Pathologic N1 disease in lung cancer: the segmental and subsegmental lymph nodes

Extended Pleurectomy/Decortication for Malignant Pleural Mesothelioma: Humanitas’s Experience

“…Our data support the eighth TNM classification where only two N categories (N1 and N2) remain. This N category reclassification is due to the fact that intrapleural and extrapleural nodes are now grouped into category N1 because it seems that for MPM, survival is more affected by the number of nodes involved than by the specific anatomical locations of nodal disease as in lung cancer [ 40 , 41 , 42 , 43 , 44 ].…”

Lymph node dissection in the left upper lobe: clinical outcomes and surgical techniques in Japan

“…The metastasized pN1 was divided into two groups: the first group implies uninvolvement of lymph node (pN0) in the inner side of the lobe [peripheral zone (lobar #12 i.e., LOB#12, segmental #13, and subsegmental #14)], and the other group implies behavior similar to that of early-stage pN2 disease [hilar/interlobar zone (stations #10 and #11; HIL#10 and INT#11)] ( 12 ). Okada et al have reported equivalent prognoses between hilar N1 disease and N2 single-station disease ( 13 ).…”

“…Okada et al have reported equivalent prognoses between hilar N1 disease and N2 single-station disease ( 13 ). Several authors have reported that the outcomes were significantly better with pN1 involvement in hilar N1 disease than in N2 single-station disease ( 12 , 14 ). Wang et al have reported that HIL#10 metastasis was significant for the LPT#4L metastasis on multivariate analyses ( 10 ).…”

Perspective and clinical relevance of intrapulmonary lymph node retrieval: response to the editorial by Tantraworasin and colleagues and the editorial by Marc Riquet and colleagues

“…Academic discussion about clinical relevance of intrapulmonary lymph node retrieval will help the community to increase the awareness of this easy-to-be-neglected area in our practice. Dr. Tantraworasin et al (1) and Dr. Riquet et al (2) both contribute their thoughts on this important topic. As they mentioned in the editorials, these lymph nodes deserve special attention because they occupy a unique place not only with regard to the prognosis of the NSCLCs when they are metastatic but also because of their anatomical and pathogenic characteristics (2).…”

“…Dr. Tantraworasin et al (1) and Dr. Riquet et al (2) both contribute their thoughts on this important topic. As they mentioned in the editorials, these lymph nodes deserve special attention because they occupy a unique place not only with regard to the prognosis of the NSCLCs when they are metastatic but also because of their anatomical and pathogenic characteristics (2). These comments will surely encourage more and more investigation around this topic.…”