Pathogenic role of platelets in rheumatoid arthritis and systemic autoimmune diseases

Harifi, G.; Sibilia, Jean

doi:10.15537/smj.2016.4.14768

Cited by 36 publications

(33 citation statements)

References 59 publications

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“…In the meantime these results were contradictory to others. 11,14,31 To what extent this controversy would hinder the inclusion of PIs in disease activity score of RA remains to be seen. This controversy would be similar or lower than the discrepancy between the objective parameter ESR or CRP and the subjective ones, number of swollen and tender joints and VAS in DAS28.…”

Section: Discussionmentioning

confidence: 99%

“…Thrombocytosis was described in RA patients during active stages of the disease, then counts decrease upon remission. 11 PIs are platelet parameters that could be easily obtained by modern automated blood cell analyzers. They include mean platelet volume (MPV), platelet count, platelet distribution width (PDW), plateletcrit (PCT), and platelet large cell ratio (P-LCR).…”

Section: Introductionmentioning

confidence: 99%

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<p>Value of Platelet Distribution Width and Mean Platelet Volume in Disease Activity Score of Rheumatoid Arthritis</p>

Khaled¹,

NasrEldin²,

Makarem³

et al. 2020

JIR

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Point your SmartPhone at the code above. If you have a QR code reader the video abstract will appear. Or use: https://youtu.be/uIRDqugjJv4 Background and Objective: Disease activity score 28 (DAS28) for rheumatoid arthritis (RA) is the commonly used DAS; it relies on clinical parameters that could be subjective. This work aimed to create a more accurate DAS for RA and assess its validity. Patients and Methods: The study included 98 RA patients and 53 matched controls; they were interviewed, clinically examined, their visual analogue scales (VAS) were reported, and then blood samples were withdrawn for erythrocyte sedimentation rate (ESR), complete blood count (CBC), and C-reactive protein (CRP). Platelet indices (PIs) were obtained from the CBC including Plt (platelet count), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT). DAS28 was calculated for each patient using RheumaHelper mobile software. Minitab Statistical Package ® and SPSS v20 software were used for data analysis. Results and Conclusions: Results revealed perfect matching between patients and controls as regarding age and gender. ESR, CRP and PDW were significantly higher in patients than controls; also positive correlations were detected among these variables. A new DAS for RA was developed; ESR, CRP, PDW and MPV were the components for this index. Further analyses showed that this new score was significantly higher in patients than controls and correlated with DAS28 of the patients. Furthermore the new score could identify RA patients from healthy subjects (cut off value < −0.79) and stratified RA patients according to their disease activity into low, intermediate, high, or in remission. Conclusively, we developed a more precise, easily obtained new DAS for RA. This new DAS has both diagnostic/prognostic values in patients with RA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Value of Platelet Distribution Width and Mean Platelet Volume in Disease Activity Score of Rheumatoid Arthritis</p>

Khaled¹,

NasrEldin²,

Makarem³

et al. 2020

JIR

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“…[22] The MPV is significantly lower in both RA and Ankylosing Spondylitis (AS) patients with active disease as compared with controls. [23] Other studies have shown that MPV is correlated with clinical disease activity indices in both RA and AS patients. [17,4] Moreover, platelet indices were substantially decreased after therapy.…”

