Pathologic diagnosis of papillary thyroid carcinoma: today and tomorrow

Baloch, Zubair W.; LiVolsi, Virginia A.

doi:10.1586/14737159.5.4.573

Cited by 36 publications

(23 citation statements)

References 117 publications

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“…Recently, many advances have been made in the pathogenesis of PTC. The genetic events include rearranged during transfection (RET)/PTC rearrangements, RAS and BRAF gene mutations [3]. Some correlations have been described between the subtype of PTC (FVPTC versus classic PTC) and the type of gene mutations [6,14].…”

Section: Discussionmentioning

confidence: 99%

A score based on microscopic criteria proposed for analysis of papillary carcinoma of the thyroid

Verhulst

Devos²,

Aubert

et al. 2008

Virchows Arch

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Morphologic examination is the gold standard for diagnosing papillary thyroid carcinoma (PTC). This diagnosis, especially for the follicular variant, may be variable even among experts. Our objective was to analyze the frequency of PTC microscopic criteria in a series of thyroid tumors including follicular adenoma (FA) and PTC to build a score which could constitute a novel way for microscopic analysis of such thyroid tumors. Sixty-six PTC and 66 FA were matched for age, sex, and thyroiditis. Two independent observers delineated the classical PTC microscopic criteria. PTC microscopic criteria were variably expressed in individual tumors. Under univariate analysis, all criteria were significantly more frequent in PTC than in FA (p<0.05). Under multivariate analysis, the most important criteria were: dark staining colloid >25%, nuclear grooves, enlarged nuclei, ovoid nuclei >5% of tumor cells, and lack of polarization. Using linear discriminant analysis, these five criteria allowed us to build a scaled score. The score proposed did not allow the making of a definite distinction between FA and PTC in routine practice. It represents the variety of microscopic presentations of FA and PTC on the basis of a statistical analysis and could help in further evaluation of immunohistochemical or molecular markers.

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Section: Discussionmentioning

confidence: 99%

A score based on microscopic criteria proposed for analysis of papillary carcinoma of the thyroid

Verhulst

Devos²,

Aubert

et al. 2008

Virchows Arch

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“…Several oncogenes are now being assessed histologically in PTC including p53 and BRAF. BRAF positivity predicts for poor prognosis as well as a higher probability of nodal spread [9].…”

Section: Predictors For Nodal Metastasesmentioning

confidence: 99%

The role of lymphadenectomy in the management of papillary carcinoma of the thyroid

Rotstein¹

2009

Journal of Surgical Oncology

104

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Impact of nodal involvement in papillary thyroid cancer remains controversial. The incidence of nodal metastases is high and the presence of involved nodes has a negative impact on recurrence and possibly on survival as well, particularly in older patients. The risk of nodal disease increases with age, tumor size, and BRAF oncogene expression. Most thyroid surgeons sample the ipsilateral central nodes as a minimum and clear the central compartment if there is gross adenopathy present. Lateral compartment neck dissection is reserved for patients with known metastatic disease. This article attempts to review the literature on surgery of lymph nodes in papillary thyroid cancer.

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“…7 3) Fibrosing thyroiditis versus papillary microcarcinoma. 5) Most papillary carcinoma of thyroid can be diagnosed with ease by utilizing morphological criteria, except cases in which there is a paucity of diagnostic nuclear features 10,11 such as in cystic variant of papillary carcinoma. This variant exhibits large edematous papillary structures lined by cells having nuclei with dispersed chromatin.…”

Section: Discussionmentioning

confidence: 99%

Role of Alcian blue (pH 2.5) histochemical stain in diagnostic thyroid pathology: how far is it helpful?

Palo

Biligi

2015

Int J Res Med Sci

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Pathologic diagnosis of papillary thyroid carcinoma: today and tomorrow

Cited by 36 publications

References 117 publications

A score based on microscopic criteria proposed for analysis of papillary carcinoma of the thyroid

A score based on microscopic criteria proposed for analysis of papillary carcinoma of the thyroid

The role of lymphadenectomy in the management of papillary carcinoma of the thyroid

Role of Alcian blue (pH 2.5) histochemical stain in diagnostic thyroid pathology: how far is it helpful?

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