Pathogenesis of Thromboembolism and Endovascular Management

Behravesh, Sasan; Hoang, P.; Nanda, Alisha; Wallace, Alex; Sheth, Rahul A.; Deipolyi, Amy R.; Memić, Adnan; Naidu, Sailendra; Öklü, Rahmi

doi:10.1155/2017/3039713

Cited by 34 publications

(37 citation statements)

References 83 publications

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“…In a mouse models of ARDS, infection with the influenza virus increases platelet aggregation, pulmonary microvascular thrombosis, endothelial damage and the hyper-inflammatory cytokine responses [26,27,28]. Dysregulation of these same physiologic responses have been associated with pulmonary embolism (PE) [29], and prior studies have described PE in the setting of influenza infection [2,3].…”

Section: Discussionmentioning

confidence: 99%

Clinical and Imaging Findings in COVID-19 Patients Complicated by Pulmonary Embolism

2020

Preprint

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All the authors have no conflicts of interest to disclose. AcknowledgementWe thank Sudhakar, Pipavath in University of Washington for his valuable contribution in editing the manuscript. AbstractObjective: To describe clinical, and imaging findings including the evolution pattern in COVID-19 pneumonia complicated by pulmonary embolism (PE). Methods:Eleven of 1453 patients with a probable diagnosis of COVID-19 pneumonia were retrospectively selected for the presence of PE. Clinical and laboratory data were recorded. All cross-sectional CT imaging was qualitatively scored for the first 28 days after onset of symptoms. Results:Of 24 patients underwent CTA-PE, 11 were confirmed with PE. All 11 patients developed acute respiratory distress syndrome (ARDS). The pulmonary emboli were most common in segmental and subsegmental pulmonary arteries. We observed an evolution pattern of predominant findings with ground-glass opacities (GGO) to GGO with crazy paving in 3 patients, then to consolidation with linear densities, or to reticulation in 9 patients. Lung cysts or traction bronchiectasis could be seen from day 5 to 9 after symptoms and reticulation, subpleural curvilinear lines were more common from day 20. The pulmonary opacities were predominantly peripheral in distribution with relative sparing of nondependent lungs. The severity of . CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) : medRxiv preprint lung involvement was high with an average score of 9.7 in the first phase, 18 in the second phase plateauing in the next two phases, with a slight decrease to 16.9 in the late phase. Conclusion:The incidence of PE among suspected patients in COVID-19 was high. The pulmonary emboli were most common in segmental and subsegmental pulmonary arteries. Our study suggests PE may occur with increased frequency in the ARDS subgroup. The evolution of radiographic abnormalities showed a general pattern, but are also unique with more extensive lung injury and specific imaging features, which may due to the exist of ARDS in these patients.

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Section: Discussionmentioning

confidence: 99%

Clinical and Imaging Findings in COVID-19 Patients Complicated by Pulmonary Embolism

2020

Preprint

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“…[49][50][51][52] Additionally, studies have demonstrated that QI initiatives paired with improved communication between care team members and education emphasizing the importance of VTE prophylaxis can lead to higher rates of appropriate prophylaxis. [53][54][55] Our own institution's use of the DMAIC framework led us to implement many of the previously supported counter- Through the recognition of these patient variables the system can further eliminate VTE prophylaxis that is contraindicated or simply not indicated, that is, enoxaparin in the context of decreased renal function or low dose (5000 unit) heparin for patients with BMI > 40 kg/m 2 .…”

Section: Eras and Vte-prophylaxismentioning

confidence: 99%

ERAS: Safety checklists, antibiotics, and VTE prophylaxis

Moffatt-Bruce

Hilligoss

Gonsenhauser

2017

Journal of Surgical Oncology

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The concept rested on several components that many of us have now tried to adopt or improve on, inclusive of a multidisciplinary team, a multimodal approach to anesthesia and preoperative preparedness, evidence-based approach to care protocols; and a change in management using interactive and continuous audit prior to and post-procedure. This article describes the development of ERAS protocols relative to checklist implementation, antibiotic use, and venous thromboembolism (VTE) prevention, how these ideas are developed and operationalized as well as how they are evolving and spreading across the care continuum to achieve sustained outcome improvements.

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“…In 2007 this pathology was found to be responsible for about 12% of deaths in Europe (Amaral, & Tavares, 2013) and direct healthcare costs related to VTE in the European Union per year range from 1.5 to 13.2 (Behravesh, Hoang, Nanda, Wallace, Sheth, Deipolyi, & Oklu, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…In the long term complications of VTE such as post-thrombotic syndrome and chronic pulmonary hypertension may arise (Behravesh, Hoang, Nanda, Wallace, Sheth, Deipolyi, & Oklu, 2017) which may increase hospital admission days and future hospital admissions. Given the importance of this issue, VTE prophylaxis is one of the most costeffective measures of clinical practice and is a priority strategy to improve the safety of hospitalized patients (Amaral & Tavares, 2013).…”

Section: Introductionmentioning

confidence: 99%

Preventive Measures Of Venous Thromboembolism In The Hospitalized Patient: An Integrative Literature Review

Albuquerque¹,

Costa²,

Martins³

et al. 2017

European Proceedings of Social and Behavioural Sciences

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Venous thromboembolism (VTE) includes two closely associated clinical conditions: deep vein thrombosis (DTV) and its main acute complication, pulmonary embolism (PE). In the hospital setting, venous thromboembolism is a concern because of its high prevalence rate. It is estimated that one in twenty inpatients is at risk of pulmonary embolism, if adequate preventive measures are not applied.These may or may not be pharmacological. In this context, the objective of this study is to identify the non-pharmacological measures recommended to prevent venous thromboembolism in inpatients. An integrative literature review was performed using the PI[C]OD method by searching the following databases: EBSCO host, PubMed, JBI, PEDro, Elsevier-ClinicalKey, Scielo and Google Academic studies published in the períod 2006-2016. From the research were included five articles that met the inclusion criteria. The results of the review found that effective mechanical methods comprised graduated compression stockings and intermittent pneumatic compression devices while for nursing care early mobilization and ambulation were identified as preventive measures of VTE. The studies suggest several benefits of using non-pharmacological measures to prevent venous thromboembolism. The differentiated intervention of the nurse specialist in rehabilitation integrated in the multidisciplinary team can be an added value in the adequacy of these measures.

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Pathogenesis of Thromboembolism and Endovascular Management

Cited by 34 publications

References 83 publications

Clinical and Imaging Findings in COVID-19 Patients Complicated by Pulmonary Embolism

Clinical and Imaging Findings in COVID-19 Patients Complicated by Pulmonary Embolism

ERAS: Safety checklists, antibiotics, and VTE prophylaxis

Preventive Measures Of Venous Thromboembolism In The Hospitalized Patient: An Integrative Literature Review

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