1994
DOI: 10.1016/s0923-2494(94)80073-1
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Pathogenicity of neutralization escape mutants of mouse hepatitis virus : correlation with T- and B-cell depletions

Abstract: Viral pathogenicity is a result of an imbalance between viral replication and the host's immune defences. When the virus is lymphotropic, understanding the pathogenic process of the viral disease becomes complicated because virus/lymphocyte interactions can alter the cell's integrity and subsequently induce immunodeficiency. The immune system plays an important role in the outcome of acute disease induced by the mouse hepatitis virus type 3 (MHV3). The use of attenuated escape mutants provides a tool to study … Show more

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Cited by 1 publication
(6 citation statements)
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References 38 publications
(28 reference statements)
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“…The livers from YAC-MHV3-infected mice exhibited normal colour and texture. Macroscopic observations were consistent with previous pathological features of the liver from mice infected with these variants, as reported previously [23,25,26].…”
Section: Pathology Induced By the Pathogenicity Variants Of Mhv3 In Ssupporting
confidence: 91%
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“…The livers from YAC-MHV3-infected mice exhibited normal colour and texture. Macroscopic observations were consistent with previous pathological features of the liver from mice infected with these variants, as reported previously [23,25,26].…”
Section: Pathology Induced By the Pathogenicity Variants Of Mhv3 In Ssupporting
confidence: 91%
“…We have demonstrated previously that viral replication cannot explain the levels of hepatitis, as similar viral titres were found in livers from mice infected with pathogenic L2‐MHV3, low attenuated 51·6‐MHV3, highly attenuated CL12‐MHV3 or non‐pathogenic YAC‐MHV3 viruses [26,27]. Viral pathogenicity correlates more with the time of appearance of virus titres in liver than the level of viral titres [26]. These observations support the hypothesis that the pathogenicity of the viral variants reflects their ability to trigger the inflammatory response rather than their capacity to replicate.…”
Section: Discussionmentioning
confidence: 89%
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