Pathologic Features of Chronic Hepatitis

Ishak, Kamal G.

doi:10.1309/42d6-w7pl-fx0a-lbxf

Cited by 124 publications

(115 citation statements)

References 118 publications

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“…All sections were semi-quantitatively evaluated for necroinflammatory activity (0 ¼ none, 1 ¼ slight, 2 ¼ mild, 3 ¼ moderate, 4 ¼ marked, and 5 ¼ severe). The necroinflammatory activity is the evaluation of the presence and extent of focal necrosis, acidophilic bodies, piece meal necrosis (interface hepatitis), and confluent and bridging necrosis and the accompanying inflammatory infiltrate (lymphocytes, macrophages, neutrophils, and plasma cells) (Ishak 2000). Furthermore, the sections were semiquantitatively evaluated for fibrosis (0 ¼ none, 1 ¼ focal, 2 ¼ bridging, and 3 ¼ bridging with architectural distortion or cirrhosis), and copper content and distribution.…”

Section: Histopathologymentioning

confidence: 99%

A retrospective study of oral prednisolone treatment in canine chronic hepatitis

Favier

Poldervaart

Ingh³

et al. 2013

Veterinary Quarterly

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Background: Only one study reports prednisone to prolong survival in dogs with chronic hepatitis irrespective of the causative agent. The aim of this retrospective study was to investigate the effects of prednisolone treatment on survival, clinicopathological variables, and histological grade and stage of idiopathic chronic hepatitis in 36 dogs. Animals and methods: Medical records were reviewed of 36 prednisolone-treated dogs (median age: 8.6 years; range: 2.0-14.6 years) with chronic hepatitis not associated with primary copper accumulation. Clinicopathological results were analyzed pair-wise for 20 dogs, before and after oral prednisolone administration (1 mg/kg BW/day). Dogs were treated for at least 6 weeks, and for an additional 6 weeks if hepatitis was still present at rebiopsy. Follow-up data pertaining to clinical outcome and survival time (Kaplan-Meier estimate procedure) were analyzed. Results: At the follow-up, 11 dogs were in complete remission, 8 dogs had recurrent clinical signs, and 17 dogs had residual disease. Despite treatment, 20 dogs died of hepatitis-related causes. Dogs without cirrhosis survived significantly longer than dogs with cirrhosis. Prednisolone treatment normalized coagulopathies associated with chronic idiopathic hepatitis within one week in all 10 dogs that had coagulopathies at initial diagnosis. Conclusions: Our findings suggest that prednisolone has, in part, beneficial effects on hepatic inflammation and that it may, at least in some cases, limit the progression of fibrosis, which emphasizes the importance of early diagnosis and treatment. We did not see any benefit of prednisolone treatment for dogs with cirrhosis. We could document a highly favorable effect of prednisolone treatment on the coagulopathy associated with canine chronic idiopathic hepatitis.

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Section: Histopathologymentioning

confidence: 99%

A retrospective study of oral prednisolone treatment in canine chronic hepatitis

Favier

Poldervaart

Ingh³

et al. 2013

Veterinary Quarterly

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“…Histological activity was evaluated by the modified Ishak score (18). In patients who did not consent to liver biopsy, cirrhosis was diagnosed based on platelet count ≤ 100,000 mm 3 , on ultrasound features of surface nodularity, splenomegaly, and portal vein diameter > 13 mm (19), and in detecting esophageal varices at endoscopy.…”

Section: Definition Of Cirrhosismentioning

confidence: 99%

Outcome of chronic delta hepatitis in Italy: A long-term cohort study

Niro

Smedile

Ippolito

et al. 2010

Journal of Hepatology

130

109

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“…Damaged hepatocytes place is taken by the collagen fibers and lymphocytes forming cords which linking the neighboring portal spaces and/or portal spaces and centrilobular veins. Association of periportal necrosis in bridges indicates a rapid progression to cirrhosis, in which the formed bridges become dense collagen septum which disorganizes the lobular architecture, forming hepatocyte nodules (Ishak, 2000).…”

Section: Necroinflammatory Processmentioning

confidence: 99%