Pathogenicity of Type I Interferons in Mycobacterium tuberculosis

Mundra, Akaash; Yegiazaryan, Aram; Karsian, Haig; Alsaigh, Dijla; Bonavida, Victor; Frame, Mitchell; May, Nicole; Gargaloyan, Areg; Abnousian, Arbi; Venketaraman, Vishwanath

doi:10.3390/ijms24043919

Cited by 11 publications

(9 citation statements)

References 152 publications

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“…However, the effects of IFN-I on the outcome of different infections are very complex, with both protective and detriment effects according to type of micro-organism and types of IFNs involved [ 61 ]. One of most representative examples is MT infection, for which IFN-I signaling demonstrated both pathogenic and protective roles [ 62 ].…”

Section: Role Of Ifns and Anti-ifn Aabs In Infectious Diseasesmentioning

confidence: 99%

Autoantibodies to Interferons in Infectious Diseases

Quiros-Roldan

Sottini

Signorini

et al. 2023

Viruses

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Anti-cytokine autoantibodies and, in particular, anti-type I interferons are increasingly described in association with immunodeficient, autoimmune, and immune-dysregulated conditions. Their presence in otherwise healthy individuals may result in a phenotype characterized by a predisposition to infections with several agents. For instance, anti-type I interferon autoantibodies are implicated in Coronavirus Disease 19 (COVID-19) pathogenesis and found preferentially in patients with critical disease. However, autoantibodies were also described in the serum of patients with viral, bacterial, and fungal infections not associated with COVID-19. In this review, we provide an overview of anti-cytokine autoantibodies identified to date and their clinical associations; we also discuss whether they can act as enemies or friends, i.e., are capable of acting in a beneficial or harmful way, and if they may be linked to gender or immunosenescence. Understanding the mechanisms underlying the production of autoantibodies could improve the approach to treating some infections, focusing not only on pathogens, but also on the possibility of a low degree of autoimmunity in patients.

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Section: Role Of Ifns and Anti-ifn Aabs In Infectious Diseasesmentioning

confidence: 99%

Autoantibodies to Interferons in Infectious Diseases

Quiros-Roldan

Sottini

Signorini

et al. 2023

Viruses

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“…The role of type I interferons during M.tb infection is not completely understood, with some studies reporting a host protective role vs. other studies suggesting a detrimental role under different host- M.tb encounter settings ( 138 , 139 ). However, type I interferons including IFN-α are an important component of the innate immune response to SARS-CoV-2 ( 100 ), and they are rapidly induced in early stages of the infection ( 140 ).…”

Section: Autoimmunitymentioning

confidence: 99%

Tuberculosis and COVID-19 in the elderly: factors driving a higher burden of disease

Allué-Guardia,

Torrelles,

Sigal

2023

Front. Immunol.

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Mycobacterium tuberculosis (M.tb) and SARS-CoV-2 are both infections that can lead to severe disease in the lower lung. However, these two infections are caused by very different pathogens (Mycobacterium vs. virus), they have different mechanisms of pathogenesis and immune response, and differ in how long the infection lasts. Despite the differences, SARS-CoV-2 and M.tb share a common feature, which is also frequently observed in other respiratory infections: the burden of disease in the elderly is greater. Here, we discuss possible reasons for the higher burden in older adults, including the effect of co-morbidities, deterioration of the lung environment, auto-immunity, and a reduced antibody response. While the answer is likely to be multifactorial, understanding the main drivers across different infections may allow us to design broader interventions that increase the health-span of older people.

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“…In his pioneering experiments Robert Koch used guinea pigs and rabbits to prove that a pure Mtb culture causes the disease (13). In the 1950s their susceptibility to TB prompted scientists to use guinea pigs as living air samplers to demonstrate aerial dissemination of mycobacteria (139). They not only take up mycobacteria by inhalation, but also expectorate them like humans and thus are amenable to transmission studies.…”

Section: The Guinea Pig Model For Tbmentioning

confidence: 99%

“…Macrophages containing Mtb then migrate from the air space to the lung interstitium in an IL1-R signaling-and ESX-1 secretion system-dependent manner (138,139). This is the first step preceding the formation of the granuloma, the pathologic hallmark of TB (Figure 2).…”

Section: Tuberculosis and Cell Tropism And Entry Mechanismsmentioning

confidence: 99%

The Covid-19 and TB Syndemic: Differences and Similarities

H. E. Kaufmann,

Sher,

Sigal

et al. 2023

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Pathogenicity of Type I Interferons in Mycobacterium tuberculosis

Cited by 11 publications

References 152 publications

Autoantibodies to Interferons in Infectious Diseases

Autoantibodies to Interferons in Infectious Diseases

Tuberculosis and COVID-19 in the elderly: factors driving a higher burden of disease

The Covid-19 and TB Syndemic: Differences and Similarities

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