Pathologic Differentiation Between Radiosensitive and Nonradiosensitive Malignant Neoplasms of the Larynx

Harris, William C.; Klemperer, Paul

doi:10.1001/archotol.1938.00650040364004

Cited by 16 publications

(1 citation statement)

References 4 publications

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“…In this series we found no significant correla-ror. 5,17,[26][27][28][29] tion between histologic differentiation and T stage, but site and N stage were both statistically related to the grade. We found that recurrence at the primary site was more common in poorly differentiated tumors but not significantly so.…”

Section: The Criteria Used Have a Subjective Elementmentioning

confidence: 99%

Value of grading squamous cell carcinoma of the head and neck

et al. 1992

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We report a series of 3,294 patients with squamous cell carcinoma of the head and neck seen by one of us between 1963 and 1990. Two thousand and seven patients had a histologically proven and graded, but previously untreated, squamous cell carcinoma of the mucosal surfaces of the head and neck. These tumors had been graded previously by many different pathologists in many different hospitals, both in the United Kingdom and the United States, as well as continental Europe, over this period. Of the host factors both sex and age were associated with differentiation: 34% of patients less than age 50 had a well-differentiated tumor compared with 44% greater than age 50; 32% of women had a poorly differentiated tumor compared with 26% of men. General condition had no correlation with degree of differentiation. Site was closely associated with grading: well-differentiated tumors were more common in the mouth and larynx and poorly differentiated tumors in the pharynx. Furthermore, of poorly differentiated tumors, 19% arose from areas normally lined by keratinized squamous epithelium, 22% from a nonkeratinized area, 36% from respiratory epithelium, and 45% from areas normally covered by lymphoid epithelium. T stage had no significant correlation with differentiation. However, 46% of patients with poorly differentiated tumors had a nodal metastasis at presentation compared with only 28% of well-differentiated tumors. Distant metastases at presentation were found in 3.4% of poorly differentiated tumors compared with 1.8% of well-differentiated tumors. The survival fell significantly from 33% for well-differentiated tumors to 27% for poorly differentiated tumors. The recurrence rate at the primary site rose from 25% for well-differentiated tumors to 27% for poorly differentiated tumors, and recurrence in the lymph nodes rose from 26% to 30%. Both differences were just significant.

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Section: The Criteria Used Have a Subjective Elementmentioning

confidence: 99%

Value of grading squamous cell carcinoma of the head and neck

et al. 1992

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Radiation Therapy for Carcinoma of the Larynx: Observations After Twenty Years

Salinger¹

1940

Archives of Otolaryngology - Head and Neck Surgery

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There are so many aspects to the story of radium as a therapeutic agent in cases of carcinoma of the larynx that I find it difficult to array the items in their logical sequence. And yet it was my purpose in preparing this paper to set forth the evidence as I have found it in twenty years' observation, hoping thereby to crystallize such conclusions as mature deliberation might evolve. It is not an easy task, because the mystery and glamour which surrounded this element from the time of its discovery still seem to captivate the imagination of both physicians and the public to a degree that is incompatible with the exercise of cool judgment. The hope which it inspired in the human breast, that at last the dreadful scourge of cancer was to be lifted through this powerful agent, was too thrilling to be easily abandoned or even modified by sober experience. Much of this feeling, I believe, may be attributed to the attitude of the press, which always seeks to capitalize the sensational. Startling headlines and incomplete quotations of responsible physicians in connection with the hopes and promises of radiation therapy have done much to foster an optimism which is out of proportion to accom¬ plished facts. The mere account of the establishment of a new cancer clinic, stressing the high cost of the radium or the magnitude of the high voltage machines, must necessarily impress the average layman and lead to the conclusion that such a valuable armamentarium possesses therapeutic merit commensurate with its cost. This is a psychologic phenomenon which is difficult to counteract, since it is natural for the untrained mind to judge values in direct proportion to costs. When with this faith in the potency of a mysterious costly agent (which has in some quarters been exploited) one considers the average resistance to major surgical procedures, especially when they concern a conspicuous organ like the larynx, it is not difficult to appreciate the advantage which this nonsurgical therapy possesses in the layman's mind. And that brings me to the first point which I hope to demonstrate before I have finished,

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Carcinoma of the Larynx: A Review of Treament and End Results at the Brooklyn Cancer Institute

Howes¹,

Platau²

1944

Archives of Otolaryngology - Head and Neck Surgery

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Pathologic Differentiation Between Radiosensitive and Nonradiosensitive Malignant Neoplasms of the Larynx

Cited by 16 publications

References 4 publications

Value of grading squamous cell carcinoma of the head and neck

Value of grading squamous cell carcinoma of the head and neck

Radiation Therapy for Carcinoma of the Larynx: Observations After Twenty Years

Carcinoma of the Larynx: A Review of Treament and End Results at the Brooklyn Cancer Institute

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