Pathogens in ticks collected from dogs in Berlin/Brandenburg, Germany

Schreiber, Cécile; Krücken, Jürgen; Beck, Stephanie; Maaz, Denny; Pachnicke, Stefan; Krieger, Klemens J.; Groß, Marcus; Kohn, Barbara; Samson‐Himmelstjerna, Georg von

doi:10.1186/preaccept-1653925552127672

Cited by 15 publications

(23 citation statements)

References 39 publications

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“…The present case of 'Candidatus Neoehrlichia mikurensis' infection was noted in a dog with renal Fanconi syndrome. Interestingly, 'Candidatus Neoehrlichia mikurensis' was detected in the kidneys of a Croatian dog; however, this dog presented with a severe hemolytic anemia and the authors did not mention any signs of kidney disease (Beck et al, 2014). We speculated that local colonization of the kidneys with the infectious agent in our dog could have resulted in damage of the renal tubular system and consequently the observed glucosuria and hyperaminoaciduria, which were described as renal Fanconi syndrome.…”

Section: Discussionmentioning

confidence: 86%

“…After therapy with doxycycline the dog had recovered uneventfully (Diniz et al, 2011). 'Candidatus Neoehrlichia mikurensis' DNA was also found in paraffin-embedded kidney tissue of a 3.5 month old Croatian dog who died from hemolytic anemia (Beck et al, 2014) and most recently, a Candidatus Neoehrlichia sp. was detected in a red fox from Austria (Hodzic et al, 2015).…”

Section: Introductionmentioning

confidence: 97%

“…In Switzerland, the prevalence of 'Candidatus Neoehrlichia mikurensis' in I. ricinus was estimated to be 6.4% in the western region and 3.5-8% in the eastern region of the country (Lommano et al, 2012;Maurer et al, 2013). The bacterium has also been detected in ticks in other European countries, including Germany, the Netherlands and Austria and pathogen specific DNA was detected in ticks collected from Danish and German dogs (Schreiber et al, 2014;Stensvold et al, 2015). Rodents may serve as a reservoir for 'Candidatus Neoehrlichia mikurensis'.…”

Section: Introductionmentioning

confidence: 99%

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Detection of ‘Candidatus Neoehrlichia mikurensis’ and other Anaplasmataceae and Rickettsiaceae in Canidae in Switzerland and Mediterranean countries

Hofmann‐Lehmann

Wagmann

Meli

et al. 2016

SAT

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Detection of ‘Candidatus Neoehrlichia mikurensis’ and other Anaplasmataceae and Rickettsiaceae in Canidae in Switzerland and Mediterranean countries

Hofmann‐Lehmann

Wagmann

Meli

et al. 2016

SAT

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“…(Diniz et al 2009), Rickettsia spp., (small) Babesia spp. (Appel et al 1993;Skotarczak 2014) or Candidatus Neoehrlichia mikurensis (Diniz et al 2011;Schreiber et al 2014; see Table 1), might play a role. In particular, co-infections (by different strains or species) are probably one of the least experimentally investigated areas to date, as is the (immunological) influence of repeated infections over a longer period of time.…”

Section: Borrelia Vaccinationmentioning

confidence: 97%

“…strains (e.g. also B. miyamotoi; Schreiber et al 2014) with a different plasmid content and virulence (Hanincova et al 2013) are additional preconditions. For example, the risk of infection with Borrelia spp.…”

Section: Borrelia Vaccinationmentioning

confidence: 99%

Tick-borne Diseases (Borreliosis, Anaplasmosis, Babesiosis) in German and Austrian Dogs: Status quo and Review of Distribution, Transmission, Clinical Findings, Diagnostics and Prophylaxis

