Pathogenesis, Transmissibility, and Tropism of a Highly Pathogenic Avian Influenza A(H7N7) Virus Associated With Human Conjunctivitis in Italy, 2013

Belser, Jessica A.; Creager, Hannah M.; Zeng, Hui; Maines, Taronna R.; Tumpey, Terrence M.

doi:10.1093/infdis/jiw559

Cited by 8 publications

(4 citation statements)

References 18 publications

(33 reference statements)

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“…This observation is consistent with reports of other North American lineage viruses [8,15,21]. Infection with this virus also manifests as a mild respiratory illness in animal models [22].…”

Section: Discussionsupporting

confidence: 92%

Detection of Avian Influenza A(H7N2) Virus Infection Among Animal Shelter Workers Using a Novel Serological Approach—New York City, 2016–2017

Poirot

Levine

Russell

et al. 2018

The Journal of Infectious Diseases

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Background.-In 2016, an influenza A(H7N2) virus outbreak occurred in cats in New York City's municipal animal shelters. One human infection was initially detected.Methods.-We conducted a serological survey using a novel approach to rule out cross-reactive antibodies to other seasonal influenza viruses to determine whether additional A(H7N2) human infections had occurred and to assess exposure risk.Results.-Of 121 shelter workers, one had serological evidence of A(H7N2) infection, corresponding to a seroprevalence of 0.8% (95% confidence interval, .02%-4.5%). Five persons exhibited low positive titers to A(H7N2) virus, indicating possible infection; however, we could not exclude cross-reactive antibody responses to seasonal influenza viruses. The remaining 115 persons were seronegative. The seropositive person reported multiple direct cat exposures without using personal protective equipment and mild illness with subjective fever, runny nose, and sore throat.

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Section: Discussionsupporting

confidence: 92%

Detection of Avian Influenza A(H7N2) Virus Infection Among Animal Shelter Workers Using a Novel Serological Approach—New York City, 2016–2017

Poirot

Levine

Russell

et al. 2018

The Journal of Infectious Diseases

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“…Moreover, an avian H7N7 isolated from an individual with respiratory disease was transmitted to naïve control ferrets only by direct contact. 92,93 Infection of eye conjunctiva by the avian H7N7 virus correlates with the predominance of SAα2,3. 91,95,96 Recently, two human cases of associated conjunctivitis were reported in two Mexican workers during an outbreak of highly pathogenic avian H7N3 in poultry flocks.…”

mentioning

confidence: 99%

Sialic acid receptors: focus on their role in influenza infection

Ayora-Talavera¹

2018

JRLCR

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“…H7 avian influenza viruses represent a major public health concern, as these antigenically divergent viruses cause yearly outbreaks in poultry worldwide. Most human infections with avian influenza H7 viruses occurred after exposure to poultry, without evidence of sustained human transmission [1][2][3][4][5][6][7][8] . During previous occurrences of H7 influenza virus outbreaks among poultry, the numbers of human cases were limited and disease was mild, but severe human disease with a case fatality rate of up to 40% has been observed during the recent outbreaks of avian H7N9 in China (WHO) 9,10 .…”

mentioning

confidence: 99%

Specific memory B cell response in humans upon infection with highly pathogenic H7N7 avian influenza virus

Westerhuis

Hulscher

Jacobi

et al. 2020

Sci Rep

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H7 avian influenza viruses represent a major public health concern, and worldwide outbreaks raise the risk of a potential pandemic. Understanding the memory B cell response to avian (H7) influenza virus infection in humans could provide insights in the potential key to human infection risks. We investigated an epizootic of the highly pathogenic A(H7N7) in the Netherlands, which in 2003 led to infection of 89 persons and one fatal case. Subtype-specificity of antibodies were determined for confirmed H7N7 infected individuals (cases) (n = 19), contacts of these cases (n = 21) and a comparison group controls (n = 16), by microarray, using recombinant hemagglutinin (HA)1 proteins. The frequency and specificity of memory B cells was determined by detecting subtype-specific antibodies in the culture supernatants from in vitro stimulated oligoclonal B cell cultures, from peripheral blood of cases and controls. All cases (100%) had high antibody titers specific for A(H7N7)2003 (GMT > 100), whereas H7-HA1 antigen binding was detected in 29% of contacts and 31% of controls, suggesting that some of the H7 reactivity stems from cross reactive antibodies. To unravel homotypic and heterotypic responses, the frequency and specificity of memory B cells were determined in 2 cases. Ten of 123 HA1 reactive clones isolated from the cases bound to only H7-HA1, whereas 5 bound both H7 and other HA1 antigens. We recovered at least four different epitopal reactivities, though none of the H7 reactive antibodies were able to neutralize H7 infections in vitro. Our study serologically confirms the infection with H7 avian influenza viruses, and shows that H7 infection triggers a mixture of strain-specific and cross-reactive antibodies.

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Pathogenesis, Transmissibility, and Tropism of a Highly Pathogenic Avian Influenza A(H7N7) Virus Associated With Human Conjunctivitis in Italy, 2013

Cited by 8 publications

References 18 publications

Detection of Avian Influenza A(H7N2) Virus Infection Among Animal Shelter Workers Using a Novel Serological Approach—New York City, 2016–2017

Detection of Avian Influenza A(H7N2) Virus Infection Among Animal Shelter Workers Using a Novel Serological Approach—New York City, 2016–2017

Sialic acid receptors: focus on their role in influenza infection

Specific memory B cell response in humans upon infection with highly pathogenic H7N7 avian influenza virus

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