Pathologic changes in the cardiac interstitium of mice infected with encephalomyocarditis virus

Neumann, David; Wulff, Scott M.; Leppo, Michelle K.; Love, Lori A.; Rose, Noel R.; Herskowitz, Ahvie

doi:10.1016/1054-8807(93)90023-u

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…The extracellular matrix was thought to serve as a relatively inert frame to stabilize the physical structure of myocytes. But it is now clear that the matrix plays an active role in regulating the behaviour of the cells in myocarditis and other myocardial diseases (Zhao et al 1988;Pick et al 1989;Frizelle et al 1992;Gomez et al 1992;Villareal & Dillmann 1992;Neumann et al 1993;Hinglais et al 1994).…”

Section: Discussionmentioning

confidence: 99%

Interstitial fibrin‐fibronectin deposition with T cell infiltrates precedes fibrosis in murine viral myocarditis

Kishimoto¹,

Kitazawa

Takada³

1998

Int J Experimental Path

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This study was carried out to investigate interstitial fibrin and fibronectin deposition and subsequent myocardial connective tissue abnormalities in BALB/c-nu/+ (euthymic and normal T cell function) and BALB/c-nu/nu (athymic and T cell-deficient) mice. Both types of mice were inoculated with encephalomyocarditis virus and sacrificed periodically. Sections of the hearts were stained with haematoxylin-eosin, trichrome, lymphocyte subsets, silver impregnation, and fibrin or fibronectin. In addition, myocardial collagen concentration was measured. Interstitial fibrin and fibronectin appeared in parallel with inflammatory T lymphocytes and myocardial necrosis in the BALB/c-nu/+ mice. The changes increased until 14 days, subsequently decreasing with time. Interstitial fibrosis and abnormal reticulin fibres were absent until 7 days postinfection, and then increased with time until 60 days. In BALB/c-nu/nu mice, in contrast, although myocardial necrosis and fibrin-fibronectin deposition associated with immature T lymphocytes were evident on days 7 and 14, subsequent myocardial fibrosis and reticulin fibre abnormalities were minimal on days 30 and 60. In BALB/c-nu/+ mice, myocardial collagen concentration increased on day 30, but it did not in BALB/c-nu/nu mice. Thus, interstitial fibrin-fibronectin deposition resulting from virus-induced and T lymphocyte-mediated myocyte necrosis precedes the subsequent development of interstitial fibrosis and abnormal reticulin architectures in this model of murine myocarditis.

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Section: Discussionmentioning

confidence: 99%