Pathologic Complete Response and Oncologic Outcomes in Locally Advanced Breast Cancers Treated With Neoadjuvant Radiation Therapy: An Australian Perspective

Lin, Yuan-Hong; Chidley, Phoebe; Admojo, Lorenztino; Jassal, Sunil; Zantuck, N.; Foroudi, Farshad; Bevington, E.; Chew, Grace; Hyett, A.; Loh, Su-Wen; Ng, Suat Li; Leech, Tristan; Baker, Caroline; Law, Michael; Ooi, W; Yong, Charles; Khor, Richard; Chao, Michael

doi:10.1016/j.prro.2022.12.004

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…While concurrent chemoradiotherapy is more common in other cancers, the combination has shown promise in TNBC, particularly in aggressive subtypes. Studies have demonstrated varying degrees of pathological complete response (pCR) rates with preoperative chemo-radiotherapy in TNBC, ranging from 23% to 71% ( 62 ). Toxicity profiles have generally been manageable, with some studies reporting mild to moderate acute toxicity.…”

Section: Therapeutic Strategies For Tnbcmentioning

confidence: 99%

Advancements and challenges in triple-negative breast cancer: a comprehensive review of therapeutic and diagnostic strategies

Xiong,

Wu,

2024

Front. Oncol.

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Triple-negative breast cancer (TNBC) poses significant challenges in oncology due to its aggressive nature, limited treatment options, and poorer prognosis compared to other breast cancer subtypes. This comprehensive review examines the therapeutic and diagnostic landscape of TNBC, highlighting current strategies, emerging therapies, and future directions. Targeted therapies, including PARP inhibitors, immune checkpoint inhibitors, and EGFR inhibitors, hold promise for personalized treatment approaches. Challenges in identifying novel targets, exploring combination therapies, and developing predictive biomarkers must be addressed to optimize targeted therapy in TNBC. Immunotherapy represents a transformative approach in TNBC treatment, yet challenges in biomarker identification, combination strategies, and overcoming resistance persist. Precision medicine approaches offer opportunities for tailored treatment based on tumor biology, but integration of multi-omics data and clinical implementation present challenges requiring innovative solutions. Despite these challenges, ongoing research efforts and collaborative initiatives offer hope for improving outcomes and advancing treatment strategies in TNBC. By addressing the complexities of TNBC biology and developing effective therapeutic approaches, personalized treatments can be realized, ultimately enhancing the lives of TNBC patients. Continued research, clinical trials, and interdisciplinary collaborations are essential for realizing this vision and making meaningful progress in TNBC management.

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Section: Therapeutic Strategies For Tnbcmentioning

confidence: 99%

Advancements and challenges in triple-negative breast cancer: a comprehensive review of therapeutic and diagnostic strategies

Xiong,

Wu,

2024

Front. Oncol.

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“…The rate of postsurgical complications using the Clavien-Dindo classification of surgical complications ( 52 ) was recently published by Lin et al ( 53 ). Following sequential neoadjuvant chemotherapy (NACT) and NART, mastectomy with or without axillary surgery and immediate autologous BR were performed.…”

Section: Basic Concepts In Breast Reconstructionmentioning

confidence: 99%

Technical consideration for breast reconstruction in patients requiring neoadjuvant or adjuvant radiotherapy: a narrative review

Maita,

Torres-Guzman,

Avila

et al. 2023

Ann Transl Med

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Background and Objective Surgical considerations for breast reconstruction (BR) in patients requiring neoadjuvant radiotherapy (NART) or adjuvant radiotherapy (ART) cannot be understated. The management of irradiated tissue leads surgeons to face several challenges. Therefore, it is essential to comprehensively understand the proper patient selection and preoperative planning to ensure the best outcomes and minimize the risk of complications. This narrative review aims to provide an update and summary of the most important technical considerations every breast surgeon must contemplate reconstructing the irradiated breast. Methods The search strategy was performed on January 10th, 2023. The PubMed, Embase, Cochrane Library, and Web of Science databases were queried to capture all publications regarding surgical considerations in BR of patients undergoing NART and ART. Key Content and Findings This review shows that the effects of radiotherapy (RT) on BR are still being studied. RT represents an essential factor for overall patient survival, and its use is increasing. However, the range of RT treatments across different cancer centers complicates the creation of a single treatment protocol. BR improves women’s quality of life, so finding the proper integration of BR and RT is essential. When deciding on the reconstructive method, there are several factors to consider, such as the patient’s body characteristics, tumor stage, RT protocol, and chemotherapy. To achieve the best surgical results and the most satisfied patient, using less aggressive and safer RT methods in the treatment sequence is recommended. Conclusions The timing of the radiation will influence the selection of the best reconstructive methods to be employed in the breast cancer patient. However, there is clear evidence of preference for immediate autologous-based BR in cases due to the low rate of complications in the long term. But patient individualization is the key. Therefore, the benefits and risks of immediate versus delayed and autologous versus implant-based reconstruction must be weighed in every single case.

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Pre-operative chemoradiotherapy followed by mastectomy and breast reconstruction—A systematic review of clinical, oncological, reconstructive and aesthetic outcomes

Ward,

Ho,

Ike

et al. 2024

Journal of Plastic, Reconstructive & Aesthetic Surgery

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Pathologic Complete Response and Oncologic Outcomes in Locally Advanced Breast Cancers Treated With Neoadjuvant Radiation Therapy: An Australian Perspective

Cited by 5 publications

References 38 publications

Advancements and challenges in triple-negative breast cancer: a comprehensive review of therapeutic and diagnostic strategies

Advancements and challenges in triple-negative breast cancer: a comprehensive review of therapeutic and diagnostic strategies

Technical consideration for breast reconstruction in patients requiring neoadjuvant or adjuvant radiotherapy: a narrative review

Pre-operative chemoradiotherapy followed by mastectomy and breast reconstruction—A systematic review of clinical, oncological, reconstructive and aesthetic outcomes

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