Pathogenetic mechanisms of asbestos and other mineral fibres

Brown, R. C.; Hoskins, John A.; Miller, K.; Mossman, Brooke T.

doi:10.1016/0098-2997(90)90002-j

Cited by 24 publications

(4 citation statements)

References 65 publications

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“…Chrysotile is the most common type of asbestos used historically in over 2000 industrial products and found in US buildings and schools [Health Effects Institute‐Asbestos Research, 1991]. Although the association between amphibole asbestos exposure and the development of MM is well documented [Brown et al, 1990], the carcinogenic potential of chrysotile asbestos alone or with negligible amphibole contamination remains controversial [Steenland and Stayner, 1997; Yano et al, 2001; Robinson and Lake, 2005]. Some researches suggested that chrysotile asbestos may produce MMs in man, but the number of cases is small and the required exposures large [Churg, 1988].…”

Section: Factors Causing Malignant Mesotheliomamentioning

confidence: 99%

Cellular and molecular parameters of mesothelioma

Ramos-Niño

Testa

Altomare

et al. 2006

J of Cellular Biochemistry

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Malignant mesotheliomas (MM) are neoplasms arising from mesothelial cells that line the body cavities, most commonly the pleural and peritoneal cavities. Although traditionally recognized as associated with occupational asbestos exposures, MMs can appear in individuals with no documented exposures to asbestos fibers, and emerging data suggest that genetic susceptibility and simian virus 40 (SV40) infections also facilitate the development of MMs. Both asbestos exposure and transfection of human mesothelial cells with SV40 large and small antigens (Tag, tag) cause genetic modifications and cell signaling events, most notably the induction of cell survival pathways and activation of receptors, and other proteins that favor the growth and establishment of MMs as well as their resistance to chemotherapy. Recent advances in high-throughput technologies documenting gene and protein expression in patients and animal models of MMs can now be validated in human MM tissue arrays. These have revealed expression profiles that allow more accurate diagnosis and prognosis of MMs. More importantly, serum proteomics has revealed two new candidates (osteopontin and serum mesothelin-related protein or SMRP) potentially useful in screening individuals for MMs. These mechanistic approaches offer new hope for early detection and treatment of these devastating tumors. Keywords asbestos; mesothelioma; cancer; SV40Mesothelial cells are unusual in that they possess features of both mesenchymal and epithelial cells, and normally facilitate lubrication and movement of serosal surfaces [Mutsaers, 2004]. The processes involved in the initiation and development of malignant mesothelioma (MM), an aggressive tumor derived from mesothelial cells, are under intense investigation. The interest in this peculiar, phenotypically diverse cancer arises from the fact that its incidence is increasing worldwide, and patients generally die less than a year from initial diagnosis [Mossman and Gee, 1989;. Thus, MM represents a great challenge to clinicians and cancer researchers due to its poor prognosis and marked resistance to current therapies. MM is presently a worldwide problem [Bocchetta et al., 2001]. Although MM is a rare disease with an annual incidence in the USA of 2,000 to 3,000 cases, a steady rise in cases has been reported [Grondin and Sugarbaker, 1999] that may have recently plateaued [Weill et al., 2004]. In Europe, the incidence of MM has risen for decades and is expected to peak between the years 2010 and 2020 [Boutin et al., 1998]. Understanding the mechanisms of MM development and invasiveness, and elucidating potential biomarkers are intrinsic to prevention, screening, and effective therapies for MM. Here, we present recent data on the etiology and molecular pathogenesis of this tumor. FACTORS CAUSING MALIGNANT MESOTHELIOMAIn the US the most important causal factor for the development of human mesothelioma is occupational exposure to asbestos, primarily the amphiboles, crocidolite, and amosite [Mossman and Gee, 1989;Mossman et a...

