Pathogenic Nocardia amamiensis infection: A rare case report and literature review

Zhang, Jing; Zhu, Yingwei; Sun, Yuxia; Han, Xuewei; Mao, Yimin

doi:10.1016/j.heliyon.2023.e17183

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e17183

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Pathogenic Nocardia amamiensis infection: A rare case report and literature review

Jing Zhang,

Yingwei Zhu,

Yuxia Sun

et al.

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2024

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Cited by 3 publications

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“…2 Nocardia can infect various organs in the human body, with the lungs, skin, and cornea being the most common sites. 3 To date, more than 100 Nocardia species have been identified through 16S rRNA gene sequencing analysis, and 9 common species or complexes are closely associated with human diseases. 4 As the cornea is exposed to environmental stress, Nocardia keratitis often arises after corneal trauma or surgery.…”

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Whole Genome Sequencing Highlights the Pathogenic Profile in Nocardia Keratitis

Guo,

Zhang,

Chen

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.Nocardia keratitis is a serious and sight-threatening condition. This study aims to reveal the virulence and antimicrobial resistance gene profile of Nocardia strains using whole genome sequencing. METHODS.Whole-genome sequencing was performed on 23 cornea-derived Nocardia strains. Together with genomic data from the respiratory tract and the environment, 141 genomes were then utilized for phylogenetic and pan-genome analyses, followed by virulence and antibiotic resistance analysis. The correlations between virulence genes and pathogenicity were experimentally validated, including the characteristics of Nocardia colonies and clinical and histopathological evaluations of Nocardia keratitis mice models. RESULTS.Whole-genome sequencing of 141 Nocardia strains revealed a mean of 220 virulence genes contributed to bacterial pathogenesis. The mce gene family analysis led to the categorization of strains from the cornea into groups A, B, and C. The colonies of group C had the largest diameter, height, and fastest growth rate. The size of corneal ulcers and the clinical scores showed a significant increase in mouse models induced by group C. The relative expression levels of pro-inflammatory cytokines (CD4, IFN-γ , IL-6Rα, and TNF-α) in the lesion area exhibited an increasing trend from group A to group C. Antibiotic resistance genes (ARGs) spanned nine distinct drug classes, four resistance mechanisms, and seven primary antimicrobial resistance gene families. CONCLUSIONS.Whole genome sequencing highlights the pathogenic role of mce gene family in Nocardia keratitis. Its distribution pattern may contribute to the distinct characteristics of the growth of Nocardia colonies and the clinical severity of the mice models.

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Whole Genome Sequencing Highlights the Pathogenic Profile in Nocardia Keratitis

Guo,

Zhang,

Chen

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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Exploring Nocardia’s ecological spectrum and novel therapeutic frontiers through whole-genome sequencing: unraveling drug resistance and virulence factors

Nathar,

Rajmichael,

Jeyaraj Pandian

et al. 2024

Arch Microbiol

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ECMO Treatment for the Infection of Nocardia Otitidis in Patients with Severe Pneumonia: A Case Report and Literature Review

王

2024

ACM

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Pathogenic Nocardia amamiensis infection: A rare case report and literature review

Cited by 3 publications

References 31 publications

Whole Genome Sequencing Highlights the Pathogenic Profile in Nocardia Keratitis

Whole Genome Sequencing Highlights the Pathogenic Profile in Nocardia Keratitis

Exploring Nocardia’s ecological spectrum and novel therapeutic frontiers through whole-genome sequencing: unraveling drug resistance and virulence factors

ECMO Treatment for the Infection of Nocardia Otitidis in Patients with Severe Pneumonia: A Case Report and Literature Review

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