Pathologic pain distorts visuospatial perception

Sumitani, Masahiko; Shibata, Masahiko; Iwakura, Tateo; Matsuda, Yoichi; Sakaue, Gaku; Inoue, T; Mashimo, Takashi; Miyauchi, Satoru

doi:10.1212/01.wnl.0000250335.56958.f0

Cited by 85 publications

(72 citation statements)

References 10 publications

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“…the unilateral pain [36]. Neglect symptoms reduced after the application of nerve blocks, and a similar trend was shown in healthy participants [36].…”

Section: An Impaired Perception Of Space Not Limited To the Side Of Tsupporting

confidence: 60%

“…After prism adaptation, visual body midline judgments erred in the opposite direct, towards the side of the unaffected side [35]. In contrast to previous studies [5][6][7]16,24,25,34], these latter experiments [35,36,38] demonstrated that the side for which there is a diminished representation of space does not always correspond to that of the affected limb.…”

Section: An Impaired Perception Of Space Not Limited To the Side Of Tmentioning

confidence: 57%

“…the unilateral pain [36]. Neglect symptoms reduced after the application of nerve blocks, and a similar trend was shown in healthy participants [36]. In addition, the shift toward the hemispace of the affected limb during visual straight-ahead estimations can be efficiently reduced by prism adaptation [35].…”

Section: An Impaired Perception Of Space Not Limited To the Side Of Tmentioning

confidence: 59%

“…CRPS patients can bias the perception of space towards, and not away from, their affected limb [35,36,38]. Sumitani et al [36] have used a visual subjective body midline judgment task known to produce errors toward the ipsilesional hemispace in brain-damaged neglect patients (e.g.…”

Section: An Impaired Perception Of Space Not Limited To the Side Of Tmentioning

confidence: 99%

“…[32]). As compared to hemineglect consecutive to brain damage, a different strategy was proposed in CRPS: the prism intervention is aimed at shifting spatial frames away from the affected side [35,36]. After prism adaptation, visual body midline judgments erred in the opposite direct, towards the side of the unaffected side [35].…”

Section: An Impaired Perception Of Space Not Limited To the Side Of Tmentioning

confidence: 99%

See 4 more Smart Citations

Pain, body, and space: What do patients with complex regional pain syndrome really neglect?

Legrain

Bultitude

Paepe

et al. 2012

Pain

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“…the unilateral pain [36]. Neglect symptoms reduced after the application of nerve blocks, and a similar trend was shown in healthy participants [36].…”

Section: An Impaired Perception Of Space Not Limited To the Side Of Tsupporting

confidence: 60%

Section: An Impaired Perception Of Space Not Limited To the Side Of Tmentioning

confidence: 57%

Section: An Impaired Perception Of Space Not Limited To the Side Of Tmentioning

confidence: 59%

Section: An Impaired Perception Of Space Not Limited To the Side Of Tmentioning

confidence: 99%

Section: An Impaired Perception Of Space Not Limited To the Side Of Tmentioning

confidence: 99%

See 3 more Smart Citations

Pain, body, and space: What do patients with complex regional pain syndrome really neglect?

Legrain

Bultitude

Paepe

et al. 2012

Pain

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Complex Regional Pain Syndrome

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Head

2010

Evidence‐Based Chronic Pain Management

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Dystonia in complex regional pain syndrome (CRPS) responds poorly to treatment. Intrathecal baclofen (ITB) may improve this type of dystonia, but information on its efficacy and safety is limited. A singleblind, placebo-run-in, dose-escalation study was carried out in 42 CRPS patients to evaluate whether dystonia responds to ITB. Thirty-six of the 38 patients, who met the responder criteria received a pump for continuous ITB administration, and were followed up for 12 months to assess long-term efficacy and safety (open-label study). Primary outcome measures were global dystonia severity (both studies) and dystonia-related functional limitations (open-label study). The dose-escalation study showed a doseeffect of baclofen on dystonia severity in 31 patients in doses up to 450 lg/day. One patient did not respond to treatment in the dose-escalation study and three patients dropped out. Thirty-six patients entered the open-label study. Intention-to-treat analysis revealed a substantial improvement in patient and assessor-rated dystonia scores, pain, disability and quality-of-life (Qol) at 12 months. The response in the dose-escalation study did not predict the response to ITB in the open-label study. Eighty-nine adverse events occurred in 26 patients and were related to baclofen (n = 19), pump/catheter system defects (n = 52), or could not be specified (n = 18). The pump was explanted in six patients during the followup phase. Dystonia, pain, disability and Qol all improved on ITB and remained efficacious over a period of one year. However, ITB is associated with a high complication rate in this patient group, and methods to improve patient selection and catheter-pump integrity are warranted.

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Altered tactile localization and spatiotemporal integration in complex regional pain syndrome patients

Trojan

Speck

Kleinböhl

et al. 2018

European Journal of Pain

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Background In complex regional pain syndrome (CRPS), altered perception of the affected hand and neglect‐like symptoms of the affected body side are common features. In this study, we presented tactile stimuli to the affected hands in CRPS patients and matched healthy controls. Methods The participants’ task was to point at the perceived positions of the stimuli using a tracking device. The spatial coordinates of the perceived positions were analysed for accuracy and consistency. We also presented patterns consisting of two stimuli at distinct positions with a delay of 100 ms. These patterns are known to induce spatiotemporal integration (“sensory saltation”). Results CRPS patients were less accurate and less consistent in the spatial perception of tactile stimuli on their hands. Furthermore, they showed increased spatiotemporal integration, although these effects were smaller than expected. These deficiencies were related to the clinically assessed intensity of recurrent pain episodes. Surprisingly, the intensity of clinically assessed ongoing pain was associated with increased precision. Conclusions In line with earlier reports, our findings indicate that the representation of the affected hands in CRPS patients is less accurate than in healthy people, probably reflecting reorganization in somatosensory cortices. The exact relationships between these findings and other aspects of CRPS remain to be elucidated. Significance CRPS patients performed poorly in localizing positions on their affected hands via pointing and exhibited increased spatiotemporal integration. The presented method may prove useful in diagnostics as well as psychophysical and neurofunctional research on CRPS and other chronic pain disorders.

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Pathologic pain distorts visuospatial perception

Cited by 85 publications

References 10 publications

Pain, body, and space: What do patients with complex regional pain syndrome really neglect?

Pain, body, and space: What do patients with complex regional pain syndrome really neglect?

Complex Regional Pain Syndrome

Altered tactile localization and spatiotemporal integration in complex regional pain syndrome patients

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