Pathogenicity of phospholipase B1 of Trichosporon asahii in immunosuppressed mice

Abstract

Trichosporon asahii is an opportunistic pathogenic yeast-like fungus that colonises the human gastrointestinal tract, respiratory mucosa and skin. 1 T. asahii can cause local infection and systemic disseminated infection. Although immunocompetent individuals can have trichosporemia, 2 invasive trichosporidiosis often occurs in immunocompromised patients with conditions such as severe neutropenia, organ transplantation, malignant tumours, AIDS and other conditions. The mortality of invasive trichosporidiosis can reach 80%. 3 Trichosporonosis treatment is mainly based on antifungal agents, but it exhibits limited sensitivity to antifungal agents apart from azoles. 4

Trichosporon asahii PLA2 Gene Enhances Drug Resistance to Azoles by Improving Drug Efflux and Biofilm Formation

“…Trichosporon asahii, a widely distributed basidiomycete yeast [1], is a common and important clinical pathogen [2]. The mortality rate of deep fungal disease caused by T. asahii is twice that of Candida albicans [3], and this fungus is not sensitive to most antifungal drugs.…”