Pathogenicity of Different Baboon
            <i>Herpesvirus Papio 2</i>
            Isolates Is Characterized by either Extreme Neurovirulence or Complete Apathogenicity

Rogers, Kristin M.; Ealey, Katie A.; Ritchey, Jerry W.; Black, Darla H.; Eberle, R.

doi:10.1128/jvi.77.20.10731-10739.2003

Cited by 19 publications

(33 citation statements)

References 16 publications

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“…The origins of HVP2 isolates have been reported elsewhere, as has their neurovirulence in mice (Eberle et al, 1995, 1998, and Rogers et al, 2003). HVP2nv strains OU1-76 & X313 and HVP2ap strains OU2-5 & A951 were used for most experiments.…”

Section: Methodsmentioning

confidence: 84%

“…While HVP2 isolates are equally pathogenic in their natural baboon host, testing of >20 HVP2 isolates in mice revealed that there are only two very distinct phenotypes with regard to their neurovirulence: either extremely neuroinvasive and lethal or nonvirulent (Rogers et al, 2003, 2005 and 2006). Neurovirulent HVP2 strains (HVP2nv) rapidly invade the CNS with destruction of CNS tissue that reflects that of BV in humans, while nonvirulent HVP2 strains (HVP2ap) invade the CNS much less efficiently, do not spread efficiently within the CNS, and cause only limited destruction of CNS tissue (Rogers et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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A single viral gene determines lethal cross-species neurovirulence of baboon herpesvirus HVP2

et al. 2014

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Alpha-herpesviruses can produce more severe infections in non-natural host species than in their natural host. Isolates of the baboon alpha-herpesvirus Papiine herpesvirus 2 (HVP2) are either very neurovirulent in mice (subtype nv) or non-virulent (subtype ap), but no such difference is evident in the natural baboon host. Comparative genome sequencing was used to identify subtype-specific sequence differences (SSDs) between HVP2nv and HVP2ap isolates. Some genes were identified that despite exhibiting sequence variation among isolates did not have any SSDs, while other genes had comparatively high levels of SSDs. Construction of genomic recombinants between HVP2nv and HVP2ap isolates mapped the mouse neurovirulence determinant to within three genes. Construction of gene-specific recombinants demonstrated that the UL39 ORF is responsible for determining the lethal neurovirulence phenotype of HVP2 in mice. These results demonstrate that differences in a single viral gene can determine the severity of herpesvirus infection in a non-natural host species.

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Section: Methodsmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

A single viral gene determines lethal cross-species neurovirulence of baboon herpesvirus HVP2

et al. 2014

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“…Like other tegument proteins, it may be involved in the early pathogenesis events. While the recombination involving UL42 and UL43 is unlikely to affect the biological properties of HVP-2, it is tempting to speculate that acquisition by HVP2 through recombination of non-SA8 pathogenesis genes, such as UL41, UL44, and perhaps UL36, may confer the characteristic HVP-2 neurovirulence in mice (47).…”

mentioning

confidence: 99%

“…However, B virus causes lethal encephalomyelitis when it is transmitted from its natural host, Asian macaques, to other primates, including humans (8,54). In mice, SA8 is not known to produce disease (45), while both HVP-2 and B virus have the ability to cause encephalitis, but the severity of infection varies widely among different strains (16,46,47). This broad spectrum of pathogenicity is an interesting feature of the genus Simplexvirus, and comparison of different strains may lead to the identification of simplexvirus genes responsible for neurovirulence.…”

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confidence: 99%

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The Complete Genome Sequence of Herpesvirus Papio 2 ( Cercopithecine Herpesvirus 16 ) Shows Evidence of Recombination Events among Various Progenitor Herpesviruses

Tyler

Severini

2006

J Virol

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We have sequenced the entire genome of herpesvirus papio 2 (HVP-2; Cercopithecine herpesvirus 16) strain X313, a baboon herpesvirus with close homology to other primate alphaherpesviruses, such as SA8, monkey B virus, and herpes simplex virus (HSV) type 1 and type 2. The genome of HVP-2 is 156,487 bp in length, with an overall GC content of 76.5%. The genome organization is identical to that of the other members of the genus Simplexvirus, with a long and a short unique region, each bordered by inverted repeats which end with an "a" sequence. All of the open reading frames detected in this genome were homologous and colinear with those of SA8 and B virus. The HSV gene RL1 (␥ 1 34.5; neurovirulence factor) is not present in HVP-2, as is the case for SA8 and B virus. The HVP-2 genome is 85% homologous to its closest relative, SA8. However, segment-bysegment bootstrap analysis of the genome revealed at least two regions that display closer homology to the corresponding sequences of B virus. The first region comprises the UL41 to UL44 genes, and the second region is located within the UL36 gene. We hypothesize that this localized and defined shift in homology is due to recombination events between an SA8-like progenitor of HVP-2 and a herpesvirus species more closely related to the B virus. Since some of the genes involved in these putative recombination events are determinants of virulence, a comparative analysis of their function may provide insight into the pathogenic mechanism of simplexviruses.

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Simplexviruses

2009

Simian Virology

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Pathogenicity of Different Baboon Herpesvirus Papio 2 Isolates Is Characterized by either Extreme Neurovirulence or Complete Apathogenicity

Cited by 19 publications

References 16 publications

A single viral gene determines lethal cross-species neurovirulence of baboon herpesvirus HVP2

A single viral gene determines lethal cross-species neurovirulence of baboon herpesvirus HVP2

The Complete Genome Sequence of Herpesvirus Papio 2 ( Cercopithecine Herpesvirus 16 ) Shows Evidence of Recombination Events among Various Progenitor Herpesviruses

Simplexviruses

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