Pathologic correlation with near infrared-indocyanine green guided surgery for pediatric liver cancer

Whitlock, Richard S.; Patel, Kalyani R.; Yang, Tianyou; Nguyen, HaiThuy N; Masand, Prakash; Vasudevan, Sanjeev A.

doi:10.1016/j.jpedsurg.2021.04.019

Cited by 25 publications

(31 citation statements)

References 45 publications

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“…To achieve thorough metastasectomy with shorter surgeries and fewer operations, further optimization of the dose of ICG and the timing of its administration may be essential. In two recently published articles, higher specificity (0.57–0.74) has been reported for pulmonary metastasectomy for hepatoblastoma using ICG imaging 26,27 . The dose of ICG used was similar to that in our method.…”

Section: Discussionsupporting

confidence: 68%

“…In two recently published articles, higher specificity (0.57-0.74) has been reported for pulmonary metastasectomy for hepatoblastoma using ICG imaging. 26,27 The dose of ICG used was similar to that in our method. However, the timing of ICG administration was earlier (48-96 h before surgery) in one report.…”

Section: Discussionmentioning

confidence: 99%

“…However, the timing of ICG administration was earlier (48-96 h before surgery) in one report. 26 To minimize the resected lung volume, a wedge-shaped resection with a minimal margin performed with open thoracotomy may be more efficient than linear-stapler thoracoscopic surgery. 10 Having undertaken considerable numbers of metastasectomies Although the sensitivity of ICG imaging is high, several falsenegative (ICG-negative tumor-positive) specimens were identified, suggesting that some metastatic tumors cannot be detected with ICG imaging.…”

Section: Discussionmentioning

confidence: 99%

“…In a series of pulmonary metastasectomies for hepatoblastoma using ICG imaging, metastatic nodules with osteoid or chondroid features produced false-negative results. 26 There may be several reasons why those metastatic nodules were ICG negative. Recognizing the limitations of metastasectomy with ICG imaging is also important.…”

Section: Discussionmentioning

confidence: 99%

“…The dose of ICG used was similar to that in our method. However, the timing of ICG administration was earlier (48–96 h before surgery) in one report 26 . To minimize the resected lung volume, a wedge‐shaped resection with a minimal margin performed with open thoracotomy may be more efficient than linear‐stapler thoracoscopic surgery 10 …”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological study of surgery for pulmonary metastases of hepatoblastoma with indocyanine green fluorescent imaging

Yoshida

Tanaka

Kitagawa

et al. 2021

Pediatric Blood & Cancer

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Background:The prognosis of metastatic hepatoblastoma remains poor; to improve it, pulmonary metastasis must be controlled. Indocyanine green (ICG) fluorescent imaging has been used recently for lung metastasectomy. The objective of our study was to clarify the usefulness of ICG imaging for lung metastasectomy of hepatoblastoma using detailed clinicopathological analysis.Procedure: Patients with hepatoblastoma who underwent resection of pulmonary metastases with ICG fluorescent imaging were studied using a retrospective analysis of clinical information, a review of their surgical records, and a histological analysis of their metastatic nodules.Results: Sixteen patients were enrolled. In total, 61 ICG imaging-guided pulmonary metastasectomies were performed, and 350 ICG-positive and 23 ICG-negative specimens were identified. Tumors were confirmed in 250 of the ICG-positive specimens, including eight nonpalpable nodules, on microscopic examination. ICG-positive and tumor-negative specimens showed histological changes suggesting the regression of a tumor or bloodstream disturbance.Conclusions: Surgical resection is one of the few treatment strategies available to patients with hepatoblastoma with multiple relapses of pulmonary metastasis resistant to chemotherapy. This study demonstrates the high sensitivity of ICG imaging and that thorough metastasectomy can be achieved with ICG imaging. Because a number of false-positive specimens were detected, further optimization of the dose of ICG and the timing of its administration, and establishment of detection of ICG-positive, tumornegative nodules during surgery are important issues. Several false-negative specimens were also detected, suggesting the presence of ICG-negative metastatic tumors. Palpation during surgery and imaging studies remain essential for detecting metastatic lesions, even in the era of ICG imaging.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Clinicopathological study of surgery for pulmonary metastases of hepatoblastoma with indocyanine green fluorescent imaging

Yoshida

Tanaka

Kitagawa

et al. 2021

Pediatric Blood & Cancer

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Recent advances in surgical strategies and liver transplantation for hepatoblastoma

et al. 2022

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Hepatoblastoma (HB) is the most common malignant liver tumor in children.Although the development of treatment strategies with advances in chemotherapy has greatly improved the prognosis of HB, surgical resection and liver transplantation still play a vital role in the treatment of HB. In recent years, technological innovations have led to the development of new surgical approaches for HB. In this review, we describe the latest research on the surgical management of HB, including new imaging technologies, minimally invasive approaches, and the application of associating liver partition portal vein ligation for staged hepatectomy. We also discuss the current role of liver transplantation, use of antesitum or ex-situ liver resection with auto-transplantation, and management of metastatic HB.

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Current trends and prospects of surgical techniques for hepatoblastoma

Pu,

Li,

et al. 2024

Cancer Medicine

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Hepatoblastoma, a common extracranial malignant solid tumor in childhood, is often detected at an advanced stage and is difficult to treat surgically. Despite the availability of multiple comprehensive treatments that can be combined with surgery, hepatoblastoma treatment outcomes remain poor. Surgery is the main treatment strategy for hepatoblastoma, but it faces many challenges, including tumor attachment to surrounding tissues, tumor wrapping or invading of vital organs and tissues, the presence of giant or multiple tumors, distant metastasis, the formation of a tumor thrombus, and significant surgical trauma. In this review, we discuss recent research advances and propose potential strategies for overcoming these challenges. Such strategies may improve the rate of hepatoblastoma resection and local control in children, as well as reduce complications and trauma.

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Pathologic correlation with near infrared-indocyanine green guided surgery for pediatric liver cancer

Cited by 25 publications

References 45 publications

Clinicopathological study of surgery for pulmonary metastases of hepatoblastoma with indocyanine green fluorescent imaging

Clinicopathological study of surgery for pulmonary metastases of hepatoblastoma with indocyanine green fluorescent imaging

Recent advances in surgical strategies and liver transplantation for hepatoblastoma

Current trends and prospects of surgical techniques for hepatoblastoma

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