Pathologic prognostic factors in Barrett's-associated adenocarcinoma

Torres, Carlos; Turner, Jerrold R.; Wang, Helen H.; Richards, William G.; Sugarbaker, David J.; Shahsafaei, Aliakbar; Odze, Robert D.

doi:10.1002/(sici)1097-0142(19990201)85:3<520::aid-cncr2>3.0.co;2-l

Cited by 38 publications

(10 citation statements)

References 30 publications

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“…In general, the significantly different expression rate in EAC and ESCC underlines the biologic divergence between the two types of EC tumors, which were assumed to behave in a similar fashion for a long time [29,30]. As a consequence, the recently published, 7th AJCC/UICC classification has proposed different prognostic staging groups for EAC and ESCC [31].…”

Section: Discussionmentioning

confidence: 99%

CXCR7 expression in esophageal cancer

Tachezy

Zander

Gebauer

et al. 2013

Journal of Translational Medicine

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BackgroundThe chemokine CXCL12 and its receptor CXCR4 play a major role in tumor invasion, proliferation and metastasis in different malignant diseases, including esophageal carcinoma, amongst others. CXCR7 was recently identified as a novel alternate receptor for CXCL12. The aim of this study was to evaluate the prognostic impact of expression of chemokine receptor CXCR7 in patients with esophageal carcinoma (EC).MethodsExpression of CXCR7 in primary tumors, lymph nodes and distant metastases of 299 patients with EC was evaluated by immunohistochemistry on a tissue microarray and compared with clinical and histopathological data.ResultsIn esophageal cancer sections, CXCR7-specific reactivity was apparent in 45% of the squamous cell carcinomas (ESCC), but only occasionally in adenocarcinomas. No correlation between CXCR4 and CXCR7 expression was evident. We correlated expression with clinical and histopathological characteristics, but could not find any association.ConclusionsContrary to the other known CXCL12 receptor, CXCR4, CXCR7 is expressed in ESCC only, underlining the divergent mechanisms and backgrounds of EAC and ESCC. The results of the study do not indicate a significant functional role for CXCR7 in EAC or ESCC of the esophagus. However, its variable expression in the main two main types of EC needs to be further investigated.

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Section: Discussionmentioning

confidence: 99%

CXCR7 expression in esophageal cancer

Tachezy

Zander

Gebauer

et al. 2013

Journal of Translational Medicine

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“…Although diagnostic and surgical techniques have been advanced, survival rates have not been improved in the last decade, and the 5-year survival rate of patients with surgically treated oesophageal cancer remains less than 50% in spite of three-field lymph node dissection and combination chemotherapy and radiotherapy (Torres et al, 1999;Adham et al, 2000;Ando et al, 2000;Collard et al, 2001).…”

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confidence: 99%

Overexpression of hypoxia-inducible-factor 1α(HIF-1α) in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage

et al. 2003

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The purpose of this study is to investigate the clinical and histopathologic significance of hypoxia-inducible-factor 1a (HIF-1a) expression in oesophageal squamous cell carcinoma. One hundred and thirty surgically resected specimens of OSCC were immunohistochemically assessed for HIF-1a expression with monoclonal antibody. High HIF-1a immunostaining was detected in 40 specimens . The percentage of high HIF-1a expression cases increased with tumour stage according to pTNM system. High HIF-1a expression correlated with pTNM stage , depth of tumour invasion, lymph node metastasis, distant metastasis, lymphatic invasion and positive surgical margin. The overall survival rate was worse in patients with high HIF-1a pattern than in patients with low-expression pattern. Univariate analyses identified high HIF-1a positivity, depth of tumour invasion, lymph node metastasis, distant metastasis, lymphatic invasion, and a positive surgical margin as risk factors. Multivariate analyses indicated that depth of tumour invasion, lymph node metastasis and positive surgical margin, but not HIF-1a, were independent prognostic factors. Survival in patients with a high HIF-1a expression was significantly worse than in those with low expression in patient treated with adjuvant therapy.

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“…It remains controversial whether there is a clear survival advantage with the use of chemrad (1)(2)(3)(4)(5). However, recent prospective studies have shown increased survival after chemrad if given before surgical resection (4 -6).…”

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confidence: 99%

Gastric Dysplasia-Like Epithelial Atypia Associated with Chemoradiotherapy for Esophageal Cancer: A Clinicopathologic and Immunohistochemical Study of 15 Cases

2001

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Preoperative chemotherapy combined with radiotherapy (chemrad) is a common type of neoadjuvant treatment for esophageal adenocarcinoma or squamous cell carcinoma. The purpose of this study was to describe the clinical, histologic, proliferative (MIB-1), and oncogenetic (p53) features of 15 patients with gastric dysplasia-like epithelial atypical changes associated with preoperative chemrad for esophageal cancer. Two of these cases were initially misinterpreted as dysplasia, which led to partial gastrectomy. The findings were compared with 12 age-and sex-matched patients with known gastric dysplasia. Cases with gastric dysplasia-like epithelial atypia were significantly associated with a flat gross appearance, a patchy distribution, foveolar and gland involvement, surface maturation, an open nuclear chromatin pattern with prominent nucleoli, retention of nuclear polarity, mitoses confined to the pits, lack of atypical mitoses, cytoplasmic hypereosinophila and/or vacuolization, a lack of association with intestinal metaplasia, and finally, irregular glandular microcystic change, in comparison to the dysplasia controls. Furthermore, the study cases showed MIB-1 positivity restricted to the deep foveolar epithelium and an absence of p53 staining in 14 of 15 cases, in contrast to the dysplasia controls, in which MIB-1 stained both the deep and superficial foveolar epithelium and surface epithelium, and p53 was positive in all cases (100%). In summary, a number of histologic and immunohistochemical features may distinguish gastric dysplasia-like epithelial atypia associated with chemrad for esophageal cancer from true dysplasia. Pathologists should be aware of this entity and its histologic and immunohistochemical features to avoid misinterpretation and prevent unnecessary treatment.

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Pathologic prognostic factors in Barrett's-associated adenocarcinoma

Cited by 38 publications

References 30 publications

CXCR7 expression in esophageal cancer

CXCR7 expression in esophageal cancer

Overexpression of hypoxia-inducible-factor 1α(HIF-1α) in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage

Gastric Dysplasia-Like Epithelial Atypia Associated with Chemoradiotherapy for Esophageal Cancer: A Clinicopathologic and Immunohistochemical Study of 15 Cases

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