Pathogenetic Aspects of Anemia in Long-Term Hemodialyzed Patients

Buscarini, L

doi:10.1159/000208025

Cited by 2 publications

(2 citation statements)

References 12 publications

(15 reference statements)

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“…Similar observations have been reported by Jezuita (1976), who showed that erythrocyte glycolysis is stimulated in haemolytic syndromes with an increase in P" y and also, ADP and ATP, but to a lesser extent in DPG. The shortening of erythrocyte life span has been demonstrated in patients on maintenance dialysis, due mainly to extracorporeal circulation (Buscarini, 1976). The increased carboxyhaemoglobin in our patients may also reflect enhanced haemolysis (Necheles, Rai & Valaes, 1976).…”

Section: Discussionsupporting

confidence: 56%

Oxygen Transport in Children on Maintenance Haemodialysis

et al. 1978

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1. Adaptive mechanisms of oxygen transport by blood have been studied in severely anaemic young patients on maintenance haemodialysis, in conditions of hyperphosphataemia (Pi greater than or equal to 2.2 mmol/l) or normophosphataemia. 2. In hyperphosphataemia whole-blood affinity for oxygen was slightly decreased, as measured by an increase in P50 (the partial pressure of oxygen necessary to half saturate haemoglobin). 2,3-Diphosphoglycerate was increased by 10% (P less than 0.10) whereas Pi, total erythrocyte phosphate and ATP were increased by 100%, 47% and 36% respectively, compared with control values. 3. After correction of hyperphosphataemia a small but significant decrease in P50 and 2,3-diphosphoglycerate, to normal values, was observed whereas the other variables, although significantly lowered, remained above control values. 4. In these severely anaemic and hyperphosphataemic patients P50 and 2,3-diphosphoglycerate are only slightly increased. ATP synthesis appears to be favoured over that of 2,3-diphosphoglycerate. This is possibly due to alterations in the erythrocyte membrane elicited by bi-weekly extracorporeal circulation. Adequate oxygen transport can be achieved only through a drastic increase in blood flow. Correction of hyperphosphataemia adds further to the abnormality. It is concluded that this condition could induce a long-term myocardial fatigue, which might be prevented with occasional small blood transfusions.

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Section: Discussionsupporting

confidence: 56%

Oxygen Transport in Children on Maintenance Haemodialysis

et al. 1978

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“…A close correlation between glomerulus filtrate and hemoglobin concentration has been noted; in children, r = 0.73 [29]. The two pathoge netic components discussed in renal anemia are an aplastic disorder of the bone marrow, related with an erythropoietine deficiency, and a shortened erythrocyte survival of hitherto unknown reason [1,4,6, 8, 15,[18][19][20][21][22][23][24][38][39][40],In patients with terminal renal insuffi ciency, erythrocyte survival was reduced to 30-60% of the normal value [12, 13]. The hemolytic aspect of anemia in uremia is thought to be caused by alterations in the structure and function of the erythrocytes induced by elevated concentrations of toxic substances in the plasma [21-23, 27, 35, 38-40], The hemolysis-promoting effect of…”

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confidence: 99%

Erythrocyte and Plasma Lipids in Terminal Renal Insufficiency

Bleiber¹,

Eggert²,

Reichmann³

et al. 1980

Acta Haematol

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Lipids in erythrocytes and plasma of children and adults with terminal renal insufficiency were determined and compared with those of normal controls. The erythrocyte phospholipids in uremic patients were altered in phosphatidylethanolamine (absolutely and relatively elevated) and in lecithin (relatively diminished). Sphingomyelin, phosphatidylserine, total erythrocyte phospholipid content and cholesterol were within the normal range. The detailed analysis of the distribution of plasma phospholipids showed an increase in all phospholipids except phosphatidylserine. The unesterified plasma cholesterol was also found to be elevated. The fatty acid distribution in the individual erythrocyte phospholipids showed the following variations in comparison with controls: one main fatty acid was significantly decreased in sphingomyelin and in lecithin and slightly decreased in phosphatidylethanolamine. It could be shown that the lipid alterations in uremic erythrocytes were quite different from those in plasma. There were no typical signs for an increased lipid peroxidation in the erythrocytes of patients with renal insufficiency.

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Pathogenetic Aspects of Anemia in Long-Term Hemodialyzed Patients

Cited by 2 publications

References 12 publications

Oxygen Transport in Children on Maintenance Haemodialysis

Oxygen Transport in Children on Maintenance Haemodialysis

Erythrocyte and Plasma Lipids in Terminal Renal Insufficiency

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