Pathologic Features of Acquired Immunodeficiency-Like Syndrome in Cats Experimentally Infected with Feline Immunodeficiency Virus.

Matsumura, Sei; Ishida, Takuo; Washizu, Tsukimi; Tomoda, Isamu; Nagata, Satoshi; Chiba, Joe; Kurata, Takeshi

doi:10.1292/jvms.55.387

Cited by 25 publications

(34 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…FIV causes immunodeficiency in cats and exhibits a course of disease progression, like that of HIV, which is unique when compared to other infectious diseases [15,16,20,21,33,37,45]. The clinical course of FIV infection consisted of five stages, including AP, AC, PGL, ARC and AIDS [16,33].…”

Section: Discussionmentioning

confidence: 99%

“…Two biological FIV strains, FIV-Petaluma and FIV-GA3 were used for experimental infection and inoculation [21]. FIV-Petaluma was isolated as the first FIV strain in a northern California cattery (derived from Dr. N. C. Pedersen, University of California, Davis, U.S.A.).…”

Section: Virusmentioning

confidence: 99%

“…The virus is a lentivirus capable of producing an acquired immunodeficiency syndrome (AIDS) in domestic cats with biologic characteristics similar to human immunodeficiency virus (HIV) [15,16,20,21,37,45]. The FIV-cat system is considered to be an attractive animal model for HIV infection [33], because of the pathogenic similarities between the two viruses including the disease course and the presence of T-cell immunodeficiency.…”

Section: Virusmentioning

confidence: 99%

“…Histopathologic findings in the lymph nodes, on the other hand, provide more accurate information for staging the disease [5,15,20,21,23,35,36]. The five stages, including follicular hyperplasia, mixed follicular hyperplasia and involution, follicular involution, mixed follicular involution and depletion, and follicular depletion, have been used to stage the lymph node lesions.…”

Section: Virusmentioning

confidence: 99%

See 3 more Smart Citations

Alteration of T-Cell Subsets in the Lymph Nodes from Cats Infected with Feline Immunodeficiency Virus

Endo

Matsumura

Washizu

et al. 1997

The Journal of Veterinary Medical Science

Self Cite

View full text Add to dashboard Cite

ABSTRACT. Alterations of T-cell subsets in the lymph nodes from FIV-infected cats in various clinical disease stages were examined histologically. In the early stage of infection (AP stage), follicular hyperplasia accompanied by expansion of the paracortical area was observed. Follicular involution and depletion with reduced paracortical area was observed in the ARC and AIDS stage nodes. The maximum section area of the entire popliteal lymph node was expanded significantly in the AP nodes. The paracortical area expanded in the AP nodes and decreased in the ARC and AIDS stage nodes. The cell density in the paracortical area in the AP nodes did not show a significant increase, while there was a significant reduction in the ARC and AIDS stage nodes. The lymph node CD4/CD8 ratio in the AP and ARC stages significantly decreased as compared with that of uninfected control cats, but conversion of the ratio was not seen. The estimated total numbers of CD4 + and CD8 + cells in the maximum section were increased in the AP stage but significantly decreased in the ARC and AIDS stages. Our study indicated that the lymphocyte depletion in the terminal ARC and AIDS stages of FIV infection was associated with both CD4 + cells and CD8 + cells. Findings obtained in this study might provide useful information for studying the pathophysiology of FIV infection. -KEY WORDS: CD4, CD8, feline immunodeficiency virus, lymph node.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Virusmentioning

confidence: 99%

Section: Virusmentioning

confidence: 99%

Section: Virusmentioning

confidence: 99%

See 2 more Smart Citations

Alteration of T-Cell Subsets in the Lymph Nodes from Cats Infected with Feline Immunodeficiency Virus

Endo

Matsumura

Washizu

et al. 1997

The Journal of Veterinary Medical Science

Self Cite

View full text Add to dashboard Cite

show abstract

“…Segue-se a isso um período de meses a anos, em que a infecção é assintomática. Linfadenomegalia generalizada, febre, anorexia, perda de peso e alterações comportamentais geralmente ocorrem com a progressão da infecção (Brown et al 1991, Matsumura et al 1993, Phillips et al 1996. Infecções crônicas secundárias ou associadas, causadas por agentes infecciosos comensais ou patogênicos são frequentes.…”

Section: Introductionunclassified

Características clínicas da fase aguda da infecção experimental de felinos pelo vírus da imunodeficiência felina

Zanutto

Froes

Teixeira³

et al. 2011

Pesq. Vet. Bras.

View full text Add to dashboard Cite

A infecção dos felinos pelo Vírus da Imunodeficiência Felina (FIV) resulta no desenvolvimento da síndrome de imunodeficiência dos felinos. Gengivite, perda de peso, linfadenomegalia generalizada, anemia, insuficiência renal crônica, complicações neurológicas, diarréia crônica e infecções bacterianas são encontradas frequentemente. A fase aguda da infecção pode ser assintomática, retardando o estabelecimento do diagnóstico e a implantação de medidas profiláticas para restringir o contágio e a transmissão do agente aos felinos suscetíveis. Com a finalidade de estudar as características clínicas da fase aguda da infecção, dez felinos jovens, sem definição racial, com oito meses de idade foram inoculados por via endovenosa com 1mL de sangue venoso de um gato portador do FIV subtipo B. A confirmação da infecção foi obtida através de teste sorológico em quatro e oito semanas pós-inoculação (p.i.) e por nested-PCR. Foram realizados hemogramas semanais, exame ultrassonográfico do abdômen quinzenais e exame oftalmológico mensal, durante doze semanas p.i. Discreta tendência a linfopenia na segunda semana p.i. e a neutropenia entre a quinta e sétima semana p.i., febre intermitente em alguns gatos, linfadenomegalia e hepato-esplenomegalia entre a quarta e a 12ª semana p.i. foram as alterações clínicas observadas. Apenas um gato apresentou uveíte unilateral direita. A fase aguda da infecção transcorreu com alterações clínicas inespecíficas. A linfadenomegalia e a hepato-esplenomegalia observadas no decorrer da infecção, refletindo hiperplasia linfóide, sugerem a necessidade de se realizar o teste sorológico para o FIV, em todos os gatos que se apresentarem com essas alterações, o que permitirá o diagnóstico precoce da infecção e a adoção de medidas profiláticas no sentido de minimizar a propagação da infecção.

show abstract

Viruses and Urinary Tract Disease

Kruger¹,

Osborne²,

Wise³

et al. 2011

Nephrology and Urology of Small Animals

View full text Add to dashboard Cite

Pathologic Features of Acquired Immunodeficiency-Like Syndrome in Cats Experimentally Infected with Feline Immunodeficiency Virus.

Cited by 25 publications

References 38 publications

Alteration of T-Cell Subsets in the Lymph Nodes from Cats Infected with Feline Immunodeficiency Virus

Alteration of T-Cell Subsets in the Lymph Nodes from Cats Infected with Feline Immunodeficiency Virus

Características clínicas da fase aguda da infecção experimental de felinos pelo vírus da imunodeficiência felina

Viruses and Urinary Tract Disease

Contact Info

Product

Resources

About