Pathologic Quiz Case 1

Rankin, Brett S.; Millay, Donna J.; Lunde, John H.

doi:10.1001/archotol.124.2.218

Cited by 2 publications

(2 citation statements)

References 5 publications

(9 reference statements)

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“…Cytokeratin is the most useful marker to differentiate between neural and epithelial neuroendocrine tumors. The use of immunostains, electromicroscopy, and molecular genetics has helped to understand this lesion, but the mainstay of diagnosis of this tumor remains to be the light microscopy [ 4 , 10 ]. SNEC is exceptionally rare and it is important to differentiate from sinonasal undifferentiated carcinoma (SNUC) which are distinctly larger, with more prominent eosinophilic cytoplasm and larger nuclei, often with prominent nucleoli by light miscopy [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

An Extremely Rare Case of Advanced Metastatic Small Cell Neuroendocrine Carcinoma of Sinonasal Tract

Thar

Patel

Huang

et al. 2016

Case Reports in Oncological Medicine

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Small cell neuroendocrine carcinoma (SNEC) is a rare form of malignancy. It mainly presents as bronchogenic neoplasm, and the extrapulmonary form accounts for only 0.1% to 0.4% of all cancers. These extrapulmonary tumors have been described most frequently in the urinary bladder, prostate, esophagus, stomach, colon and rectum, gall bladder, head and neck, cervix, and skin. Primary SNEC of the sinonasal tract is extremely rare with only less than 100 cases reported in the literature. Because of extreme rarity and aggressiveness of the tumor, the management for this entity varies considerably mandating multimodality approach. In this paper, we report a patient presented with left-sided facial swelling, and the histopathologic examination confirmed primary SNEC of left sinonasal tract. The tumor involved multiple paranasal sinuses with invasion into the left orbit and left infratemporal fossa and metastasized to cervical lymph nodes and bone. The patient encountered devastating outcome in spite of optimal medical management and treatment with palliative chemotherapy highlighting the necessity for further research of primary SNEC of head and neck.

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Section: Discussionmentioning

confidence: 99%

An Extremely Rare Case of Advanced Metastatic Small Cell Neuroendocrine Carcinoma of Sinonasal Tract

Thar

Patel

Huang

et al. 2016

Case Reports in Oncological Medicine

View full text Add to dashboard Cite

show abstract

“…In contrast, well-differentiated neuroendocrine carcinomas have variable and most often indolent biologic behaviors [5]. Histologically, well-differentiated neuroendocrine carcinomas show uniform and small cells organized in organoid or trabecular architecture [6]. Subtypes of well-differentiated neuroendocrine carcinomas include typical carcinoid tumors, pancreatic islet cell (neuroendocrine) tumors, paragangliomas, pheochromocytomas, and medullary thyroid carcinomas [5].…”

Section: Discussionmentioning

confidence: 99%