Pathogenicity and virulence of
            <i>Francisella tularensis</i>

Degabriel, Manon; Valeva, Stanimira; Boisset, Sandrine; Henry, Thomas

doi:10.1080/21505594.2023.2274638

Cited by 2 publications

(1 citation statement)

References 210 publications

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“…F. tularensis is primarily transmitted via tick or contact with infected animals and can cause disease in healthy, immunocompetent hosts because it is a more virulent intracellular pathogen. 5 Because of the zoonotic concern of F. tularensis following identification of the genus Francisella on blood cultures, PCR and sequencing was performed to ensure F. tularensis was not present.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Francisella philomiragia bacteremia in a dog

McAtee,

Wood,

Daniels

et al. 2024

Veterinary Internal Medicne

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To describe the diagnosis and successful treatment of systemic francisellosis in a dog. An 11‐year‐old female spayed Labrador retriever presented for progressive lethargy, hyporexia, and cough. The dog was febrile with a neutrophilia, nonregenerative anemia, thrombocytopenia, and had increased activity in serum of liver‐derived enzymes. Francisella philomiragia was isolated from aerobic blood culture. The dog was treated for 6 weeks with enrofloxacin orally. Repeated aerobic blood cultures after 2 and 6 weeks of antibiotic therapy were negative. The dog was clinically normal 7 months after diagnosis with no evidence of relapse.

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Section: Discussionmentioning

confidence: 99%

Treatment of Francisella philomiragia bacteremia in a dog

McAtee,

Wood,

Daniels

et al. 2024

Veterinary Internal Medicne

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Phenotypic and transcriptional characterization of F. tularensis LVS during transition into a viable but non-culturable state

Cantlay,

Garrison,

Patterson

et al. 2024

Front. Microbiol.

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Francisella tularensis is a gram-negative, intracellular pathogen which can cause serious, potentially fatal, illness in humans. Species of F. tularensis are found across the Northern Hemisphere and can infect a broad range of host species, including humans. Factors affecting the persistence of F. tularensis in the environment and its epidemiology are not well understood, however, the ability of F. tularensis to enter a viable but non-culturable state (VBNC) may be important. A broad range of bacteria, including many pathogens, have been observed to enter the VBNC state in response to stressful environmental conditions, such as nutrient limitation, osmotic or oxidative stress or low temperature. To investigate the transition into the VBNC state for F. tularensis, we analyzed the attenuated live vaccine strain, F. tularensis LVS grown under standard laboratory conditions. We found that F. tularensis LVS rapidly and spontaneously enters a VBNC state in broth culture at 37°C and that this transition coincides with morphological differentiation of the cells. The VBNC bacteria retained an ability to interact with both murine macrophages and human erythrocytes in in vitro assays and were insensitive to treatment with gentamicin. Finally, we present the first transcriptomic analysis of VBNC F. tularensis, which revealed clear differences in gene expression, and we identify sets of differentially regulated genes which are specific to the VBNC state. Identification of these VBNC specific genes will pave the way for future research aimed at dissecting the molecular mechanisms driving entry into the VBNC state.

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Pathogenicity and virulence of Francisella tularensis

Cited by 2 publications

References 210 publications

Treatment of Francisella philomiragia bacteremia in a dog

Treatment of Francisella philomiragia bacteremia in a dog

Phenotypic and transcriptional characterization of F. tularensis LVS during transition into a viable but non-culturable state

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