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Section: Factors Causing Malignant Mesotheliomamentioning

confidence: 99%

Cellular and molecular parameters of mesothelioma

Ramos-Niño

Testa

Altomare

et al. 2006

J of Cellular Biochemistry

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“…The analysis is made by sample desorption in the oven, GC separation of the de pounds using N2 to flush the compounds onto the GC column in the gas flow cell, and identification at tion of NO, using the diode array spectrophotometer to register the specific UV spectrum of this compi larger specific surface area than crocidolite, amosite, and silicon carbide whiskers. As illustrated in Table 1 ionizable silanol groups on the surface (19). It appears that NO adsorbs more firmly to the magnesium hydroxide of chrysotile than to the silanol groups on the surface of amphiboles.…”

Section: Resultsmentioning

confidence: 93%

Demonstration of Nitric Oxide on Asbestos and Silicon Carbide Fibers with a New Ultraviolet Spectrophotometric Assay

Leanderson¹,

Lagesson²,

Tagesson³

1997

Environmental Health Perspectives

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Nitric oxide (NO) has a number of important functions in biological systems and may play a role in the toxicity of mineral fibers. We investigated whether NO might be present on the surface of mineral fibers and if crocidolite could adsorb NO from NO gas or cigarette smoke. NO was determined with a new gas chromatography-ultraviolet spectrophotometric technique after thermal desorption from the fiber surface and injection in a gas flow cell. NO was found in different amounts on chrysotile B, crocidolite, amosite, and silicon carbide whiskers. There was a strong correlation between the amount of NO and the specific surface area of these fibers (r=0.98). NO could not be demonstrated on rockwool fibers [man-made vitreous fiber(s) (MMVF)21 and MMVF22I or silicon nitride whiskers. NO on crocidolite, amosite, and silicon carbide whiskers was readily desorbed from the fibers at increased temperature, while NO on chrysotile B seemed to be more firmly adsorbed to the fiber and required a longer period of time to be desorbed. The amount of NO bound to crocidolite increased from 34 pg/g fiber to 85 and 474 pg/g after exposing the fibers to cigarette smoke and NO gas, respectively. These findings indicate that a) NO adsorbs to fiber surfaces, b) some fibers adsorb more NO than others, c) some fibers adsorb NO more strongly than others, and d) the amounts of NO on fibers may be increased after exposure of the fiber to cigarette smoke or other sources of NO. The biological significance of NO on mineral fibers remains to be investigated.

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“…These air pollutants cause to acute illness such as vomiting, chronic diseases such as cancer, as well as immunologic, neurologic, reproductive, developmental and respiratory diseases. Exposure of these chemicals increases the risk of pleural and peritoneal tumors and lung cancer incidence [47][48][49][50].…”

Section: Air Pollutionmentioning

confidence: 99%

Which Environment Makes Cancer?

Kaleli¹,

Deveci²,

Eskiler³

2018

Oncol Res Rev

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Cancer occurs with uncontrolled cell growth or abnormal cell division in DNA damage. Carcinogens are the factors that cause DNA mutations and they are known to cause cancer in our body by making changes in gene level. Genetic susceptibility is also important in cancer development along with factors such as poor living conditions. Additionally, all these environmental factors such as X-rays, gamma rays, the radiation emitted from radioactive materials, aniline type dyes, cigarette, free radicals, asbestos, silica dust, air pollution, food additives, various drugs, some of the chemicals used in perfumes, oncogenic viruses and bacteria are playing an important role in cancer formation and contribute the increase of incidence of cancer. The environmental factors that cause cancer are located in air, water, soil and the food that we need to live. Consequently, human get cancer from exposure to carcinogens from the environment where they live. The cancer is a difficult disease to treat and reduces the life quality of people with cancer. Investigation of the effects of environmental factors in cancer and prevention of the cancer development by determining the factors that cause cancer are very important from this perspective.

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Pathogenetic mechanisms of asbestos and other mineral fibres

Cited by 24 publications

References 65 publications

Cellular and molecular parameters of mesothelioma

Cellular and molecular parameters of mesothelioma

Demonstration of Nitric Oxide on Asbestos and Silicon Carbide Fibers with a New Ultraviolet Spectrophotometric Assay

Which Environment Makes Cancer?

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