Pathogens Isolated From Deep Soft Tissue and Bone in Patients With Diabetic Foot Infections

Ertuğrul, Mustafa Bülent; Baktiroğlu, Selçuk; Salman, Serpil; Ünal, Sabri; Aksoy, Murat; Berberoğlu, Kezban; Çalangu, Semra

doi:10.7547/0980290

Cited by 38 publications

(27 citation statements)

References 27 publications

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“…Kemik Biyopsisi: Kemik biyopsisi var olan tanı yöntem-leri içinde kemik infeksiyonunun histopatolojik tanısında olduğu kadar, infeksiyon etkeninin ve antibiyotik duyarlılığı-nın saptanmasında ve tedavinin belirlenmesinde en geçerli yöntemdir (45)(46)(47). Kemik dokusunun kültüründe üreme olmasının, osteomyelit tanısında yüksek bir duyarlılık (%92) ve özgüllüğe (%60) sahip olduğu gösterilmiştir (48).…”

Section: Soru 2: Osteomyelit Tanısında Hangi Laboratuvar Bulguları Yaunclassified

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Diagnosis, Treatment and Prevention of Diabetic Foot Wounds and Infections: Turkish Consensus Report

Saltoğlu¹,

Kılıçoğlu²,

Baktiroğlu³

et al. 2016

Klimik Dergisi

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Study Group for Diabetic Foot Infections of the Turkish Society of Clinical Microbiology and Infectious Diseases has called for collaboration of the relevant specialist societies and the Ministry of Health to issue a national consensus report on the diagnosis, treatment and prevention of diabetic foot (DF) wounds and diabetic foot infections (DFIs) in Turkey. In the periodical meetings of the assigned representatives from all the parties, various questions as to pathogenesis, microbiology, assessment and grading, treatment, prevention and control of diabetic foot were identified. Upon reviewing related literature and international guidelines, these questions were provided

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Section: Soru 2: Osteomyelit Tanısında Hangi Laboratuvar Bulguları Yaunclassified

“…Alınacak örnekler perkütan biyopsi ya da açık cerrahi yön-temle alınmalıdır (49). Kemikteki patojenlerin saptanmasında yumuşak doku veya sinüs ağzından alınan örnekler yeterli değildir (45,50). Osteomyelit tanısında altın standard her zaman histopatolojik incelemedir (33,51).…”

Section: Soru 2: Osteomyelit Tanısında Hangi Laboratuvar Bulguları Yaunclassified

Diagnosis, Treatment and Prevention of Diabetic Foot Wounds and Infections: Turkish Consensus Report

Saltoğlu¹,

Kılıçoğlu²,

Baktiroğlu³

et al. 2016

Klimik Dergisi

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“…Since publication of the previous DFI guidelines, many studies have demonstrated the increasing role of MRSA in DFI [121,[126][127][128][129]. Whereas some studies document MRSA in almost one-third of DFIs [86,127], others report rates of little more than 10% in complicated skin infections and DFIs [118,120,130].…”

Section: Evidence Summarymentioning

confidence: 99%

“…Most recent studies of complicated skin and skin structure (including diabetic foot) infections in developed (especially northern) countries have reported that P. aeruginosa is isolated in <10% of wounds [117,118]. Furthermore, even when isolated, patients often improve despite therapy with antibiotics ineffective against P. aeruginosa [79,90,[119][120][121]. Conversely, in countries where P. aeruginosa is a frequent isolate [122][123][124], or in patients who have been soaking their feet, who have failed therapy with nonpseudomonal therapy, or who have a severe infection, empiric antipseudomonal therapy may be advisable.…”

Section: Evidence Summarymentioning

confidence: 99%

Risk Factors of Methicillin-Resistant Staphylococcus Aureus and Pseudomonas Infection in Diabetic Foot Ulcers in Korea

Lee

Son

Han

2017

J Wound Management Res

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“…The most frequently isolated agents are gram positive cocci such as Staphylococcus aureus in superficial infections of mild to moderate severity in acute phases; Polymicrobial infections, in which gram negative bacilli and anaerobic bacteria are effective concomitantly, in addition to gram positive cocci in advanced stages and in the presence of severe infection [1,3,7,8]. The most reliable method to detect the causative agent is obtaining a culture; however, when this is not possible, culturing the aspiration material from the pus provides more reliable results compared to swab samples [9,10].…”

Section: Introductionmentioning

confidence: 99%

Diabetic foot infections: effective microorganisms and factors affecting the frequency of osteomyelitis and amputation

Sönmezer¹,

Tülek²,

Ozsoy³

et al. 2015

Eur Res J

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Diabetic foot infection is one of the complications of diabetes; it has high mortality and morbidity and is also one of the most common causes of hospitalization in diabetes [1,2]. Diabetic foot infections generally start as a soft tissue infection secondary to a minor trauma, may advance to osteomyelitis, and eventually become a risk factor for amputation [3,4]. Approximately one-fourth of ABSTRACT 119Objectives. Diabetic foot infections are common reason for hospitalization and are associated with high morbidity and mortality. We aimed to evaluate the clinic features and predisposed causes of osteomyelitis and amputation of patients with diabetic foot infections. Methods. Patients with diabetic foot infections who admitted and hospitalized at Infection Diseases and Clinical Microbiology department between January 2012 and July 2014 were included. Osteomyelitis was evaluated using magnetic resonance imaging (MRI) or bone scintigraphy. Microbiological examinations (Gram staining and culture) of the debridement materials and pus aspiration materials of the lesions were performed. Results. Of the seventy-three diabetic foot infected patients, 37 (50.7%) were female, and 36 (49.3%) were male. The mean age of patients was 57±9.8 years. The mean duration of diabetes and HbA1c level were 13.3±5.3 years and 8.17±1.83%; respectively. Soft tissue infection without osteomyelitis was present in only 34 out of 73 (46.5%) patients. A total of 89 pathogens were identified in 52 patients whereas any microorganism was not identified in 28.7%. Polymicrobial infections were detected in 30 (41%) patients. The most common isolated microorganism was Pseudomonas aeruginosa (36.9%), followed by Staphylococcus aureus (31.5%) and Enterococcus spp. (13.6%). Of the 37 (50.7%) patients had a history of diabetic foot infection previously, osteomyelitis progression was higher (89.2%) and statistically significant in these patients. Twelve (16.4%) patients underwent amputation. Conclusions. Advanced age and presence of osteomyelitis were found as risk factors for amputation. In the presence of osteomyelitis, treatment of diabetic foot infections is difficult and amputation rate is higher. For this reason, diabetic foot infections should be promptly treated before the development of osteomyelitis, and multidisciplinary approach is needed.

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Pathogens Isolated From Deep Soft Tissue and Bone in Patients With Diabetic Foot Infections

Abstract: Culture specimens should be obtained from both the bone and the overlying deep soft tissue in patients with suspected osteomyelitis whose clinical conditions are suitable. The decision to administer antibiotic therapy should depend on these results.

Cited by 38 publications

References 27 publications

Diagnosis, Treatment and Prevention of Diabetic Foot Wounds and Infections: Turkish Consensus Report

Diagnosis, Treatment and Prevention of Diabetic Foot Wounds and Infections: Turkish Consensus Report

Risk Factors of Methicillin-Resistant Staphylococcus Aureus and Pseudomonas Infection in Diabetic Foot Ulcers in Korea

Diabetic foot infections: effective microorganisms and factors affecting the frequency of osteomyelitis and amputation

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