Pathogenic Mechanism of
            <i>Vibrio Vulnificus</i>
            Infection

Lu, Kun Ping; Yang, Li V.; Chen, Rui; Yang, Hua; Wang, Yong; Xiong, Wei; Xu, Fen; Yuan, Qijun; Liang, Haihui; Xiao, Xian; Huang, Ren‐qiang; Chen, Zhipeng; Chen, Tian; Wang, Songqing

doi:10.2217/fmb-2022-0243

Cited by 5 publications

(2 citation statements)

References 78 publications

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“…Since BDTP showed excellent inhibition against E. coli and S. aureus, and because of the high pathogenicity and high mortality of V. vulnificus, as well as its extensive of drug resistance [24] , the antibacterial activity of BDTP against V. vulnificus was investigated. The relative amount of CFUs of V. vulnificus was measured.…”

Section: Antibacterial Activity Of Bdtp Against Free Bacteriamentioning

confidence: 99%

ROS Mediated the Photodynamic Antibacterial ofVibrio vulnificusby a DNA-Targeted Molecular Rotor Probe

Yue,

Bian,

et al. 2024

Preprint

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Vibrio vulnificus, a highly pathogenic Gram-negative bacterium, is capable of inducing sepsis, necrotizing fasciitis, and skin and soft tissue infections through contact with wounds. Currently, the majority ofV. vulnificusstrains have developed resistance to multiple drugs, highlighting the critical necessity for the development of novel therapeutics capable of effectively targeting and eradicating this bacterium. In recent years, material molecules have emerged as promising antimicrobial agents. This study introduces a novel molecular fluorescent probe, BDTP, which demonstrates a wide-ranging antimicrobial effect against both Gram-negative and Gram-positive bacteria while exhibiting minimal toxicity to normal mammalian cells. Of particular significance is BDTP’s ability to rapidly detect V. vulnificus, bind to bacterial DNA, and exhibit fluorescence monitoring behavior. Furthermore, BDTP displays enhanced photodynamic antibacterial activity when exposed to white light irradiation. Under a low dose of white light (15mW cm-2), the killing efficiency ofV. vulnificusirradiated with 4uM for 10 minutes was more than 99.8%. Moreover, it could significantly inhibit and eliminate the biofilm formed byV. vulnificus. It can induce the production of reactive oxygen species (ROS) inV. vulnificuscells, leading to bacterial cell damage. More importantly, BDTP significantly promoted the healing of infected wounds in an animal model ofV. vulnificusinfection. Therefore, BDTP shows great promise as a potent antibacterial agent againstV. vulnificusinfection.

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Section: Antibacterial Activity Of Bdtp Against Free Bacteriamentioning

confidence: 99%

ROS Mediated the Photodynamic Antibacterial ofVibrio vulnificusby a DNA-Targeted Molecular Rotor Probe

Yue,

Bian,

et al. 2024

Preprint

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“…Vibrio vulnificus , a Gram-negative bacterium, inhabits brackish waters in warm coastal regions. Infections typically arise from consuming raw or undercooked seafood or through exposure of open wounds to contaminated seawater or seafood ( 1 , 2 ). Vibrio vulnificus is a highly pathogenic bacterium associated with a mortality rate of up to 33% ( 1 ).…”

Section: Introductionmentioning

confidence: 99%

Vibrio vulnificus infection from insect bites in Shanghai: a case report

Hu,

Que

2024

Front. Med.

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BackgroundInfection with Vibrio vulnificus is associated with high rates of amputation and mortality. Alterations in the global climate have heightened the risk of atypical infections caused by this pathogen.Case presentationIn the case report we describe, a 75-year-old man residing in a coastal city contracted Vibrio vulnificus secondary to an insect bite.Discussion and conclusionThis case underscores the importance for clinicians of recognizing that early administration of appropriate antibiotics in patients with non-traditional routes of Vibrio vulnificus infection can significantly reduce rates of amputation and mortality.

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Current research on bacterial diseases in eel: An immunological perspective

Qi,

Wei,

et al. 2025

Aquaculture

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Pathogenic Mechanism of Vibrio Vulnificus Infection

Cited by 5 publications

References 78 publications

ROS Mediated the Photodynamic Antibacterial ofVibrio vulnificusby a DNA-Targeted Molecular Rotor Probe

ROS Mediated the Photodynamic Antibacterial ofVibrio vulnificusby a DNA-Targeted Molecular Rotor Probe

Vibrio vulnificus infection from insect bites in Shanghai: a case report

Current research on bacterial diseases in eel: An immunological perspective

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