Pathologic Characteristics of Bowel Endometriosis

Vellone, Valerio Gaetano; Biatta, Chiara Maria; Paudice, Michele; Barra, Fabio; Ferrero, Simone; Scaglione, Giulia

doi:10.1007/978-3-030-50446-5_3

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Histopathological and Molecular Based Classification: The1

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2021

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“…In 1983, centered on clinic-pathological and molecular genetics features, EC was divided into two main groups: Type I and Type II [ 16 ]. There is a less-than-perfect correlation between histopathological subtypes and pathogenetic types of ECs [ 17 ]. About 80% of all ECs are type I lesions, related to long-lasting unopposed estrogen exposure, especially in pre- and peri-menopausal status.…”

Section: Histopathological and Molecular Based Classification: Thementioning

confidence: 99%

New Insights into Endometrial Cancer

Paleari

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Rutigliani

et al. 2021

Cancers

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EC is the most common cancer in the female genital tract in developed countries, and with its increasing incidence due to risk factors, such as aging and obesity, tends to become a public health issue. Although EC is a hormone-dependent neoplasm, there are no recommendations for the determination of steroid hormone receptors in the tumor tissue and no hormone therapy has ever been assessed in the adjuvant setting. Furthermore, its immune environment has been slightly characterized, but recent evidences point out how EC microenvironment may increase self-tolerance by reducing the recruitment of cytotoxic immune cells to the tumor site and/or modifying their phenotype, making these cells no longer able to suppress tumor growth. Here we highlight insights for EC management from diagnosis to a desirable trend of personalized treatment.

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Section: Histopathological and Molecular Based Classification: Thementioning

confidence: 99%