Pathologic aspects of skull base tumors

Marszałek, Andrzej; Szylberg, Łukasz; Wiśniewski, S.

doi:10.1016/j.rpor.2016.02.006

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…The World Health Organization (WHO) classifies them as grade I tumors due to their lack of histological signs of malignancy [3], although malignant transformation has been reported in rare cases [4]. Histologically, there are two main CP subtypes, namely, adamantinomatous and papillary, which differ in age distribution, frequency, biology, and clinical outcome [2,[5][6][7]. Adamantinomatous CP predominantly affects subjects younger than 14 years of age and is, therefore, considered the "pediatric" type, accounting for 5-10% of central nervous system (CNS) tumors in this age group [5,7].…”

Section: Introductionmentioning

confidence: 99%

“…Histologically, there are two main CP subtypes, namely, adamantinomatous and papillary, which differ in age distribution, frequency, biology, and clinical outcome [2,[5][6][7]. Adamantinomatous CP predominantly affects subjects younger than 14 years of age and is, therefore, considered the "pediatric" type, accounting for 5-10% of central nervous system (CNS) tumors in this age group [5,7].…”

Section: Introductionmentioning

confidence: 99%

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Predictive Factors for Pediatric Craniopharyngioma Recurrence: An Extensive Narrative Review

et al. 2023

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Despite being classified as benign tumors, craniopharyngiomas (CPs) are associated with significant morbidity and mortality due to their location, growth pattern, and tendency to recur. Two types can be identified depending on age distribution, morphology, and growth pattern, adamantinomatous and papillary. The adamantinomatous CP is one of the most frequently encountered central nervous system tumors in childhood. Our aim was to review the relevant literature to identify clinical, morphological, and immunohistochemical prognostic factors that have been implicated in childhood-onset CP recurrence. Lack of radical surgical removal of the primary tumor by an experienced neurosurgical team and radiotherapy after a subtotal excision has been proven to significantly increase the recurrence rate of CP. Other risk factors that have been consistently recognized in the literature include younger age at diagnosis (especially <5 years), larger tumor size at presentation, cystic appearance, difficult tumor location, and tight adherence to surrounding structures, as well as the histological presence of whorl-like arrays. In addition, several other risk factors have been studied, albeit with conflicting results, especially in the pediatric population. Identifying risk factors for CP recurrence is of utmost importance for the successful management of these patients in order to ultimately ensure the best prognosis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Predictive Factors for Pediatric Craniopharyngioma Recurrence: An Extensive Narrative Review

et al. 2023

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“…The treatment and the prognosis may dramatically change in the case of a benign lesion without compression of critical structures or a malignant tumour invading and infiltrating nervous tissue in the brainstem or in the temporal lobes. A comprehensive review of the main tumour types arising in the skull base is reported by Marszalek et al 3 who describe the main pathologic features of these tumours. The correct histological diagnosis is the first step for planning the subsequent imaging staging and discuss possible treatment approaches.…”

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confidence: 99%