Pathogenesis of Thrombosed Giant Aneurysm

A rare case report of spontaneous thrombosis in unruptured giant intracranial aneurysm

“…Spontaneous clinical improvement of a ruptured aneurysm was suggested if 3 conditions were present, namely the disappearance of the aneurysm with patency of parent artery and without spasm, good clinical neurologic outcome, and absence of cerebral infarction on brain imaging [14] . These improvements can be observed during a follow-up intracranial angiography, performed at least 3 months after subarachnoid hemorrhage [13] . Although the 3 conditions were met in this present case except for the subarachnoid hemorrhage condition, intensive observation was still needed [15] .…”

“…Although spontaneous thrombosis can occur in patients with GIA, it does not necessarily guarantee complete clinical improvement, as the thrombosed aneurysm can still progress in various ways, including growth, stabilization, rupture, and recanalization [12] . This indicates that the terms “complete” or “spontaneous” cure must be used cautiously until the natural history of thrombotic aneurysm is clearly understood [13] . Spontaneous clinical improvement of a ruptured aneurysm was suggested if 3 conditions were present, namely the disappearance of the aneurysm with patency of parent artery and without spasm, good clinical neurologic outcome, and absence of cerebral infarction on brain imaging [14] .…”