting both the central and peripheral nervous systems as well as skeletal muscles. These manifestations can occur prior, during and even after the onset of COVID-19 general symptoms. In this Review, we discuss the possible neuroimmunological mechanisms underlying the nervous system and skeletal muscle involvement, and viral triggered neuroimmunological conditions associated with SARS-CoV-2, as well as therapeutic approaches that have been considered for these specific complications worldwide.

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Section: Psychiatric Manifestationsmentioning

confidence: 99%

SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation

Keyhanian

Umeton

Mohit

et al. 2021

Journal of Neuroimmunology

Self Cite

117

146

View full text Add to dashboard Cite

show abstract

“…In fact, the polymorphism of the OXT receptor gene associated with high sensitivity (rs53576) is more frequent in highs than in the general population (Bryant et al, 2013). d. brain nitric oxide (NO) promotes the release of brain dopamine and noradrenaline (Ghasemi et al, 2019), which are involved in pain control. According to post-occlusion flow mediated dilation (FMD), the endothelial NO release at peripheral level is reduced in lows and in the general population, but not in highs (Jambrik et al, 2004a,b;Jambrik et al, 2005).…”

Section: Neurotransmittersmentioning

confidence: 99%

Individual Traits and Pain Treatment: The Case of Hypnotizability

Santarcangelo

Carli

2021

Front. Neurosci.

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“…NO is synthesized by NOS, which has three isoforms, namely, nNOS, iNOS, and eNOS, and all three NOS isoforms exist in the CNS and affect cell signaling in brain (29). Evidence has shown that deficits in NOS activity are associated with the neurobiology of MDD (30,31). Especially for nNOS, studies have shown that dysfunction of nNOS in the paraventricular hypothalamic nucleus, locus coeruleus, mPFC, and hippocampus, is related to MDD (29,32,33).…”

Section: Discussionmentioning

confidence: 99%

Repeated Nitrous Oxide Exposure Exerts Antidepressant-Like Effects Through Neuronal Nitric Oxide Synthase Activation in the Medial Prefrontal Cortex

Liu

et al. 2020

Front. Psychiatry

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Clinical studies have demonstrated that exposure to the inhalational general anesthetic nitrous oxide (N 2 O) produces antidepressant effects in depressed patients. However, the mechanisms underlying the antidepressant effects of N 2 O remain largely unknown. Neuronal nitric oxide synthase (nNOS)-mediated nitric oxide (NO) synthesis is essential for brain function and underlies the molecular mechanisms of many neuromodulators. We hypothesized that activation of the nNOS/NO pathway in the medial prefrontal cortex (mPFC) might mediate the antidepressant effects of N 2 O. In this study, we revealed that repeated N 2 O exposure produced antidepressant-like responses in mice. Our mechanistic exploration showed that repeated N 2 O exposure increased burst firing activity and that the expression levels of BDNF with nNOS activation were dependent in the mPFC. In particular, the antidepressant-like effects of N 2 O were also antagonized by local nNOS inhibition in the mPFC. In summary, our results indicated that N 2 O exposure enhances BDNF expression levels and burst firing rates in an nNOS activation dependent manner, which might underlie the pharmacological mechanism of the antidepressant-like effects of N 2 O exposure. The present study appears to provide further mechanistic evidence supporting the antidepressant effects of N 2 O.

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Pathologic role of nitrergic neurotransmission in mood disorders

Cited by 28 publications

References 557 publications

SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation

SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation

Individual Traits and Pain Treatment: The Case of Hypnotizability

Repeated Nitrous Oxide Exposure Exerts Antidepressant-Like Effects Through Neuronal Nitric Oxide Synthase Activation in the Medial Prefrontal Cortex

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