et al. 2015

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Tick-borne diseases (TBD) in dogs have gained in significance in German and Austrian veterinary practices. The widespread European tick species Ixodes ricinus represents an important vector for spirochaetes of the Borrelia burgdorferi sensu lato group and Rickettsiales such as Anaplasma phagocytophilum. The meadow or ornate dog tick (Dermacentor reticulatus) is an important vector for Babesia canis, as is the brown dog tick (Rhipicephalus sanguineus) for Babesia vogeli in the Mediterranean region. The present work covers pathogen transmission by tick vectors, including the mechanisms and the minimum intervals required, in conjunction with possible non-vector-borne transmission routes. It also addresses the incubation periods, pathogenicity and clinical findings associated with each pathogen and genospecies and presents case examples. Current data on prevalence, annual fluctuations and distribution in various pre-selected dog populations (symptomatic versus asymptomatic) in both countries are depicted in maps. Reasons for changes in prevalence (especially of Borrelia) are discussed. Criteria and algorithms for clinical diagnosis and monitoring in dogs, including case history, direct detection (blood smears, molecular detection by species-specific PCR and sequencing) and indirect methods (whole-cell and peptide-based antibody tests), are presented, together with laboratory abnormalities (haematology, clinical chemistry, urine). The role of anti-C6 antibody concentration (ACAC) and its correlation with proteinuria and Lyme nephritis are assessed on the basis of new data. Consideration is also given to the importance of blood smears, PCR and serology in the case of anaplasmosis and babesiosis, and the diagnostic value of combining these methods. The relevance of molecular differentiation of Anaplasma species (A. phagocytophilum versus A. platys) and Babesia spp. (large versus small forms) in cases of serological cross-reaction is emphasized. A summary is given of methods for prophylaxis using acaricide products (collars, spot-on solutions and oral treatments in both countries), vaccination (Borrelia and Babesia vaccines) and imidocarb-based chemoprophylaxis for large Babesia.

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Prevention of transmission of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum by Ixodes spp. ticks to dogs treated with the Seresto® collar (imidacloprid 10% + flumethrin 4.5%)

et al. 2019

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The capability of imidacloprid 10% + flumethrin 4.5% (Seresto®) collars to prevent transmission of Borrelia burgdorferi sensu lato (Bbsl) and Anaplasma phagocytophilum (Ap) by naturally infected ticks was evaluated in two studies with 44 dogs. In each study, one group served as non-treated control, whereas the other groups were treated with the Seresto® collar. All dogs were exposed to naturally Bbsland Ap-infected hard ticks (Ixodes ricinus, Ixodes scapularis). In study 1, tick infestation was performed on study day (SD) 63 (2 months post-treatment [p.t.]); in study 2, it was performed on SD 32 (one month p.t.) respectively SD 219 (seven months p.t.). In situ tick counts were performed 2 days after infestation. Tick counts and removals followed 6 (study 1) or 5 days (study 2) later. Blood sampling was performed for the detection of specific Bbsl and Ap antibodies and, in study 1, for the documentation of Ap DNA by PCR. Skin biopsies were examined for Bbsl by PCR and culture (only study 1). The efficacy against Ixodes spp. was 100% at all time points. In study 1, two of six non-treated dogs became infected with Bbsl, and four of six tested positive for Ap; none of the treated dogs tested positive for Bbsl or Ap. In study 2, ten of ten non-treated dogs became infected with Bbsl and Ap; none of the treated dogs tested positive for Bbsl or Ap; 100% acaricidal efficacy was shown in both studies. Transmission of Bbsl and Ap was successfully blocked for up to 7 months.

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Pathogens in ticks collected from dogs in Berlin/Brandenburg, Germany

Abstract: Frequencies of potential human or canine pathogens in ticks were considerable and DNA of all four groups of pathogens was detected. Differences in scutal indices might suggest that pathogens are frequently taken up by ticks when feeding on dogs in Berlin/Brandenburg.

Cited by 15 publications

References 39 publications

Detection of ‘Candidatus Neoehrlichia mikurensis’ and other Anaplasmataceae and Rickettsiaceae in Canidae in Switzerland and Mediterranean countries

Detection of ‘Candidatus Neoehrlichia mikurensis’ and other Anaplasmataceae and Rickettsiaceae in Canidae in Switzerland and Mediterranean countries

Tick-borne Diseases (Borreliosis, Anaplasmosis, Babesiosis) in German and Austrian Dogs: Status quo and Review of Distribution, Transmission, Clinical Findings, Diagnostics and Prophylaxis

Prevention of transmission of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum by Ixodes spp. ticks to dogs treated with the Seresto® collar (imidacloprid 10% + flumethrin 4.5%)

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