Pathogenic role of ion channels in pulmonary arterial hypertension

Tang, Haiyang; Zheng, Qiuyu; Wang, Jian

doi:10.1113/ep086426

Cited by 3 publications

(1 citation statement)

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“…Normally, the vagal and sympathetic excitements contain circadian rhythms, and the corresponding regulation of blood pressure also exhibits circadian rhythm. However, the disrupted sympathetic nerve rhythm of patients with chronic insomnia leads to disordered blood pressure in circadian rhythm (i.e., the formation of non-dipper blood pressure) [15], and chronic intractable insomnia impairs the immune system. Patients with chronic intractable often have high levels of inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

Effects of Chronic Intractable Insomnia on Inflammatory Cytokines, Blood Pressure Characteristics, and Antihypertensive Efficacy in Hypertensive Patients

Wang

Yang

et al. 2018

Med Sci Monit

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BackgroundThis study investigated the changes in blood pressure and inflammatory cytokines in patients with chronic intractable insomnia, and explored the effects of chronic intractable insomnia on antihypertensive efficacy.Material/MethodsA total of 248 patients with hypertension admitted to our hospital from 2008 to 2017 were enrolled. We enrolled 124 patients without chronic insomnia in the control group, while 124 patients with chronic insomnia were included in the treatment group. The treatment group received estazolam and was further subdivided into the effective group (n=96) and the ineffective group (n=28) according to Sleep Dysfunction Rating Scale (SDRS) scores. Sleep quality before and after treatment was determined.ResultsAntihypertensive treatment with eplerenone (50 mg) significantly reduced SDRS scores, C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), matrix metalloproteinase-9 (MMP-9), serum intercellular adhesion molecules (sICAM), and IL-1β levels, as well as systolic blood pressures (SBP) and diastolic blood pressures (DBP), with elevation of non-dipper blood pressure rhythm (P<0.05). The inhibition of intractable insomnia significantly downregulated SBP and DBP, as well as serum inflammatory cytokines such as CRP and TNF-α, showing a favorable effect on antihypertensive function.ConclusionsAlleviation of chronic intractable insomnia facilitates hypertension therapy through decreasing levels of inflammatory cytokines and the proportion of non-dipper blood pressure rhythm, which offers insights for the treatment of hypertension.

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Section: Discussionmentioning

confidence: 99%