Pathologic Changes Associated with the Use of Sodium Ethylene Diamine Tetra-Acetate in the Treatment of Hypercalcemia

Treatment of Lead-poisoning with Oral Penicillamine

“…was first used 10 years ago for the treatment of lead-poisoning; when given intravenously it induces a marked urinary excretion of lead. There are obvious disadvantages in the use of a parenteral preparation, especially in children, and renal damage has been reported after excessive dosage (Dudley et al, 1955;Foreman et al, 1956). An effective oral non-toxic lead chelator would be of considerable value in the treatment and possibly in the prophylaxis (Seignette et al, 1959) of lead-poisoning.…”

Penicillamine as Lead-chelating Substance in Man

“…were published (Belknap, 1952;Bessman et al, 1952;Karpinski et al, 1953;Ohlsson, 1954;Rieders et al, 1955;Sidbury, 1955;Glomme and Swensson, 1956). But this substance also gave rise to disappointments; for several cases of renal damage, some of them fatal, occurred after excessive dosage (Dudley et al, 1955;Foreman et al, 1956;Moeschlin, 1957).…”

Drugs for the treatment of hypercalcaemia

“…The appropriate compleximetric titration methods for calcium estimation are not widely available. In addition there have been reports (Dudley et al, 1955) of renal damage after EDTA therapy and this treatment has fallen into disuse.…”