Pathogenicity of BK virus on the urinary system

Krajewski, Wojciech; Kamińska, Dorota; Poterek, Adrian; Małkiewicz, Bartosz; Kłak, Jacek; Zdrojowy, Romuald; Janczak, Dariusz

doi:10.5173/ceju.2020.0034

Cited by 9 publications

(8 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The BK virus belongs to the polyomavirus family that is commonly acquired in childhood with a prevalence rate of up to 80% to 90% in adults [5]. The virus becomes latent in the urinary tract after infection and can be activated once the host becomes immunocompromised such as after transplantation.…”

Section: Discussionmentioning

confidence: 99%

BK-Virus-Induced Hemorrhagic Cystitis in a Patient With Graft-Versus-Host Disease

Jiffry¹,

Rangsipat²,

Tabares³

et al. 2023

Cureus

View full text Add to dashboard Cite

The BK virus is a polyomavirus known to particularly affect transplant recipients. An important complication caused by BK virus infection in bone marrow transplant patients is hemorrhagic cystitis. We present a 31-year-old male with a history of bone marrow transplantation complicated by graft-versus-host disease (GVHD) and was diagnosed with BK virus-related hemorrhagic cystitis. He presented with gross hematuria and suprapubic and penile pain for one week. He has a significant past medical history of acute Bcell lymphocytic leukemia for which he has successfully undergone allogenic bone marrow transplantation, which was complicated by GVHD. Imaging revealed significant bladder wall thickening which prompted an evaluation for BK virus-induced hemorrhagic cystitis. A urinary specimen was sent for BK virus polymerase chain reaction (PCR) which was strongly positive, confirming the infection. He was managed supportively throughout his hospitalization and improved with symptomatic management alone. Our case demonstrates one of the main complications caused by the BK virus in allogeneic bone marrow transplant patients in the setting of GVHD and is an important differential to keep in mind when treating patients presenting with hematuria after bone marrow transplantation.

show abstract

Section: Discussionmentioning

confidence: 99%

BK-Virus-Induced Hemorrhagic Cystitis in a Patient With Graft-Versus-Host Disease

Jiffry¹,

Rangsipat²,

Tabares³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…The BK virus can appear in early childhood and have an asymptomatic course. It is found in several parts of the body and is a frequent colonizer of renal epithelial tubular cells and urothelial cells [52,53]. From 2000 to 2009, there was an increase in the prevalence of BK virus infection, from 7 to 24% in RTRs [52], with an adjusted RR 2.9-8.0 times higher for UC in patients positive to BK virus as opposed to negative ones [52,54].…”

Section: Renal Transplantation and Bladder Cancermentioning

confidence: 99%

Urological Cancers and Kidney Transplantation: a Literature Review

Hernández-Gaytán

Rodríguez-Covarrubias

Castillejos-Molina

et al. 2021

Curr Urol Rep

View full text Add to dashboard Cite

Purpose of ReviewThe aim of this review is to provide an overview of epidemiology, risk factors, and treatment of urological malignancies in renal transplant recipients (RTR). Recent Findings Although optimal immunosuppressive therapy and cancer management in these patients remain controversial, adherence to general guidelines is recommended. Summary Kidney transplantation is recognized as the standard of care for the treatment of end-stage renal disease (ESRD) as it offers prolonged survival and better quality of life. In the last decades, survival of RTRs has increased as a result of improved immunosuppressive therapy; nonetheless, the risk of developing cancer is higher among RTRs compared to the general population. Urological malignancies are the second most common after hematological cancer and often have more aggressive behavior and poor prognosis.

show abstract

“…Based on genome sequence diversity, BKV has be divided into six genotypes, in which genotype I is considered as the most frequent worldwide (~80%), followed by genotype IV (15%) ( Kotla et al., 2021 ). BKV is ubiquitous around the globe, with up to 90% of adults being seropositive, and the transmission routes of BKV were speculated through direct contact or fecal-oral transmission during childhood ( Krajewski et al., 2020 ; Furmaga et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

BK polyomavirus: latency, reactivation, diseases and tumorigenesis

Zhou,

Zhu,

2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

The identification of the first human polyomavirus BK (BKV) has been over half century, The previous epidemiological and phylogenetic studies suggest that BKV prevailed and co-evolved with humans, leading to high seroprevalence all over the world. In general, BKV stays latent and symptomless reactivation in healthy individuals. BKV has been mainly interlinked with BKV-associated nephropathy (BKVAN) in kidney-transplant recipients and hemorrhagic cystitis (HC) in hematopoietic stem cell transplant recipients (HSCTRs). However, the mechanisms underlying BKV latency and reactivation are not fully understood and lack of extensive debate. As Merkel cell polyomavirus (MCV) was identified as a pathogenic agent of malignant cutaneous cancer Merkel cell carcinoma (MCC) since 2008, linking BKV to tumorigenesis of urologic tumors raised concerns in the scientific community. In this review, we mainly focus on advances of mechanisms of BKV latency and reactivation, and BKV-associated diseases or tumorigenesis with systematical review of formerly published papers following the PRISMA guidelines. The potential tumorigenesis of BKV in two major types of cancers, head and neck cancer and urologic cancer, was systematically updated and discussed in depth. Besides, BKV may also play an infectious role contributing to HIV-associated salivary gland disease (HIVSGD) presentation. As more evidence indicates the key role of BKV in potential tumorigenesis, it is important to pay more attention on its etiology and pathogenicity in vitro and in vivo.

show abstract

Pathogenicity of BK virus on the urinary system

Cited by 9 publications

References 119 publications

BK-Virus-Induced Hemorrhagic Cystitis in a Patient With Graft-Versus-Host Disease

BK-Virus-Induced Hemorrhagic Cystitis in a Patient With Graft-Versus-Host Disease

Urological Cancers and Kidney Transplantation: a Literature Review

BK polyomavirus: latency, reactivation, diseases and tumorigenesis

Contact Info

Product

Resources

About