Pathologic findings and association of Mycobacterium bovis infection with the bovine NRAMP1 gene in cattle from herds with naturally occurring tuberculosis

Barthel, Robert; Piedrahita, Jorge A.; McMurray, David N.; Payeur, Janet B.; Baca, D.; Güemes, Francisco Suárez; Perumaalla, Veera S.; Ficht, Thomas A.; Templeton, Joe W.; Adams, L. Garry

doi:10.2460/ajvr.2000.61.1140

Cited by 43 publications

(44 citation statements)

References 17 publications

(25 reference statements)

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“…The white doves had a lower prevalence of infection, fewer infected organs affected and a different pattern of inflammation as compared with the coloured doves. These data are consistent with epidemiological and genetic studies showing immune response polymorphism to mycobacterial infections in humans and other mammals (Bellamy, 2005;Dorman et al, 2004;Barthel et al, 2000;Pan et al, 2005;Di Pietrantonio & Schurr, 2005) and in different strains of chickens (Hu et al, 1997;Bacon et al, 2000). Specific genes that have been associated with differing immune responses to mycobacterial infections include those that code for the major histocompatability receptors, cytokines, T-cell receptors, immunoglobulins and NRAMP1 (Zekarias et al, 2002).…”

Section: Discussionsupporting

confidence: 74%

“…Both environmental and genetic factors and their interaction influence susceptibility to tuberculosis in humans (Casanova & Abel, 2002;Schurr, 2007), in laboratory animals such as rabbits and mice, and in domestic mammals (Barthel et al, 2000;Phillips et al, 2002;Di Pietrantonio & Schurr, 2005;Dannemberg, 2006). For example, in humans infected with M. tuberculosis, less than 10% of infections progress to clinical disease (Cole et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Mycobacteriosis in naturally infected ring-neck doves (Streptopelia risoria): investigation of the association between feather colour and susceptibility to infection, disease and lesions type

Saggese

Tizard²,

Phalen

2008

Avian Pathology

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Mycobacteriosis in naturally infected ring-neck doves (Streptopelia risoria): investigation of the association between feather colour and susceptibility to infection, disease and lesions type

Saggese

Tizard²,

Phalen

2008

Avian Pathology

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“…The fragment described by Hořín et al (1999) was amplified using the primers and PCR conditions described by the same author. The (GT) n microsatellite of Adams and Templeton (1998) was analyzed using the primers and PCR conditions described by Barthel et al (2000). The SNP were genotyped using SNPlex technology by Applied Biosystems.…”

Section: Genetic Association Studymentioning

confidence: 99%

Identification of single nucleotide polymorphisms in the bovine solute carrier family 11 member 1 (SLC11A1) gene and their association with infection by Mycobacterium avium subspecies paratuberculosis

Ruiz-Larrañaga

Garrido

Manzano

et al. 2010

Journal of Dairy Science

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Johne's disease is a chronic enteritis caused by Mycobacterium avium ssp. paratuberculosis (MAP) that causes substantial financial losses for the cattle industry. Susceptibility to MAP infection is reported to be determined in part by genetic factors, so markerassisted selection could help to obtain bovine populations that are increasingly resistant to MAP infection. Solute carrier family 11 member 1 (SLC11A1) was adjudged to be a potential candidate gene because of its role in innate immunity, its involvement in susceptibility to numerous intracellular infections, and its previous association with bovine MAP infection. The objectives of this study were to carry out an exhaustive process of discovery and compilation of polymorphisms in SLC11A1 gene, and to perform a population-based genetic association study to test its implication in susceptibility to MAP infection in cattle. In all, 57 single nucleotide polymorphisms (SNP) were detected, 25 of which are newly described in Bos taurus. Twenty-four SNP and two 3′-untranslated region polymorphisms, previously analyzed, were selected for a subsequent association study in 558 European Holstein-Friesian animals. The SNP c.1067C > G and c.1157-91A > T and a haplotype formed by these 2 SNP yielded significant association with susceptibility to MAP infection. The c.1067C > G is a nonsynonymous SNP that causes an amino acid change in codon 356 from proline to alanine (P356A) that could alter SLC11A1 protein function. This association study supports the involvement of SLC11A1 gene in susceptibility to MAP infection in cattle. Our results suggest that SNP c.1067C > G may be a potential causal variant, although functional studies are needed to assure this point.

