Pathogenic Risk Factors and Associated Outcomes in the Bullous Variant of Central Serous Chorioretinopathy

Kang, Hyun Goo; Woo, Se Joon; Lee, Joo Yong; Cho, Han Joo; Ahn, Jeeyun; Yang, Yun Sik; Jo, Young–Joon; Kim, Seong-Woo; Kim, Sang Jin; Sagong, Min; Lee, Jae Jung; Kang, Moon-Sik; Park, Hyo Song; Byeon, Suk Ho; Kim, Sung Soo; Kang, Se Woong; Park, Kyu Hyung; Lee, Christopher S.

doi:10.1016/j.oret.2022.04.015

Cited by 2 publications

(12 citation statements)

References 26 publications

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“…Focal or multifocal retinal detachments frequently are identified in dogs with SARDS 9,24,25 . This finding is also commonly found in a cause of acute painless vision disturbance in humans, central serous chorioretinopathy (CSCR) 26‐28 . Hypercortisolism is common in people with CSCR 29‐33 .…”

Section: Discussionmentioning

confidence: 99%

Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome

Lynch

Ruterbories

Robertson

et al. 2023

Veterinary Internal Medicne

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Background Sudden acquired retinal degeneration syndrome (SARDS) is a common cause of irreversible blindness in dogs. It bears clinical resemblance to hypercortisolism, which can be associated with hypercoagulability. The role of hypercoagulability in dogs with SARDS is unknown. Objective Determine hemostatic profiles in dogs with SARDS. Animals Prospective pilot study: Dogs with a history of SARDS (n = 12). Prospective case‐control study: Dogs with recent onset of SARDS (n = 7) and age‐, breed‐, and sex‐matched controls (n = 7). Methods Prospective pilot study: We performed thromboelastography (TEG). Prospective case‐control study: Dogs had CBC, serum biochemistry, urinalysis, TEG, fibrinogen concentration, antithrombin activity, D‐dimers, thrombin‐antithrombin complexes, and optical platelet aggregometry performed. Results Prospective pilot study: 9/12 dogs with a history of SARDS were hypercoagulable with increased TEG G value and 2/3 had hyperfibrinogenemia. Case‐control study: All dogs with SARDS and 5/7 controls were hypercoagulable based on TEG G value. Dogs with SARDS had significantly higher G values (median, 12.7 kdynes/s; range, 11.2‐25.4; P = .04) and plasma fibrinogen concentration (median, 463 mg/dL; range, 391‐680; P < .001) compared to controls. Conclusions and Clinical Importance Hypercoagulability was common in both dogs with SARDS and controls, but dogs with SARDS were significantly more hypercoagulable on TEG. The role of hypercoagulability in the pathogenesis of SARDS remains to be determined.

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Section: Discussionmentioning

confidence: 99%

Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome

Lynch

Ruterbories

Robertson

et al. 2023

Veterinary Internal Medicne

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“…The bullous variant of central serous chorioretinopathy (CSC) is a rare and severe form of chronic CSC, characterized by multifocal fluid leakage, bullous retinal detachment, and shifting subretinal fluid. [1][2][3] Compared with patients with non-bullous chronic CSC, patients with the bullous variant of CSC are more prone to developing multiple pigment epithelial detachments (PEDs) and retinal pigment epithelium (RPE) tears. [2][3][4] Various treatment options have been explored for the bullous variant of CSC, including photodynamic therapy (PDT), focal photocoagulation, intravitreal anti-vascular endothelial growth factor injections, corticosteroid withdrawal, and vitrectomy.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Compared with patients with non-bullous chronic CSC, patients with the bullous variant of CSC are more prone to developing multiple pigment epithelial detachments (PEDs) and retinal pigment epithelium (RPE) tears. [2][3][4] Various treatment options have been explored for the bullous variant of CSC, including photodynamic therapy (PDT), focal photocoagulation, intravitreal anti-vascular endothelial growth factor injections, corticosteroid withdrawal, and vitrectomy. [1,[3][4][5] A recent study found that PDT is the most common initial treatment for the bullous variant of CSC.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4] Various treatment options have been explored for the bullous variant of CSC, including photodynamic therapy (PDT), focal photocoagulation, intravitreal anti-vascular endothelial growth factor injections, corticosteroid withdrawal, and vitrectomy. [1,[3][4][5] A recent study found that PDT is the most common initial treatment for the bullous variant of CSC. [3] However, it is crucial to acknowledge the potential for RPE tears as a serious complication of PDT in eyes with PEDs.…”

Section: Introductionmentioning

confidence: 99%

“…[1,[3][4][5] A recent study found that PDT is the most common initial treatment for the bullous variant of CSC. [3] However, it is crucial to acknowledge the potential for RPE tears as a serious complication of PDT in eyes with PEDs. [6,7] This case report presents a unique instance of the bullous variant of CSC with a large PED complicated by a giant RPE tear following PDT.…”

Section: Introductionmentioning

confidence: 99%

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Giant retinal pigment epithelial tear following photodynamic therapy for the bullous variant of central serous chorioretinopathy: A case report

Kimura,

Miura

2024

Medicine

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Rationale: The bullous variant of central serous chorioretinopathy (CSC) is a severe form of chronic CSC. Patients with the bullous variant of CSC have an increased risk of experiencing multiple pigment epithelial detachments (PEDs) and retinal pigment epithelium (RPE) tears. Photodynamic therapy (PDT) is a treatment for the bullous variant of CSC. RPE tear is a possible postoperative complication of PDT for eyes with PEDs. To our knowledge, no cases of giant RPE tears following PDT for the bullous variant of CSC have been reported previously. This case report presents the first instance of a giant RPE tear after half-time PDT for the bullous variant of CSC, accompanied by a series of images depicting the tear development. Patient concerns: A 63-year-old male patient presented with rapidly deteriorating vision in his left eye over a 3-month period. He also reported a previous episode of vision loss in his right eye 2 years prior. Best-corrected visual acuity (BCVA) in the left eye was 0.2. Diagnosis: The right eye was diagnosed with chronic non-bullous CSC, while the left eye was diagnosed with the bullous variant of CSC with a large PED. Interventions: Half-time PDT was administered to the left eye. Outcomes: One month after half-time PDT, a giant RPE tear exceeding 3 clock-hours in size was confirmed in the lower temporal quadrant of the left eye. Three months after the initial half-time PDT, a second half-time PDT was performed owing to recurrent retinal detachment. Two months after the second half-time PDT, the retinal detachment resolved, and BCVA improved to 0.4, 6 months after the second half-time PDT. Lessons: In cases where the bullous variant of CSC is complicated by extensive PED, clinicians should consider the potential development of a giant RPE tear as a treatment complication.

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Pathogenic Risk Factors and Associated Outcomes in the Bullous Variant of Central Serous Chorioretinopathy

Cited by 2 publications

References 26 publications

Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome

Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome

Giant retinal pigment epithelial tear following photodynamic therapy for the bullous variant of central serous chorioretinopathy: A case report

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