Pathogenicity of Endocrine Dysregulation in Autism

Swierczynski, Adam

doi:10.20944/preprints201805.0359.v1

Cited by 2 publications

(1 citation statement)

References 278 publications

(291 reference statements)

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“…There is limited research on understanding the late diagnosis of autism in males and the impact this has had on them. In addition, Swierczynski ( 2018 ) highlights the need for cross-disciplinary linkages to create a unified body of knowledge that aims at better understanding ASD presentations and to aid the development of effective screening for and assessment of ASD and interventions for ASD. It is important to explore the impact of a late diagnosis and understand the factors which contribute to the late diagnosis of ASD, in both males and females.…”

Section: Introductionmentioning

confidence: 99%

Late diagnosis of autism: exploring experiences of males diagnosed with autism in adulthood

2022

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Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder associated with qualitative impairments in social interaction, social communication and restricted, repetitive behaviour (American Psychiatric Association, 2013). Symptoms of ASD are first evident in infancy and childhood. However, individuals presenting with less overt ASD symptomatology may only be diagnosed in adulthood, when the expectation of independence and productivity results in a growing crisis for the individual. This study applied an exploratory qualitative research design to explore first-hand experiences of ten adult males (25 years and above) who were diagnosed with autism during their adulthood. Purposive sampling was used to select participants through the Neurodiversity Centre, Cape Town, South Africa. In-depth one-on-one interviews, guided by a semi-structured interview schedule were conducted. The thematic analysis technique and NVivo 12 qualitative analysis software were used to organise the data and identify themes. Three key themes emerged: failure to diagnose ASD in childhood despite signs and symptoms, ramifications of missed/misdiagnosis in childhood and adulthood on psychological well-being and the impact of receiving a diagnosis of ASD in adulthood. Missed/misdiagnosis had serious implications for psychological well-being throughout childhood and into adulthood. Late diagnosis resulted in missed opportunities for early intervention to address impairments associated with ASD. Receiving a diagnosis provided an explanation for long standing difficulties, offered a way forward in terms of developing coping strategies and allowed for self-acceptance. The implications of these findings for the development of better early screening and assessment for ASD are discussed and future research pathways suggested.

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Section: Introductionmentioning

confidence: 99%

Late diagnosis of autism: exploring experiences of males diagnosed with autism in adulthood

2022

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Prognostic value of albumin-fibrinogen ratio in subarachnoid hemorrhage patients

Liu

Yu²,

Wen³

et al. 2021

Medicine

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Inflammation plays an important role in the pathophysiology of subarachnoid hemorrhage (SAH). Recent studies have indicated that the albumin to fibrinogen ratio (AFR) is a useful biomarker of inflammation. This research aimed to determine the ability of AFR to predict the prognosis of patients with SAH. A total of 440 patients with SAH who had been diagnosed within 72 hours of symptom onset were retrospectively reviewed. Clinical findings and laboratory data were retrieved from the hospital database. Functional outcome was measured according to the modified Rankin scale at 30 days. Logistic regression analysis was used to evaluate the correlation between AFR and the prognosis of patients with SAH. Receiver operating characteristic (ROC) analysis was performed to determine the prognostic ability of AFR at admission to predict the 30-day outcomes. The average age of all 440 patients with SAH was 56.75 ± 11.19 years and 31.4% (138) were male. Of these patients, 161 exhibited unfavorable outcomes at 30 days. According to the multivariate logistic regression analysis, the AFR was positively correlated with the outcome of patients with SAH (odds ratio 0.939, 95% confidence interval 0.885–0.996, P = .038). The ROC analysis revealed an area under the curve of 0.713 for AFR's ability to predict the 30-day outcomes. AFR is independently associated with the outcome of SAH patients. As a parameter that can be easily assessed at admission, AFR could be used to help the decision-making of clinical treatment.

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Pathogenicity of Endocrine Dysregulation in Autism

Cited by 2 publications

References 278 publications

Late diagnosis of autism: exploring experiences of males diagnosed with autism in adulthood

Late diagnosis of autism: exploring experiences of males diagnosed with autism in adulthood

Prognostic value of albumin-fibrinogen ratio in subarachnoid hemorrhage patients

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