Pathogenic viruses of the respiratory tract – A review

Kabir, Md. Shahidul

doi:10.12980/apjtd.7.2017d6-423

Cited by 2 publications

(7 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies included in this review were those that either reported on viruses that infects human or on surrogate of human viruses adapted for different experimental models. The human viruses considered were those that belong to any of the classes of viruses known to infect the human respiratory tract including influenza viruses, RSV, parainfluenza viruses (PIVs), metapneumovirus, coronavirus, respiratory AdV, RV, bocavirus, enterovirus, and parechovirus ( 2 , 6 , 7 ). Only studies done on animals, humans or cell lines, those that utilized constituents of edible foods as an antiviral intervention agent and those that reported some forms of outcome following treatment of virus-infected models with the intervention agents were considered for inclusion.…”

Section: Pubmedmentioning

confidence: 99%

“…Several people suffer yearly from respiratory tract infections caused by viruses and a host of other organisms ( 1 ). Infections of the respiratory tracts are leading cause of death in children below 5 years with up to 500,000 annual deaths globally ( 2 ). Respiratory viruses are major contributor to respiratory tract infections.…”

Section: Introductionmentioning

confidence: 99%

“…This consequently leads to over 3 million hospitalization and about 60,000 deaths amongst infected persons ( 5 ). Over 200 strains of Respiratory viruses belonging to the families of adenoviridae, parvoviridae, orthomyxoviridae, paramyxoviridae, picornaviridae, and coronaviridae have been reported ( 2 ). Some notable examples of pathogenic viruses known to infect human respiratory tract includes influenza viruses, human parainfluenza virus (hPIV), RSV, adenovirus (AdV), rhinovirus (RV), enterovirus, parechovirus, human metapneumovirus, coronavirus, human bocavirus, parvovirus (type 4 and 5), and mimivirus ( 2 , 6 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

“…These viruses readily infect the upper respiratory tracts and cause mild infections including cold and flu. However, symptoms aggravates once infections gets to the lower respiratory tracts ( 2 , 8 ). Most respiratory viruses have seasonal outbreaks while some like hPIV infection occurs all year round ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

“…Some of the general symptoms of respiratory viruses include seasonal colds, bronchiolitis (especially with RSV), acute otitis, sinisitis, croup (mainly by hPIV), worsening of chronic obstructive pulmonary disease (COPD) and asthma, pneumonia ( 7 ). The most vulnerable groups to respiratory virus infection include immunocompromised patients, elderly, and infants ( 2 , 7 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Plant-Derived Food Grade Substances (PDFGS) Active Against Respiratory Viruses: A Systematic Review of Non-clinical Studies

et al. 2021

View full text Add to dashboard Cite

Human diet comprises several classes of phytochemicals some of which are potentially active against human pathogenic viruses. This study examined available evidence that identifies existing food plants or constituents of edible foods that have been reported to inhibit viral pathogenesis of the human respiratory tract. SCOPUS and PUBMED databases were searched with keywords designed to retrieve articles that investigated the effect of plant-derived food grade substances (PDFGS) on the activities of human pathogenic viruses. Eligible studies for this review were those done on viruses that infect the human respiratory tract. Forty six (46) studies met the specified inclusion criteria from the initial 5,734 hits. The selected studies investigated the effects of different PDFGS on the infectivity, proliferation and cytotoxicity of different respiratory viruses including influenza A virus (IAV), influenza B virus (IBV), Respiratory syncytial virus (RSV), human parainfluenza virus (hPIV), Human coronavirus NL63 (HCoV-NL63), and rhinovirus (RV) in cell lines and mouse models. This review reveals that PDFGS inhibits different stages of the pathological pathways of respiratory viruses including cell entry, replication, viral release and viral-induced dysregulation of cellular homeostasis and functions. These alterations eventually lead to the reduction of virus titer, viral-induced cellular damages and improved survival of host cells. Major food constituents active against respiratory viruses include flavonoids, phenolic acids, tannins, lectins, vitamin D, curcumin, and plant glycosides such as glycyrrhizin, acteoside, geniposide, and iridoid glycosides. Herbal teas such as guava tea, green and black tea, adlay tea, cistanche tea, kuding tea, licorice extracts, and edible bird nest extracts were also effective against respiratory viruses in vitro. The authors of this review recommend an increased consumption of foods rich in these PDFGS including legumes, fruits (e.g berries, citrus), tea, fatty fish and curcumin amongst human populations with high prevalence of respiratory viral infections in order to prevent, manage and/or reduce the severity of respiratory virus infections.

show abstract

Section: Pubmedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Plant-Derived Food Grade Substances (PDFGS) Active Against Respiratory Viruses: A Systematic Review of Non-clinical Studies

et al. 2021

View full text Add to dashboard Cite

show abstract

Pathogen Profile of Children Hospitalised with Severe Acute Respiratory Infections during COVID-19 Pandemic in the Free State Province, South Africa

Ogunbayo

Mogotsi

Sondlane

et al. 2022

IJERPH

View full text Add to dashboard Cite

Severe acute respiratory infections (SARI) contribute to mortality in children ≤5 years. Their microbiological aetiologies are often unknown and may be exacerbated in light of coronavirus disease 19 (COVID-19). This study reports on respiratory pathogens in children ≤5 years (n = 84) admitted with SARI during and between the second and third waves of COVID-19 infection in South Africa. Nasopharyngeal/oropharyngeal swabs collected were subjected to viral detection using QIAstat-Dx® Respiratory SARS-CoV-2 Panel. The results revealed viral positivity and negativity detection rates of 88% (74/84) and 12% (10/84), respectively. Of the 21 targeted pathogens, human rhinovirus/enterovirus (30%), respiratory syncytial virus (RSV; 26%), and severe acute respiratory syndrome coronavirus 2 (24%) were mostly detected, with other viruses being 20% and a co-infection rate of 64.2% (54/84). Generally, RSV-positive samples had lower Ct values, and fewer viruses were detected during the third wave. Changes in the circulation patterns of respiratory viruses with total absence of influenza virus could be attributed to measures against COVID-19 transmission, which may result in waned immunity, thereby increasing susceptibility to severe infections in the following season. High viral co-infection rate, as detected, may complicate diagnosis. Nonetheless, accurate identification of the pathogens may guide treatment decisions and infection control.

show abstract

Pathogenic viruses of the respiratory tract – A review

Cited by 2 publications

References 57 publications

Plant-Derived Food Grade Substances (PDFGS) Active Against Respiratory Viruses: A Systematic Review of Non-clinical Studies

Plant-Derived Food Grade Substances (PDFGS) Active Against Respiratory Viruses: A Systematic Review of Non-clinical Studies

Pathogen Profile of Children Hospitalised with Severe Acute Respiratory Infections during COVID-19 Pandemic in the Free State Province, South Africa

Contact Info

Product

Resources

About