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“…Indeed, Barthel and colleagues reported that polymorphic alleles in the 3'UTR (GT)n microsatellite of the SLC11A1 gene do not affect resistance or susceptibility to infection by M. bovis in cattle [24]. Importantly, the susceptible phenotype is due to a nucleotide substitution that results in an amino acid change, rather than polymorphisms in the 3'UTR (GT)n microsatellite sequences.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Bovine SLC11A1 (Formerly NRAMP1) Polymorphisms to the Risk of Bovine Tuberculosis in Holstein Cattle

Cheng

Huang²,

Tsai³

2015

J Veterinar Sci Technol

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Many studies suggest significant genetic variation in the resistance of cattle and humans to infection with Mycobacterium bovis, the causative agent of zoonotic tuberculosis. The natural resistance associated macrophage protein 1 (NRAMP1), encoded by the SLC11A1 gene, plays a key role in the immunological control of a broad spectrum of infectious agents. The aim of the present study was to investigate the influence of single nucleotide polymorphisms (SNPs) of the SLC11A1 gene on bovine tuberculosis (bTB) susceptibility. We genotyped the SLC11A1 gene in 60 bTB-infected Holstein cows and 90 healthy control animals. The influence in the exon 4 and intron 4 regions of SLC11A1 genetic variations on bTB susceptibility was subsequently investigated by association analysis. Our finding demonstrated that the g.107117166A>G and g.107117369C>T polymorphisms of the SLC11A1 gene associated with bTB in Holstein cattle. The susceptibility of cattle with the g.107117166A>G genotype compared with the GG genotype was 3.40 (95% CI: 1.10-10.51; p=0.048) fold higher. The g. 107117166A>G SNP located in the exon 4 of the SLC11A1 gene and the functional consequence was missense. The deduced amino acid sequence for the protein product revealed an alanine to threonine conversion at position 96, which may affect initiation of protein synthesis and disrupt normal NRAMP1 function that protects animals against mycobacterial infection. The other susceptibility of cattle with the g.107117369C>T genotype compared with the TT genotype was 0.26 (95% CI: 0.12-0.56; p=0.001) fold lower. The g.107117369C>T polymorphism, located in the intron 4 of the SLC11A1 gene, may affect elements that control transcription and splicing of the NRAMP1 leading to affect pathophysiological characteristics in tuberculosis. This is the first report showing that the g. 107117166A>G and g.107117369C>T polymorphisms may contribute to SLC11A1-mediated bTB susceptibility.

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Pathologic findings and association of Mycobacterium bovis infection with the bovine NRAMP1 gene in cattle from herds with naturally occurring tuberculosis

Abstract: The NRAMP1 gene does not determine resistance and susceptibility to infection with M bovis in cattle.

Cited by 43 publications

References 17 publications

Mycobacteriosis in naturally infected ring-neck doves (Streptopelia risoria): investigation of the association between feather colour and susceptibility to infection, disease and lesions type

Mycobacteriosis in naturally infected ring-neck doves (Streptopelia risoria): investigation of the association between feather colour and susceptibility to infection, disease and lesions type

Identification of single nucleotide polymorphisms in the bovine solute carrier family 11 member 1 (SLC11A1) gene and their association with infection by Mycobacterium avium subspecies paratuberculosis

Relationship of Bovine SLC11A1 (Formerly NRAMP1) Polymorphisms to the Risk of Bovine Tuberculosis in Holstein Cattle

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