Pathologic Features of Prognostic Significance in Adrenocortical Carcinoma

Weiss, Lawrence M.; Medeiros, L. Jeffrey; Vickery, Austin L.

doi:10.1097/00000478-198903000-00004

Cited by 726 publications

(502 citation statements)

References 0 publications

Supporting

Mentioning

461

Contrasting

Unclassified

Order By: Relevance

“…Tissue specimens of ACC were obtained during surgery, and fixed in 10% formalin and embedded in paraffin wax. The diagnosis of ACC was made by two pathologists (TS and HS) according to the criteria of Weiss [6,7].…”

Section: Patients Tissue Specimens and Follow-upmentioning

confidence: 99%

“…The diagnosis of ACC has been made according to the criteria of Weiss [6,7], which is a well-validated and established scoring system for a histopathological diagnosis of ACC [1,8]. ACC is documented to dem-onstrate high recurrence rate of up to 85% [1,9], and histological and molecular markers for prediction of tumor behavior are therefore considered to be one of major concerns.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Immunohistochemistry of a Proliferation Marker Ki67/MIB1 in Adrenocortical Carcinomas: Ki67/MIB1 Labeling Index Is a Predictor for Recurrence of Adrenocortical Carcinomas

et al. 2008

View full text Add to dashboard Cite

Abstract. Adrenocortical carcinoma (ACC) is a rare, highly malignant tumor. The aim of the present study is to evaluate the prognostic relevance of a proliferation marker Ki67/MIB1 by immunohistochemistry in 17 cases who underwent resections of the primary tumors and diagnosed to have ACC at Tohoku University Hospital based on the criteria of Weiss during the period from 1976 to 2005. The follow-up periods ranged from 221 days to 10659 days (about 29 years) with the median of 1895 days. The median age at diagnosis was 46 years old, and the mean size of the primary tumors was 7.1 cm with the minimal of 3.5 cm. Ki67/MIB1 labeling index (Ki67/MIB1LI) ranged from 1% to 26%. Kaplan-Meier analysis revealed that patients with Ki67/MIB1LI of 7% or more were associated with significantly shortened disease-free survival (P = 0.0037). The evaluation with Weiss criteria revealed that the median score of Weiss criteria was five, and 13 patients (76.5%) presented positive findings in the criteria of mitotic rate. The survival analysis with Weiss score showed that patients with the scores of 6 or more had both significantly shortened disease-free survival (P = 0.0001) and overall survival (P = 0.0063). The present study has suggested that Ki67/MIB1LI, as well as Weiss score, is a useful predictor for tumor recurrence after resection of the primary tumors in patients with ACC.

show abstract

Section: Patients Tissue Specimens and Follow-upmentioning

confidence: 99%

mentioning

confidence: 99%

Immunohistochemistry of a Proliferation Marker Ki67/MIB1 in Adrenocortical Carcinomas: Ki67/MIB1 Labeling Index Is a Predictor for Recurrence of Adrenocortical Carcinomas

et al. 2008

View full text Add to dashboard Cite

show abstract

“…A Ki 67 index of 2.5 -5% is suggestible for an ACC (Wachenfeld et al, 2001;Sasano et al, 2006). Indeed scoring indices could reliably discriminate between malignant and benign tumours as proven by several studies (van Slooten et al, 1985;Weiss et al, 1989).…”

Section: Discussionmentioning

confidence: 91%

“…Histological diagnosis was confirmed by two experienced pathologists (AR, WS). Histopathological diagnosis and grading were done in accordance to Weiss, van Slooten and Hough (Hough et al, 1979;van Slooten et al, 1985;Weiss et al, 1989). Two patients did not reach a score, which indicate malignancy (P6 and P26), but revealed high Ki67-indexes of 10 and 30%.…”

Section: Patients and Pathologymentioning

confidence: 99%

Expression of the zinc-finger transcription factor Snail in adrenocortical carcinoma is associated with decreased survival

et al. 2008

View full text Add to dashboard Cite

In this study, we evaluate whether Snail is expressed in adrenocortical cancer (ACC) and if its expression is related to patient outcome. One of the best known functions of the zinc-finger transcription factor Snail is to induce epithelial-to-mesenchymal transition (EMT). Increasing evidence suggests that EMT plays a pivotal role in tumour progression and metastatic spread. Snail and E-cadherin expression were assessed by immunohistochemistry in 26 resected ACCs and real-time quantitative RT–PCR expression analysis was performed. Data were correlated with clinical outcome and in particular with overall patient survival. Seventeen of 26 (65%) ACC tumour samples expressed Snail when assessed by immunohistochemistry. Snail expression was neither detected in normal adrenocortical tissue, nor in benign adrenocortical adenomas. Expression levels were confirmed on the mRNA level by Real-Time–PCR. Survival rates were significantly decreased in Snail-positive tumours compared to Snail-negative tumours: 10 out of 16 vs one out of eight patients succumbed to disease after a median follow up of 14.5 and 28.5 months, respectively ( P =0.03). Patients with Snail-expressing ACCs presented in advanced disease (11 out of 12 vs 6 out of 14, P =0.01) and tend to develop distant metastases more frequently than patients with negative staining (7 out of 11 vs two out of eight, P =0.19). In conclusion, we describe for the first time that Snail is expressed in a large subset of ACCs. Furthermore, Snail expression is associated with decreased survival, advanced disease and higher risk of developing distant metastases.

show abstract

“…This includes high nuclear grade, >5 mitoses per 50 high-power fields, atypical mitotic figures, <25% of tumor cells are clear cells, diffuse architecture (>33% of tumor), necrosis, venous, sinusoidal and capsular invasion. 9 The presence of three or more criteria highly correlates with subsequent malignant behavior.…”

Section: Discussionmentioning

confidence: 99%

Aldosterone-Producing Adrenocortical Carcinoma with Co-Secretion of Cortisol and Estradiol: A Case Report

Lazaro¹,

Adorable-Wagan²

2018

JAFES

View full text Add to dashboard Cite

Aldosterone-producing adrenocortical carcinoma comprises less than 7% of all functioning adrenocortical carcinomas. We report a rare case of adrenocortical carcinoma with a clinical picture of primary aldosteronism and subclinical Cushing's syndrome and feminization. Complete surgical resection normalized blood pressures and aldosterone, cortisol and estradiol levels. Long-term monitoring is recommended with imaging and hormonal evaluation used as tumor markers for recurrence.

show abstract

Pathologic Features of Prognostic Significance in Adrenocortical Carcinoma

Cited by 726 publications

References 0 publications

Immunohistochemistry of a Proliferation Marker Ki67/MIB1 in Adrenocortical Carcinomas: Ki67/MIB1 Labeling Index Is a Predictor for Recurrence of Adrenocortical Carcinomas

Immunohistochemistry of a Proliferation Marker Ki67/MIB1 in Adrenocortical Carcinomas: Ki67/MIB1 Labeling Index Is a Predictor for Recurrence of Adrenocortical Carcinomas

Expression of the zinc-finger transcription factor Snail in adrenocortical carcinoma is associated with decreased survival

Aldosterone-Producing Adrenocortical Carcinoma with Co-Secretion of Cortisol and Estradiol: A Case Report

Contact Info

Product

Resources

About