Section: Discussionmentioning

confidence: 95%

Association of Platelet Indices With Disease Activity in Rheumatoid Arthritis

Shuba¹,

Praba²,

Prithiviraaj³

2018

jemds

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BACKGROUND Rheumatoid Arthritis (RA) is a chronic autoimmune inflammatory disease of unknown aetiology that mainly affects peripheral joints in a symmetric pattern. Prevalence of RA is approximately 1% worldwide, being two to three times more common in women than men. Effective management in RA requires close monitoring of disease activity. Platelet activation is an important event in synovial inflammation, but very few studies have used platelet indices to assess inflammation. Thus, the aim of the study was to correlate the platelet indices (platelet count, mean platelet volume and platelet distribution width) with disease activity in Rheumatoid Arthritis. MATERIALS AND METHODS This descriptive comparative study was conducted among 60 RA patients and 30 healthy controls within the age group of 30 to 70 years. Every consecutive RA patient who attended the Rheumatology Outpatient Department was included in the study. The severity of RA was assessed by the Disease Activity Score Calculator for Rheumatoid Arthritis (DAS-28). The platelet indices assessed in the study include platelet count, Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) obtained from their CBC report. The study population was divided into three groups. Group I (Moderate disease activity) with DAS-28 score of 3.2-5.1; Group II (High disease activity) with DAS-28 score above 5.1. Thirty patients in Group I and thirty in Group II were taken for the study. Group III: 30 healthy controls who attended the Master Health CheckUp Department. Data analysis was done by using SPSS software and independent t-test. P value < 0.05 was taken as statistically significant. RESULTS There was statistically significant increase in platelet count, decrease in MPV and PDW in high-grade RA patients when compared with normal individuals (p= 0.004, p= 0.001, p= 0.019 respectively). We also found similar statistical significance between high and moderate grade RA patients (p= 0.001 for platelet count, p= 0.007 for MPV and p= 0.012 for PDW). CONCLUSION Our study suggests that platelet indices can be considered as inflammatory markers for disease activity in RA. However, further studies with larger number of patients are warranted to cross validate our findings.

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“…The bubble-platelet interaction is regularly spotlighted in DCS. However, beyond its well-known thrombotic role, it would also be interesting to consider the involvement of the platelets in the immune response ( Harifi and Sibilia, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Reduction in the Level of Plasma Mitochondrial DNA in Human Diving, Followed by an Increase in the Event of an Accident

Blatteau¹,

Gaillard

Maistre

et al. 2018

Front. Physiol.

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Circulating mitochondrial DNA (mtDNA) is receiving increasing attention as a danger-associated molecular pattern in conditions such as autoimmunity or trauma. In the context of decompression sickness (DCS), the course of which is sometimes erratic, we hypothesize that mtDNA plays a not insignificant role particularly in neurological type accidents. This study is based on the comparison of circulating mtDNA levels in humans presenting with various types of diving accidents, and punctured upon their admission at the hyperbaric facility. One hundred and fourteen volunteers took part in the study. According to the clinical criteria there were 12 Cerebro DCS, 57 Medullary DCS, 15 Vestibular DCS, 8 Ctrl+ (accident-free divers), and 22 Ctrl- (non-divers). This work demonstrates that accident-free divers have less mtDNA than non-divers, which leads to the assumption that hyperbaric exposure degrades the mtDNA. mtDNA levels are on average greater in divers with DCS compared with accident-free divers. On another hand, the amount of double strand DNA (dsDNA) is neither significantly different between controls, nor between the different DCS types. Initially the increase in circulating oligonucleotides was attributed to the destruction of cells by bubble abrasion following necrotic phenomena. If there really is a significant difference between the Medullary DCS and the Ctrl-, this difference is not significant between these same DCS and the Ctrl+. This refutes the idea of massive degassing and suggests the need for new research in order to verify that oxidative stress could be a key element without necessarily being sufficient for the occurrence of a neurological type of accident.

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Pathogenic role of platelets in rheumatoid arthritis and systemic autoimmune diseases

Cited by 36 publications

References 59 publications

<p>Value of Platelet Distribution Width and Mean Platelet Volume in Disease Activity Score of Rheumatoid Arthritis</p>

<p>Value of Platelet Distribution Width and Mean Platelet Volume in Disease Activity Score of Rheumatoid Arthritis</p>

Association of Platelet Indices With Disease Activity in Rheumatoid Arthritis

Reduction in the Level of Plasma Mitochondrial DNA in Human Diving, Followed by an Increase in the Event of an Accident

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