Pathogenicity of Life-Shortening
 Wolbachia
 in
 Aedes albopictus
 after Transfer from
 Drosophila melanogaster

Suh, Eunho; Mercer, David R.; Fu, Yuqing; Dobson, Stephen L.

doi:10.1128/aem.01331-09

Cited by 69 publications

(60 citation statements)

References 42 publications

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“…Fig. 1 [online only]), consistent with the previously reported absence of wMelPop paternal inheritance (Hoffmann and Turelli 1988, McGraw et al 2001, Suh et al 2009). …”

Section: Embryonic Microinjection and Maternal Inheritancesupporting

confidence: 80%

“…The level of CI induced by the triple infection was similar to that of the single wMelPop infection in Ae. albopictus, which showed a 77% reduction in egg hatch (i.e., imperfect CI), relative to compatible crosses (Suh et al 2009). The egg hatch resulting from compatible crosses of YFU females was lower than that resulting from compatible IH crosses, suggesting a fitness cost associated with the triple infection, relative to the natural infection.…”

Section: Discussionmentioning

confidence: 99%

“…When provided with mouse blood, the triple infection with wMelPop is best described as "pathogenic," with reduced maternal inheritance and low fecundity (i.e., clutch size and egg hatch), which is consistent with a prior example of a single wMelPop infection in Ae. albopictus (Suh et al 2009). In contrast, when fed with human blood, the wMelPop infection is relatively commensal, i.e., relatively little effect on egg number (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Relative to the wMel Wolbachia type, the wMelPop infections are predicted to strongly reduce pathogen transmission because of a higher degree of pathogen inhibition (Chrostek et al 2013, Ferguson et al 2015. Furthermore, the wMelPop type shows a stronger life-shortening phenotype in adults (McMeniman et al 2009, Suh et al 2009, Yeap et al 2011 and egg stages (i.e., reduced egg longevity; McMeniman and O'Neill 2010, Yeap et al 2011). …”

mentioning

confidence: 99%

“…Particularly, introduction of wMelPop into aposymbiotic Ae. albopictus resulted in pathogenic Wolbachia infection (Suh et al 2009), indicating wMelPop may not be useful for a population replacement strategy, because the associated fitness costs impair Wolbachia invasion. However, a recent study revealed that reductions in egg hatch and clutch size associated with wMelPop infection in Ae.…”

mentioning

confidence: 99%

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Interaction ofWolbachiaand Bloodmeal Type in Artificially InfectedAedes albopictus(Diptera: Culicidae)

Suh

Mercer

et al. 2016

J Med Entomol

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Maternally inherited Wolbachia bacteria are being introduced into vector mosquito populations, with the goal of reducing the transmission of diseases such as dengue fever. The infection dynamics of Wolbachia depends upon the ability of Wolbachia to manipulate host reproduction as well as any fitness costs imposed upon the host. Some vector mosquito species are opportunistic blood feeders, utilizing both human and nonhuman vertebrate hosts, and the effects of bloodmeal source on Wolbachia phenotype is not well understood. Here we transfer wMelPop Wolbachia from Drosophila melanogaster (Meigen) into wild-type Aedes albopictus (Skuse) and characterize the resulting triple infection by examining for an effect of human and mouse blood on the Wolbachia infection persistence and phenotypes. When provided with human blood, the triple Wolbachia infection was persistent, with high maternal inheritance and relatively little fecundity cost, and a pattern of imperfect unidirectional cytoplasmic incompatibility was observed in mating experiments between wild-type and triply infected individuals. With mouse blood, reduced female fecundity and low maternal inheritance were observed in wMelPop-infected females, which affected the typical pattern of unidirectional CI. Our findings indicate the interactive effects of Wolbachia infection and blood source drive distinct shifts in the Wolbachia-host symbiotic association.

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“…Fig. 1 [online only]), consistent with the previously reported absence of wMelPop paternal inheritance (Hoffmann and Turelli 1988, McGraw et al 2001, Suh et al 2009). …”

Section: Embryonic Microinjection and Maternal Inheritancesupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Interaction ofWolbachiaand Bloodmeal Type in Artificially InfectedAedes albopictus(Diptera: Culicidae)

Suh

Mercer

et al. 2016

J Med Entomol

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An elusive endosymbiont: DoesWolbachiaoccur naturally inAedes aegypti?

Ross

Callahan

Yang

et al. 2020

Ecology and Evolution

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Wolbachia are maternally inherited endosymbiotic bacteria found within many insect species. Aedes mosquitoes experimentally infected with Wolbachia are being released into the field for Aedes‐borne disease control. These Wolbachia infections induce cytoplasmic incompatibility which is used to suppress populations through incompatible matings or replace populations through the reproductive advantage provided by this mechanism. However, the presence of naturally occurring Wolbachia in target populations could interfere with both population replacement and suppression programs depending on the compatibility patterns between strains. Aedes aegypti were thought to not harbor Wolbachia naturally but several recent studies have detected Wolbachia in natural populations of this mosquito. We therefore review the evidence for natural Wolbachia infections in A. aegypti to date and discuss limitations of these studies. We draw on research from other mosquito species to outline the potential implications of natural Wolbachia infections in A. aegypti for disease control. To validate previous reports, we obtained a laboratory population of A. aegypti from New Mexico, USA, that harbors a natural Wolbachia infection, and we conducted field surveys in Kuala Lumpur, Malaysia, where a natural Wolbachia infection has also been reported. However, we were unable to detect Wolbachia in both the laboratory and field populations. Because the presence of naturally occurring Wolbachia in A. aegypti could have profound implications for Wolbachia‐based disease control programs, it is important to continue to accurately assess the Wolbachia status of target Aedes populations.

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Wolbachia affect behavior and possibly reproductive compatibility but not thermoresistance, fecundity, and morphology in a novel transinfected host, Drosophila nigrosparsa

Detcharoen

Arthofer

Jiggins

et al. 2020

Ecology and Evolution

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Wolbachia, intracellular endosymbionts, are estimated to infect about half of all arthropod species. These bacteria manipulate their hosts in various ways for their maximum benefits. The rising global temperature may accelerate species migration, and thus, horizontal transfer of Wolbachia may occur across species previously not in contact. We transinfected and then cured the alpine fly Drosophila nigrosparsa with Wolbachia strain wMel to study its effects on this species. We found low Wolbachia titer, possibly cytoplasmic incompatibility, and an increase in locomotion of both infected larvae and adults compared with cured ones. However, no change in fecundity, no impact on heat and cold tolerance, and no change in wing morphology were observed. Although Wolbachia increased locomotor activities in this species, we conclude that D. nigrosparsa may not benefit from the infection. Still, D. nigrosparsa can serve as a host for Wolbachia because vertical transmission is possible but may not be as high as in the native host of wMel, Drosophila melanogaster.

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Pathogenicity of Life-Shortening Wolbachia in Aedes albopictus after Transfer from Drosophila melanogaster

Cited by 69 publications

References 42 publications

Interaction ofWolbachiaand Bloodmeal Type in Artificially InfectedAedes albopictus(Diptera: Culicidae)

Interaction ofWolbachiaand Bloodmeal Type in Artificially InfectedAedes albopictus(Diptera: Culicidae)

An elusive endosymbiont: DoesWolbachiaoccur naturally inAedes aegypti?

Wolbachia affect behavior and possibly reproductive compatibility but not thermoresistance, fecundity, and morphology in a novel transinfected host, Drosophila nigrosparsa

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