Pathogenesis of Trypanosoma (brucei) evansi in small East African goats

Ngeranwa, J.J.N.; Gathumbi, P. K.; Mutiga, E.R.; Agumbah, G J O

doi:10.1016/0034-5288(93)90124-x

Cited by 47 publications

(32 citation statements)

References 9 publications

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“…The main histopathological changes in the kidneys which included acute congestion of the glomerular tuft agreed with the result reported by Bal et al [3] and Sivajothi et al [51] in the rats infected with T. evansi and similar, also, with the result reported by Onah et al [54] and Auduo et al [55]. It has been reported that changes in the kidneys are mainly due to the toxins produced by the parasite and the accumulation of immune complexes which impair the structure and function of the kidney [56][57]. The lack of significant histopathological alterations observed in the liver in this study was similar to the result reported by Adewale et al [58]; but, however, it was not similar to the result reported by Reham and Magdi [48]; Bal et al [3]; Sivajothi et al [51]; Onah et al [54] and Audue et al [55].…”

Section: Discussionsupporting

confidence: 82%

Serum Biochemical and Histopathological Changes in Rats Experimentally Infected with Trypanosoma evansi Isolated from Dromedary Camels in Sudan

Abuessailla¹,

Aa²,

Agab³

et al. 2017

IJLSSR

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ABSTRACT-The biochemical and histopathological changes in rats experimentally infected with T. evansi isolated from camels in El-Gadarif State, Sudan, were studied. A number of 18 adult male outbred albino rats, weighing between 133-137g were used in the study. The rats were divided into 3 groups of 6 animals each (A,B and E). Group A and B were intraperitoneally infected with T. evansi (Showak stabilate) with 1×10 4 trypanosoma for the inoculum. Group B was given quinapyramine sulphate (20 mg/kg bwt) after parasitaemia was evident. Group E was left healthy uninfected controls for the stabilate. There was significant reduction in serum glucose and phosphorus; compared to significant increase in Glutamate Oxaloacetate Transaminase (GOT), Glutamate Pyruvate Transaminase (GPT) and total protein in groups (A and B). Microscopically, the brain tissues of the infected rats revealed acute congestion of the meningeal capillaries, perivascular oedema, neuronecrosis (vaculation), gliosis and trypomastigotes in dilated capillaries. The lung revealed oedema, congestion, multifocal alveolar emphysema, hyperplasia of the peri-bronchiolar lymphoid tissues and haemorrhages. The spleen showed extensive haemorrhages, haemosiderosis and aggregation of histiocytes resulting in multinuclear giant cells formation. The kidneys showed acute congestion of the glomerular tufts. All tissues obtained showed exactly the same histopathological changes. No significant histopathological alterations were observed in the liver and heart. The most consistent histopathological changes were seen in the brain, lungs, spleen and kidneys. These changes were consistent with trypanosome infection and were confirmed by the presence of trypanosomes in most of the tissue sections examined.

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Section: Discussionsupporting

confidence: 82%

Serum Biochemical and Histopathological Changes in Rats Experimentally Infected with Trypanosoma evansi Isolated from Dromedary Camels in Sudan

Abuessailla¹,

Aa²,

Agab³

et al. 2017

IJLSSR

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“…6). It has been reported that changes in kidneys are mainly due to toxins produced the parasite and accumulation of immune complexes which impair the structure and function of the kidney (Morrison et al 1981;Ngeranwa et al 1993). …”

Section: Kidneysmentioning

confidence: 99%

Pathological studies on experimental Trypanosoma evansi infection in Swiss albino mice

et al. 2012

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The pathology of Trypanosoma evansi infection was studied in Swiss albino mice using cattle isolate of the parasite. Sixteen Swiss albino mice were used in the experiment and were divided into two groups viz. infected group (I) and uninfected healthy control group (II) comprising 12 and four mice, respectively. Twelve mice from group I were infected with 1 9 10 5 purified trypanosomes. Systematic necropsy examination specifically of the infected mice (group I) as well as of healthy control (group II) was performed and pathological changes were recorded. The different tissue samples were collected in 10 % neutral buffered formal saline and were used to study the histopathological changes. Gross post-mortem examination revealed enlargement of spleen, petechial haemorrhages in liver in the terminal stages of disease. Tissue sections revealed presence of numerous trypanosomes in blood vessels of liver, spleen, brain and kidneys. Microscopically, liver revealed lesions varying from vacuolar degeneration, coagulative necrosis along with congestion and haemorrhages. Spleen showed extensive haemorrhages in red pulp area, haemosiderosis and aggregation of histiocytes resulting in multinuclear giant cell formation. Lungs revealed oedema, congestion and mild inflammatory changes. Brain revealed mild degenerative changes along with congestion of meningeal blood vessels. Kidneys showed tubular degeneration, congestion and cellular infiltration. Heart revealed mild degenerative changes along with interstitial oedema. All changes were consistent with trypanosome infection and were confirmed by presence of trypanosomes in most of the tissue sections examined.

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“…The most important disease to affect the camel is the blood parasite, Trypanosoma evansi (Ngeranwa et al 1993). The blood parasites are removed and phagocytosed in the spleen (Schnizer et al 1972 ;Chen & Weiss, 1973).…”

Section: mentioning

confidence: 99%

The spleen of the one humped camel (Camelus dromedarius) has a unique histological structure

et al. 2000

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The histology and structure of 38 spleens of the dromedary (aged 0n5-15 y) were studied in relation to age. The spleen was found to have a thick capsule (292p106 mm) divided into an outer layer (113p39 mm) composed mainly of connective tissue and an inner layer (180p81 mm) consisting mainly of smooth muscle cells. Vascular and avascular trabeculae extend from the capsule, the former containing arteries and nerves but no trabecular veins, the latter being divided structurally into primary and secondary trabeculae. Subcapsular and peritrabecular blood sinuses around primary and vascular trabeculae are unique to the camel spleen. The central artery emerges from the periarterial lymphatic sheath and branches into up to 4 penicilli which extend as sheathed arterioles (42p8 µm). These are found near or surrounded by blood sinusoids of the red pulp. A wide marginal zone surrounds the white pulp and contains sheathed arteries but no marginal sinuses. The red pulp is characteristically divided into cords by secondary trabeculae and contains venous sinusoids of different sizes. The camel spleen is of a sinusal type that can store blood. The thick muscular capsule and trabeculae pump the stored blood according to the body's need. Both closed and open circulations are found. The venous return is unique as the blood flow is from the venous sinusoids of the red pulp to the peritrabecular sinuses to the subcapsular sinuses to the splenic vein. No significant structural differences related to age were found.

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Pathogenesis of Trypanosoma (brucei) evansi in small East African goats

Cited by 47 publications

References 9 publications

Serum Biochemical and Histopathological Changes in Rats Experimentally Infected with Trypanosoma evansi Isolated from Dromedary Camels in Sudan

Serum Biochemical and Histopathological Changes in Rats Experimentally Infected with Trypanosoma evansi Isolated from Dromedary Camels in Sudan

Pathological studies on experimental Trypanosoma evansi infection in Swiss albino mice

The spleen of the one humped camel (Camelus dromedarius) has a unique histological structure

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