Pathologic Quiz Case: A 70-Year-Old Woman With Postmenopausal Bleeding

Moid, Farah; Berezowski, Katherine

doi:10.5858/2004-128-e157-pqcayw

Cited by 8 publications

(7 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on our and previous reports, CC-EIC appears analogous to S-EIC, as it recapitulates the morphologic and immunophenotypical features of its invasive counterpart [ 7 – 9 , 13 ]. On this account, CC-EIC may be defined by the presence of atypical cuboidal, polygonal or hobnail cells with clear-to-eosinophilic cytoplasm, which replace the epithelial lining of endometrial surface and glands with no evidence of invasive disease.…”

Section: Discussionsupporting

confidence: 61%

“…Both EIC and EmGD have also been proposed as steps of CC-EC carcinogenesis under the name of clear cell type EIC and EmGD (“CC-EIC and CC-EmGD”); however, very few data have been published about these entities [ 7 – 9 , 13 ], and the current WHO classification does not list any putative precursor of CC-EC [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…To date, only one series of putative precursors of CC-EC has been published [ 6 ]. In addition, very few cases of CC-EC limited to the endometrial epithelium have been described [ 7 – 9 ]; such cases have been referred to as “endometrial intraepithelial carcinoma (EIC), clear cell-type” or “clear cell EIC” (CC-EIC).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clear cell endometrial carcinoma precursors: presentation of two cases and diagnostic issues

et al. 2021

View full text Add to dashboard Cite

Background The precursors of clear cell endometrial carcinoma (CC-EC) are still undefined. Here, we deal with the diagnostic issues related to CC-EC precursors by presenting a morphological, immunophenotypical and molecular study of two representative cases and discussing the relevant literature. Case presentation Our and previous cases suggest that clear cell endometrial intraepithelial carcinoma (CC-EIC) is a real entity, which may be distinguished from metaplastic/reactive changes and from its serous counterpart. CC-EIC appears associated with atrophic polyps and may be diagnosed based on morphological and immunophenotypical features of CC-EC in the absence of invasive disease. We described a p53-mutant putative precursor characterized by high-grade nuclei in the absence of other distinctive features. Two putative low-grade precursors resembled atypical tubal metaplasia and endometrial intraepithelial neoplasia, although immunohistochemistry could not support their relationship with CC-EC. Conclusions In conclusion, pathologists should be aware of the existence of CC-EIC, since its correct diagnosis may be crucial for a correct patient management. Although several putative earlier precursors have been described, they does not show univocal features that allow their recognition in the common practice. Further studies are necessary in this field.

show abstract

Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clear cell endometrial carcinoma precursors: presentation of two cases and diagnostic issues

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Two reports exist positing a precursor lesion for endometrial clear cell carcinoma like that of SEIC as noted in association with ESC. One utilizes the term “Endometrial Intraepithelial carcinoma, clear cell type,” describing the lesion as markedly atypical glands overlying a basement membrane with clear cytoplasm, coarse chromatin, irregular nuclear membranes, and prominent nucleoli ( Moid and Berezowski, 2004 ). Another coins the term “Clear cell Endometrial Intraepithelial carcinoma,” a report which describes atrophic glands with large, atypical cells, large round to oval nuclei with size greater than three times that noted in adjacent, background endometrium, and clear cytoplasm ( Ishida et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Variants of in situ carcinoma of the endometrium: Clear cell and gastrointestinal types, with a review of the literature

Abada¹,

Banet²,

Quddus³

2022

Gynecologic Oncology Reports

View full text Add to dashboard Cite

“…In 2004, Moid and Berezowski (Moid and Berezowski 2004) described a distinctive lesion in a hysterectomy specimen from a 70-year-old woman which they designated endometrial intraepithelial carcinoma, clear cell type (EIC, clear cell type). The lesion comprised surface epithelium and glands that were lined by cells with ''clear cytoplasm, marked nuclear pleomorphism, coarse chromatin, irregular nuclear membranes, and prominent eosinophilic nucleoli'' and an occasional hobnail appearance.…”

Section: Putative Precursor For Endometrial Clear Cell Carcinoma: Clear Cell Emgdmentioning

confidence: 99%

Intraepithelial Neoplasia

2009

View full text Add to dashboard Cite

She attended medical school in India (Meerut, UP) and graduated in 2001. She then specialized in Pathology at King Georges' Medical University, Lucknow (UP), receiving her postgraduate medical degree (MD) in 2007. As a medical student she received various recognitions in academic circles. For more than three years, she has been actively engaged in research at the National University of Singapore. Her areas of research include identifying biomarkers in patients at high risk of gastric cancer, prognostic biomarkers in hepatocellular carcinoma and cervical carcinoma and identifying the origin of Barrett's Oesophagus. She is also involved in research projects involving confocal laser endomicroscopy of the gastrointestinal tract and Laser Capture Microdissection, and has been an author and co-author in various papers on topics within her research interest. ContentsPreface XIII Part Intraepithelial Neoplasia of Oral Cavity 1

show abstract

Pathologic Quiz Case: A 70-Year-Old Woman With Postmenopausal Bleeding

Cited by 8 publications

References 5 publications

Clear cell endometrial carcinoma precursors: presentation of two cases and diagnostic issues

Clear cell endometrial carcinoma precursors: presentation of two cases and diagnostic issues

Variants of in situ carcinoma of the endometrium: Clear cell and gastrointestinal types, with a review of the literature

Intraepithelial Neoplasia

Contact Info

Product

Resources

About