Pathogenic Yersinia enterocolitica 2/O:9 and Yersinia pseudotuberculosis 1/O:1 strains isolated from human and non-human sources in the Plateau State of Nigeria

Okwori, A.E.J.; Martínez, Pilar Ortiz; Fredriksson-Ahomaa, Maria; Agina, S. E.; Korkeala, Hannu

doi:10.1016/j.fm.2009.06.001

Cited by 47 publications

(40 citation statements)

References 24 publications

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“…Yersiniosis is the third most frequent bacterial disease causing human enteric infections in Europe [10], but reports of this disease are extremely infrequent in developing countries. In West Africa, only few countries reported the isolation of Yersinia from clinical cases [11–20], most likely because an active search for these bacteria is not performed. This is supported by the observation that in Nigeria, where studies were carried out to specifically look for this pathogen in human and animal samples, Yersinia strains were isolated [15–19].…”

Section: Discussionmentioning

confidence: 99%

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Yersinia enterocolitica, a Neglected Cause of Human Enteric Infections in Côte d’Ivoire

et al. 2017

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BackgroundEnteropathogenic Yersinia circulate in the pig reservoir and are the third bacterial cause of human gastrointestinal infections in Europe. In West Africa, reports of human yersiniosis are rare. This study was conducted to determine whether pathogenic Yersinia are circulating in pig farms and are responsible for human infections in the Abidjan District.Methodology/Principal findingsFrom June 2012 to December 2013, pig feces were collected monthly in 41 swine farms of the Abidjan district. Of the 781 samples collected, 19 Yersinia strains were isolated in 3 farms: 7 non-pathogenic Yersinia intermedia and 12 pathogenic Yersinia enterocolitica bioserotype 4/O:3. Farm animals other than pigs and wild animals were not found infected. Furthermore, 2 Y. enterocolitica 4/O:3 strains were isolated from 426 fecal samples of patients with digestive disorders. All 14 Y. enterocolitica strains shared the same PFGE and MLVA profile, indicating their close genetic relationship. However, while 6 of them displayed the usual phage type VIII, the other 8 had the highly infrequent phage type XI. Whole genome sequencing and SNP analysis of individual colonies revealed that phage type XI strains had unusually high rates of mutations. These strains displayed a hypermutator phenotype that was attributable to a large deletion in the mutS gene involved in DNA mismatch repair.Conclusions/SignificanceThis study demonstrates that pathogenic Y. enterocolitica circulate in the pig reservoir in Côte d'Ivoire and cause human infections with a prevalence comparable to that of many developed countries. The paucity of reports of yersiniosis in West Africa is most likely attributable to a lack of active detection rather than to an absence of the microorganism. The identification of hypermutator strains in pigs and humans is of concern as these strains can rapidly acquire selective advantages that may increase their fitness, pathogenicity or resistance to commonly used treatments.

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Section: Discussionmentioning

confidence: 99%

“…enterocolitica pigs, bovine and sheep in Nigeria [20–23]. In contrast, a survey of the pig reservoir in Senegal [24] and Burkina Faso [25] did not identify any Yersinia strains.…”

Section: Introductionmentioning

confidence: 99%

Yersinia enterocolitica, a Neglected Cause of Human Enteric Infections in Côte d’Ivoire

et al. 2017

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“…These conditions no doubt provided pointers to some of the high prevalence values we recorded, being avenues for bacterial infection, re-infecton and dissemination of existing infections amongst previously unaffected animals. Several reports have been presented on the isolation of Yersinia species from a variety of animals and human beings (Shepel et al, 2001., Skiriken, 2004., Okwori et al, 2008Okwori et al, ., 2009); descriptions of observed clinical manifestations or pathoanotomical changes are sparse (Hurvell, 1981;Schiemann, 1989). Despite the successes in excluding select pathogens (Barry and Strelow, 2008;Morton and Capuono, 2008;Solnick et al, 1999) of NHP colonies, elimination of many other infectious diseases from NHP colonies has proven difficult for several reasons.…”

Section: Discussionmentioning

confidence: 99%

Spectrum of Bacterial Isolates from Captive Non-Human Primates in Jos Wild Life Park

2013

IOSR-JAVS

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“…Direct transmission may occur when basic hygienic and hand-washing habits are inadequate (Okwori et al 2009). Lee et al (1990) reported Y. enterocolitica O:3 infections among infants who were probably exposed to infection by their caretakers.…”

Section: Person-to-person Transmission Occurs Via Contaminated Handsmentioning

confidence: 99%

Enteropathogenic Yersinia spp.

Fredriksson-Ahomaa

2014

Zoonoses - Infections Affecting Humans and Animals

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Yersinia enterocolitica and Yersinia pseudotuberculosis can cause enteric yersiniosis among humans and animals. The infection is typically acquired through contaminated food but it can also be transmitted directly through human or animal contact. Common symptoms are diarrhoea, abdominal pain and fever but sometimes sequelae as joint pain and skin rash occur. The severity of the infection depends on the age and immunity of the infected person, the virulence of the strain and the infection dose. Y. enterocolitica and Y. pseudotuberculosis differ clearly from each other both pheno-and genotypically. Y. enterocolitica species consists of a very heterogeneous group of bacteria and not all Y. enterocolitica strains are pathogenic. Y. pseudotuberculosis strains show little variation in biochemical reactions and they are all considered to be pathogenic. Both plasmid and chromosomal encoded virulence factors are needed for Yersinia pathogenicity and all pathogenic strains carry a virulence plasmid which essential for the bacteria to multiply and disseminate in the host. Yersinia strains can grow at low temperatures and under both aerobic and anaerobic conditions but they are heat sensitive. The isolation and identification of enteropathogenic Yersinia is difficult and time consuming, especially when food and environmental samples are studied. More accurate methods should be designed for isolation and identification of Yersinia spp. and more information is needed about transmission routes and sources of enteropathogenic Yersinia strains.

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Pathogenic Yersinia enterocolitica 2/O:9 and Yersinia pseudotuberculosis 1/O:1 strains isolated from human and non-human sources in the Plateau State of Nigeria

Cited by 47 publications

References 24 publications

Yersinia enterocolitica, a Neglected Cause of Human Enteric Infections in Côte d’Ivoire

Yersinia enterocolitica, a Neglected Cause of Human Enteric Infections in Côte d’Ivoire

Spectrum of Bacterial Isolates from Captive Non-Human Primates in Jos Wild Life Park

Enteropathogenic Yersinia spp.

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