Pathologic Features of Small Hepatocellular Carcinoma

Kondō, Yōichirō; Kondo, Fukuo; Wada, Kodai; Okabayashi, Atsushi

doi:10.1111/j.1440-1827.1986.tb02836.x

Cited by 12 publications

(8 citation statements)

References 9 publications

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“…There is increased basophilic or eosinophilic cytoplasmic staining, which may be of diagnostic use. 21 For unknown reasons, tumor cells have a remarkable tendency to undergo fatty changes or clear cells alterations, especially in small nodules. Similar findings were also observed by Kojiro et al 22 In this study, BHC-treated liver showed small to large hepatocytes with enlarged nucleus and bigger nucleoli.…”

Section: Discussionmentioning

confidence: 99%

Potency of Andrographolide as an Antitumor Compound in BHC-Induced Liver Damage

2009

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Relevance. The present investigation relates to the influence of andrographolide, an active compound of Andrographis paniculata Nees. It reverses an experimental liver carcinogenic condition of mice to normal and might be a potential therapeutic/preventive agent for human liver cancer. Objective. A. paniculata (Kalmegh) is extensively used in the Indian traditional system of medicine as a hepatoprotective and hepatostimulative agent and has been reported to have protective effect against different hepatotoxins. Materials and methods. Histomorphological, ultrastructural, and biochemical studies were performed for the effect of the andrographolide on control mice, mice treated with hexachlorocyclohexane (BHC) only and BHC + andrographolide. Enzymes for liver function tests were analyzed by spectrophotometric method. Results. The BHC experimental model forms an irreversible liver tumor in male mice. The histological and ultrastructural changes observed in andrographolide supplementation emphasize the recovery of the damaged liver. This recovery was also reflected in the neoplastic nodule formation. The activity of phosphorylase and glucose-6-phosphatase in the liver of the andrographolide-supplemented group suggests improved glycogenolysis in liver. Serum glutamate pyruvate transaminase, serum glutamate oxalate transaminase, alkaline phosphatase, acid phosphatase, and γ-glutamyl transpeptidase showed a significant decrease in andrographolide-supplemented animals as compared with BHC-treated animals, suggesting regenerative effects elicited by andrographolide. Conclusion. The study indicates that the regenerative capability elicited by andrographolide is possibly due to its ability to reactivate liver function enzymes that catalyze the reaction of several biochemical and synthetic processes and that it may be useful for severe liver damage conditions.

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Section: Discussionmentioning

confidence: 99%

Potency of Andrographolide as an Antitumor Compound in BHC-Induced Liver Damage

2009

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“…However, some patients who could not obtain a treated margin ≥5 mm showed definite local recurrence. This may have been due to incomplete necrosis of the marginal tumor area including microscopic metastasis adjacent to the primary tumor (10)(11)(12). Therefore, the treated margin of ≥5 mm should be obtained to eliminate tumor cells at the periphery and reduce the incidence of local recurrence (13,14).…”

Section: Discussionmentioning

confidence: 99%

Percutaneous microwave coagulation therapy for hepatocellular carcinoma: Increased coagulation diameter using a new electrode and microwave generator

Inokuchi

Seki²,

Ikeda³

et al. 2010

Oncol Rep

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Abstract. We performed percutaneous microwave coagulation therapy (PMCT) using a new microwave electrode and microwave generator to lessen the number of microwave electrode insertions for hepatocellular carcinoma (HCC) measuring ≤3.0 cm in diameter. In this study, we assessed the efficacy of this new system. Fifty-two patients with liver cirrhosis and HCC measuring ≤3.0 cm in diameter (tumor size: ≤2 cm, 27 patients; >2 to ≤2.5 cm, 13 patients; >2.5 to ≤3 cm, 12 patients) underwent PMCT using a new microwave coagulation system under ultrasonographic guidance. Fortytwo of 52 patients showed complete necrosis of the tumor lesion with a treated margin ≥5 mm on dynamic computed tomography. Necrosis of HCC and the non-cancerous area surrounding the tumor was obtained by a single needle insertion in 23 patients (tumor size: ≤2 cm, 23 patients), by two needle insertions in 11 patients (tumor size: ≤2 cm, 4 patients; >2 to ≤2.5 cm, 5 patients; >2.5 to ≤3 cm, 2 patients), and by three needle insertions in 8 patients (tumor size: >2 to ≤2.5 cm, 5 patients; >2.5 to ≤3 cm, 3 patients). During the follow-up period of 5-34 months, all patients remained alive. Among the patients showing complete necrosis of HCC with a treated margin ≥5 mm, we have not detected local recurrences. On the other hand, 4 of the 10 patients who could not obtain the treated margin of ≥5 mm, experienced a local recurrence. No fatal complications were observed. However, bile duct stricture was observed in 2 patients. The new microwave coagulation system can induce extensive necrosis with a small number of microwave electrode insertions. This system may enhance the efficacy of PMCT for HCC measuring <3.0 cm in diameter.

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“…Stromal invasion, formerly called interstitial invasion [13,14], is defined as invasive growth of tumor tissue into fibrous septa, portal tracts, and/or blood vessels [13][14][15][16][17]. It is histologically classified into 3 types: crossing, longitudinal, and irregular ( Fig.…”

Section: Histological Diagnosis Of Early Hccs Of Resected or Autopsiementioning

confidence: 99%

Histological features of early hepatocellular carcinomas and their developmental process: for daily practical clinical application

Kondo

2008

Hepatol Int

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Based on clinical and pathological experience, indistinct margin-type hepatocellular carcinomas (HCCs) were considered to be typical early-stage HCCs with good prognosis. For histological diagnosis, the assessment of stromal invasion (tumor invasion into portal tracts and fibrous septa) is very important. In differentiating stromal invasion from pseudoinvasion (benign hepatic tissue in the fibrous stroma), the following 5 items are useful: (1) macroscopic or panoramic views of the histological specimen, (2) amount of fibrous components of the stroma, (3) destruction of the structure of portal tracts, (4) loss of reticulin fibers around cancer cells, and (5) cytokeratin 7 immunostaining for ductular proliferation. Parenchymal features of early HCCs are summarized as follows: (1) thin trabecular structure, (2) hypercellularity, (3) hyperstainability of cytoplasm, and (4) microacinar formation. Detailed understanding of the total biopsy procedure and various difficult lesions is necessary for a correct biopsy diagnosis. Evaluation of noncancerous tissue is also required to attain a better understanding of the developmental process and clinical stages of HCCs.

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Pathologic Features of Small Hepatocellular Carcinoma

Cited by 12 publications

References 9 publications

Potency of Andrographolide as an Antitumor Compound in BHC-Induced Liver Damage

Potency of Andrographolide as an Antitumor Compound in BHC-Induced Liver Damage

Percutaneous microwave coagulation therapy for hepatocellular carcinoma: Increased coagulation diameter using a new electrode and microwave generator

Histological features of early hepatocellular carcinomas and their developmental process: for daily practical clinical application

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